Objective To study the effect on using L‐carnitine in early intravenous nutrition of premature infants which aims to improve fat metabolism ,promote growth and development .Methods Ninety cases of premature infants were divided into the con‐trol group and observation group .All patients received conventional treatments such as keeping warm ,giving intravenous nutrition , etc .And those in the observation group received L‐carnitine beside routine care ,then compared efficacy of 2 groups .Results Total protein ,albumin ,hemoglobin ,body weight growth of the observation group are better than those of the control group(P<0 .05) . The observation group was superior to the control group in not only reducing incidence rate of preterm children PNAC but also in improving the treatment effect .Conclusion Using L‐carnitine in early intravenous nutrition of premature infants could improve fat metabolism ,promote growth effect ,reduce the incidence rate of cholestasis with few adverse effects .