Objective To study neuromechanism for uremic restless syndrome (URLS),functional MRI (fMRI) analysis and were used to explor main activity.Methods Resting state functional magnetic resonance imaging (MRI) was performed on 29 patients with uremic restless legs syndrome and 25 healthy controls.The values of the regional homogeneity (ReHo) of the two groups were calculated and analyzed statistically.Result As compared with the control group,patients with uremic restless legs syndrome showed emotional and mental abnormality.Increased ReHo values in bilateral supplementary motor area,bilateral thalamus,left insular lobe,left hippocampus (P＜0.05),and decreased ReHo values in anterior cingulate gyrus,bilateral posterior central gyrus,right amygdala were found in patients with uremic restless legs syndrome (P＜0.05).The severity score of RLS was respectively positively correlated with dialysis duration (r =0.57,P =0.002),PTH level (r =0.419,P =0.033)BAI (r =0.528,P=0.006),and BDI (r =0.567,P =0.003).Conclusion Neuronal activity in related brain area in patients with uremic restless legs syndrome were found.This abnormality provides an objective diagnostic basis for the explanation of restless legs syndrome in maintenance hemodialysis patients.

Objective: To explore the potential clinical risk factors related to abnormal microstructure of brain gray matter in end-stage renal disease (ESRD) patients with cognitive dysfunction. Methods: 3D high-resolution structural imaging was applied in 34 ESRD patients before hemodialysis and 34 health controls. We analyzed the characteristics of changes in gray matter cortical thickness in patients with ESRD before the first dialysis by surface based morphology (SBM) analysis. Further Pearson correlation analysis was used to reveal the relationship of the changed cortical thickness with the laboratory test indicators and clinical scale scores in patient group, with the covariants of age, sex and education removed. Results: Compared with that in control group, the broad cortex thickness decreases were observed in patients with ESRD before the first dialysis (P<0.01, FDR corrected), mainly including the bilateral postcentral gyrus, bilateral precentral gyrus, bilateral inferior parietal lobe (IPL), bilateral precuneus and some frontal and temporal lobes. Pearson correlation analysis showed that the cortical thickness in the IPL and precuneus had significantly negative correlation with uric acid level (r=-0.543, P<0.01) and the decreased thickness of bilateral IPL was positively related to AVL-IR score (right r=0.522, left r=0.649, P<0.01). Conclusion: ESRD patients showed extensive cortical thickness reduction before dialysis initiation, which corrected with overall cognition and immediate memory dysfunction. High uric acid level was the major factor of morphlolgical changes in ESRD patients before dialysis initiation.

Objective: To investigate the changes of insular functional connectivity in patients with uremic restless legs syndrome (uRLS) using seed-based resting-state functional connectivity analysis so as to explore the related risk factors for RLS. Methods: 3D high-resolution structural imaging was applied in 29 patients with uremic restless legs (uRLS group) and 29 healthy volunteers (control group) with maintenance hemodialysis. The greymatter volume of the insular cortex was assessed using a voxel-based morphometry (VBM) analysis and functional connectivity of insular variation was evaluated by a seed-based correlation analysis, while the seed was chosen as the significant difference of grey matter volume. Pearson correlation analysis was used to explore the significant correlation between functional connectivity and RLS score. The relationship between brain alterations and clinical variables were investigated with Logistic stepwise multiple regression analysis. Results: Compared with that in the control group, the area with reduced gray matter volume in the uRLS group was located on the left posterior insula (P<0.05, FWE correction). Taking the left post insular as a seed region, we further found reduced functional connectivity in patients mainly between the insular and primary sensorimotor cortex (S1), supplementary motor areas (SMA), and posterior mid-cingulate gyrus (P<0.05, FDR corrected). In uRLS group, the severity score of RLS was negatively correlated with insular-S1 functional connectivity (P<0.05, FDR corrected), while the hemoglobin level was negetively correlated with functional connectivity degree of insular-S1 (r=-0.449, P=0.015, FDR corrected). Conclusion: The altered morphology of the post insular cortex was revealed in uRLS patients. Abnormal sensorimotor activities in patients with RLS were closely associated with reduced functional connectivity of insular-S1. Low hemoglobin level was the most important risk factor for the abnormal functional connectivity of the brain.

Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Fracture Fixation, Intramedullary ; methods ; Fractures, Bone ; surgery ; Humans ; Humerus ; surgery ; Male ; Middle Aged ; Treatment Outcome ; Young Adult

Objective:To study the effect of microsurgery for parasellar menningiomas and to analyze the impact factors of recurrence. Methods:Clinical and follow-up data in a consecutive series of 134 patients with parasellar meningiomas were retrospectively analyzed. Results:A total of 109 patients (81.3%) had radical removal (Simpson grade I and II), and 116 patients were followed up for an average period of 81.6 months. The mean quality of life score (KPS) was 91.9, 90 patients regained full daily activity and 16 patients were able to take care of themselves. Oculomotor paralysis occurred in 7 patients, epilepsy in 8, and another 9 patients suffered hemispheral paralysis. Tumor recurred atfer the radical removal in 12 out of the 96 follow-up patients (12.5%). Tumor progressed atfer subtotal removal in 12 out of the 20 follow-up patients (60%). Tumor with cavernous sinus (CS) invasion had significantly higher risk of recurrence campared with non-CS invasion (P=0.043). The recurrence rate increased with the pathological grade (P<0.01). Conclusion:Patients with parasellar meningiomas undergoing microsurgical resection may have a good long-term function outcome. For most patients, total removal by microsurgery is the ifrst choice. Careful follow-up is needed if tumor invaded the CS and radiosurgery is proposed for WHO grade 1 and 2.

Objective To evaluate the effect of endoscopic management of foreign bodies in the upper digestive tract. Methods Clinical data and endoscopic treatment methods of 41 patients were retrospectively analyzed from October 2014 to May 2016. Patients with incomplete medical records were excluded. Results Foreign bodies in the upper digestive tract occurred high frequency in elderly. 53.6% of the foreign bodies were located in the esophagus. Date stones was the main type of foreign bodies (56.1%). 41 cases with foreign bodies in digestive tract were successfully extracted, while 1 case occurred perforation. Conclusion Endoscopic management of gastrointestinal foreign bodies is safe and effective.

This paper introduces a pathological information network and image analysis system designed by ourselves. The system offers an efficient means for modern medical diagnosis and treatment, teaching, research and management in the department of pathology.
Diagnostic Imaging ; Information Services ; Pathology, Clinical ; methods ; Radiology Information Systems ; Software Design ; Systems Analysis

For epidemiological investigation of the rabies virus carrier rates of domestic dogs, cats and wild animals like rodent animals and bats,three kinds of regions where rabies had higher incidence (Hunan and Guizhou Provinces), lower incidence (Jiangsu Province, Wuhan City) and provisionally rabies-free (Shenyang City) were selected. Then the antigenic types, the genovariation of the isolaled viruses and the currently vaccine matching of the virus strains were analyzed. The results showed that in China the principal host of rabies is dog,the total virus carrier rate of the captured dogs was 2.56%, and the highest positive isolation rate was 20.0% in some monitoring site. However,there was no evidence about the rabies virus carrier rate in rodent animals,bats or other wild animals. The rabies vaccines which prepared from aG and CTN strains have already been produced successfully in China. The research showed that the nucleotide sequences of the newly isolated viruses were more similar with the glycoprotein gene of CTN strain. In order to evaluate the safety and the efficacy of the vaccines currently used, two groups (50 people each) were injected with vaccine of aG strain and CTN strain respectively in five surveillance points. The neutralizing antibody tested were 0.49 IU/mL-0.52 IU/mL and 6.7 IU/mL-7.53 IU/mL after the 7 and the 14 days of vaccine injection respectively. In addition, the rates of antibody positive seroconversion were 45.1%-47.9% and 100% respectively, and there was no moderate or severe adverse reactions observed. These data showed the vaccines have satisfactory effect on safety and protection.
Animals ; Antibodies, Viral ; blood ; Carrier State ; epidemiology ; veterinary ; Cats ; virology ; Cercopithecus aethiops ; Dogs ; virology ; Enzyme-Linked Immunosorbent Assay ; Fluorescent Antibody Technique ; Rabies Vaccines ; immunology ; Rabies virus ; classification ; genetics ; isolation & purification ; Vero Cells

Objective:To evaluate the intervention effects of aquatic therapeutic exercise on functioning and quality of life for children and youth with cerebral palsy within framework of World Health Organization Family International Classifications using systematic review. Methods:Literatures were retrieved and reviewed from the databases of Cochrane Library, PEDro, PubMed, EMBASE, Web of Knowledge, Web of Science, OVID, EBSCO, CMCI, CNKI, Wangfang and VIP until May, 2020. The randomized controlled trials (RCTs) about aquatic therapeutic exercise for children and youth with cerebral palsy for functioning were systematically reviewed. The data were analyzed with RevMan 5.3. Results:Nine RCTs were selected, including 162 children and youth. The score of Gross Motor Function Measure improved significantly after aquatic exercise (WMD = 6.31, 95 %CI 2.57 to 10.06, P < 0.001), as well as daily activities and quality of life. Conclusion:Aquatic therapeutic exercise can help improve the gross motor function of children and youth with cerebral palsy, and has positive effects on function of activity and quality of life.