1.Clinical Case Conference.
Ra Yeon HA ; Hyun Sang CHO ; Duk In JON ; Kyooseob HA
Journal of Korean Neuropsychiatric Association 2010;49(3):272-281
No abstract available.
2.Milium-like Syringoma with Typical Histopathologic Features.
Yeon Soo KANG ; Sang Hyun CHO ; Jeong Duk LEE
Korean Journal of Dermatology 2012;50(8):751-752
No abstract available.
Syringoma
3.A Case of Adrenocortical Carcinoma with Remarkably High Concentrations of 11-dexycortisol.
Hong Seung KIM ; Choon Hee CHUNG ; Mee Yeon CHO ; Mi Duk LEE ; Young Wook KIM ; Yun Mi KIM
Journal of Korean Society of Endocrinology 1998;13(2):271-279
The adrenocartical carcinoma is a rare tumor with an estimated incidence of 1 case per 1,700,000 population. Despite its rarity, a large number of investigators have studied this neoplasm for the following two reasons. The First is the occasional difficulty of differentiation between careinoma and adenoma at the time of initial surgery, even by histopathologic examination. The other is its unique feature of corticosteroidogenesis. Steroid metabolism of adrenocortieal carcinoma is characterized by its low efficiency of steroid production due to deficiency of steroidogenic enzyme. The deficieney of 11 B-hydroxylase has been indieated in case of adrenoeortical carcinoma by several investigators. In this study, the serum level of cortisol was within normal range, but the serum level of 11-deoxycortisol was 50 times higher than normal. After the removal of tumor, the serum level of ll-deoxycortisol was markedly decm. In conclusion, the results from the this case suggest that measurement of serum 11-deoxy- cortisol may be a useful tool in the diagnosis and follow-up of adrenocortical carcinoma.
Adenoma
;
Adrenocortical Carcinoma*
;
Cortodoxone
;
Diagnosis
;
Follow-Up Studies
;
Humans
;
Hydrocortisone
;
Incidence
;
Metabolism
;
Reference Values
;
Research Personnel
4.Association between body mass index and the BEPSI K score of the adolescent in an urban area.
Han Jun CHO ; Soon Duk CHOI ; Weon Young LEE ; Dong Yung CHO ; Beong Yeon YOO
Journal of the Korean Academy of Family Medicine 2001;22(5):698-708
BACKGROUND: The pathological significance of adolescent obesity is increasing, as research results indicate that about 80 percent of obese teenager becomes obese as adults. However, most studies on obesity have been mainly centered on the biomolecular aspect of obesity, thereby offering little solution to the clinical application and the promotion of overall health for people. This study investigates into the psychological factors of adolescent obesity, mainly that relating to stress. METHODS: After having chosen 14 third year classes from two middle schools, one from the Kang nam and the other from the Kang puk region of Seoul, I have distributed questionnaires to the total of 501 students. For calculating the degree of stress among the students, I have employed the BEPSI (Brief Encounter Psychosocial Instrument) K, transforming each 5 positive questions into 1 point, which were summed up and divided by 5 (the BEPSI K score). RESULTS: Controlling the confounding factor, the regression coefficient regarding the Body Mass Index of the BEPSI K score was 0.661, t as 3.122, and R Square as 0.05, indicating the statistical relevance of the two factors. A multiple linear regression analysis of theses data yielded the following equation: Body Mass Index=15.6+0.661 x BEPSI K score(R2=0.05) Although the R Squre, as 0.05, was relatively low, this statistical result proves that the rise in stress contributes to the increase of Body Mass Index, thereby indicating that stress functions as an important factor for adolescent obesity. CONCLUSION: For remedying and preventing adolescent obesity, one must make use of the BEPSI K examination and calculate the degree of stress among the adolescent. This study further implies that the best solution to the problems of obesity among adolescent is for the family members, the educational institutions, and the society as a whole to understand and to help the adolescent overcome frequent mental stress resulting from their daily living.
Adolescent*
;
Adult
;
Body Mass Index*
;
Humans
;
Linear Models
;
Obesity
;
Pediatric Obesity
;
Psychology
;
Seoul
;
Surveys and Questionnaires
5.Quantitative EEG Analysis in Atypical Rolandic Epilepsies of Childhood.
Jeeyoung OH ; Hyang Woon LEE ; Hyunji CHO ; Kyoung Gyu CHOI ; Kee Duk PARK ; Jeong Yeon KIM
Journal of Korean Epilepsy Society 2005;9(1):53-58
PURPOSE: Benign childhood epilepsy with centrotemporal spikes (BCECT) or benign rolandic epilepsy (BRE) is not always benign in clinical or neuroimaging features. Recent studies have reported atypical forms of rolandic epilepsy with abnormal neurologic and/or neuroimaging findings, sometimes, also with poor seizure control. We investigated whether there are any differences in linear and nonlinear EEG analysis in typical and atypical rolandic epilepsies of childhood. METHODS: Ten patients with typical BRE group and seven patients with atypical BRE group were included in this study. We selected artifact-free 10-second epochs from 19 electrodes of 10-20 international EEG system from each patient. The power spectrum was calculated in delta, theta, alpha, beta, and gamma frequency ranges. The fractal dimension was analyzed as a nonlinear EEG analysis. We analyzed both EEGs with interictal spikes and without focal slowing or epileptiform activities. RESULTS: The spectral EEG analysis showed a significant increase of absolute and relative power of delta with decrease of alpha bands in atypical BRE group compared to typical group. There was no statistical difference in fractal dimension between the two groups. CONCLUSION: Atypical BRE group showed enhanced delta and decreased alpha power, suggesting a cortical dysfunction in this group with poor clinical outcome.
Electrodes
;
Electroencephalography*
;
Epilepsy
;
Epilepsy, Rolandic*
;
Fractals
;
Humans
;
Neuroimaging
;
Seizures
6.Menin represses JunD transcriptional activity in protein kinase Ctheta-mediated Nur77 expression.
Hyungsoo KIM ; Ji Eun LEE ; Bu Yeon KIM ; Eun Jung CHO ; Seong Tae KIM ; Hong Duk YOUN
Experimental & Molecular Medicine 2005;37(5):466-475
TCR signaling leading to thymocyte apoptosis is mediated through the expression of the Nur77 family of orphan nuclear receptors. It has been shown that the Nur77 promoter is activated by at least two signaling pathways, one mediated by calcium and the other by protein kinase C (PKC). MEF2D has been known to regulate Nur77 expression in a calcium- dependent manner. The mechanism by which calcium regulates MEF2D is through dissociation of calcium-sensitive MEF2 corepressors (Cabin1/ HDACs, HDAC4/5) and the association with calcineurin-activated transcription factor NF-AT and the coactivator p300. However, little is known about how PKC activates the Nur77 promoter. Herein, we report that PKC theta targets AP-1 like response element in the Nur77 promoter where JunD constitutively binds. PKC theta triggers mitogen-activated protein kinase- inediated phosphorylation of JunD, and increases transcriptional activity of JunD, cooperatively with p300. Menin is identified as the transcriptional corepressor for JunD via recruitment of mSin3-istone deacetylases. In fact, Menin represses PKC theta/ p300-mediated transcriptional activity of JunD in T cell. Its dynamic regulation of histone modifiers with JunD is responsible for PKCq-synergistic effect on Nur77 expression in T cell.
Cell Line, Tumor
;
DNA-Binding Proteins/*genetics
;
Enzyme Activation
;
*Gene Expression Regulation
;
Humans
;
Isoenzymes/*metabolism
;
Mitogen-Activated Protein Kinases/metabolism
;
*Multiple Endocrine Neoplasia Type 1
;
Promoter Regions (Genetics)/genetics
;
Protein Kinase C/*metabolism
;
Proto-Oncogene Proteins/genetics/*metabolism
;
Proto-Oncogene Proteins c-jun/*antagonists & inhibitors/metabolism
;
Receptors, Cytoplasmic and Nuclear/*genetics
;
Receptors, Steroid/*genetics
;
Research Support, Non-U.S. Gov't
;
Response Elements
;
Transcription Factors/*genetics
;
Transcription, Genetic/*genetics
7.Effects of Rho Kinase Inhibitor on Detrusor Overactivity after Bladder Outlet Obstruction in Rats.
Hyun Woo KIM ; Su Yeon CHO ; Duk Jin PARK ; Byung Il YOON ; Ji Youl LEE
Korean Journal of Urology 2007;48(8):832-837
PURPOSE: A partial bladder outlet obstruction(PBOO) related detrusor hypertrophy is associated with up-regulation of the Rho kinase activity in an experimental animal model, and has been implicated in PBOO induced bladder dysfunction. The effect of a Rho kinase inhibitor on the voiding function in anesthetized rats with PBOO was investigated. MATERIALS AND METHODS: Eighteen Sprague-Dawley rats were divided into control(9 rats) and experimental(9 rats) groups. The experimental group was partially obstructed for 6 weeks, with cystometrograms(CMG) then were performed. The number of voids, and the intercontraction interval (ICI) and peak pressure(PP) were recorded. Rho kinase inhibitors were administered to the experimental group. An additional CMG was performed to observe the effects of Rho kinase inhibition. Bladder tissues were immunohistochemically(IHC) evaluated for the expression of RhoA protein. RESULTS: The bladder weights of the PBOO group were significantly increased compared with the control group(p<0.05). Significant increases in the voiding frequency and PP, but a significant decrease in the ICI was observed in the PBOO group compared to the control group on the CMG (p<0.05). The voiding frequency of the PBOO group was significantly decreased after Rho kinase inhibitor treatment(p<0.05). The Rho kinase inhibitor treated group showed a decrease in the PP and an increase in the ICI compared to the PBOO group. The IHC showed a higher RhoA protein expression in the bladder tissues of the PBOO group. CONCLUSIONS: H-1152, a specific inhibitor of Rho kinase, attenuates the PBOO-related detrusor overactivity in a rat model. The Rho kinase inhibitor appears to be a novel strategy for the management of bladder overactivity.
Animals
;
Hypertrophy
;
Models, Animal
;
Rats*
;
Rats, Sprague-Dawley
;
rho-Associated Kinases*
;
rhoA GTP-Binding Protein
;
Up-Regulation
;
Urinary Bladder Neck Obstruction*
;
Urinary Bladder*
;
Weights and Measures
8.Adenoid Basal Carcinoma and Adenoid Cystic Carcinoma of the Uterine Cervix: A Study of 2 Cases.
Hee Hwan CHUNG ; Jong Min LEE ; Ji Sung LEE ; Yong Yook KIM ; Gil Nam ROH ; Yu Duk CHOI ; Seung Yeon HA ; Hyun I CHO
Korean Journal of Obstetrics and Gynecology 1999;42(8):1877-1881
Adenoid basal carcinoma and adenoid cystic carcinoma of the uterine cervix are rare tumors that have often been regarded as a single entity. But adenoid basal and adenoid cystic carcinomas of the cervix differ from each other in their histology, treatment, and prognosis. We experienced 2 cases of these neoplasms, with 1 case in each category. Whereas adenoid basal carcinoma is a slow-growing, locally invasive lesion amenable to simply hysterectomy, adenoid cystic carcinoma is an aggressive tumor associated with regional lymph node involvement and late distant metastases. This study reviews the literature and formulates a program for the management of these rare lesions.
Adenoids*
;
Carcinoma, Adenoid Cystic*
;
Cervix Uteri*
;
Female
;
Hysterectomy
;
Lymph Nodes
;
Neoplasm Metastasis
;
Prognosis
9.Prospective Comparative Analysis of the Incidence of Vasovagal Reaction and the Effect of Rectal Submucosal Lidocaine Injection in Stapled Hemorrhoidopexy: A Randomized Controlled Trial
Kyung Jin CHO ; Do Yeon HWANG ; Hyun Joo LEE ; Ki Hoon HYUN ; Tae Jung KIM ; Duk Hoon PARK
Annals of Coloproctology 2020;36(5):344-348
Purpose:
This study was performed to evaluate the incidence of vasovagal reactions (VVRs) and the efficacy of lidocaine injection for prevention.
Methods:
One hundred seventeen patients diagnosed with hemorrhoids and scheduled to undergo a stapled hemorrhoidopexy (SH) were randomly divided according to submucosal injection to the rectum: lidocaine group (n = 53, lidocaine injected just before full closure of the stapler) and control group (n = 58). Outcomes included baseline patient characteristics (American Society of Anesthesiologists physical status classification, body mass index, diabetes mellitus, hypertension, and previous VVR history), vital signs during the operation, incidence of VVRs (hypotension, bradycardia, dizziness, diaphoresis, and nausea/vomiting), and postoperative complications (pain, bleeding, and urinary retention).
Results:
Baseline characteristics were similar between groups. The number of patients with lower abdominal pain after firing the stapler and incidence of dizziness were lower for the lidocaine group than for the control group (9.4% vs. 25.9%, P = 0.017; 0% vs. 8.6%, P = 0.035, respectively). However, there were no significant between-group differences in incidence of nausea and diaphoresis (0% vs. 3.4%, P = 0.172) and syncope (1.9% vs. 3.4%, P = 0.612). Fewer patients in the lidocaine group complained of postoperative pain (41.5% vs. 58.6%, P = 0.072), and these patients used analgesics less frequently than those in the control group (28.3% vs. 36.2%, P = 0.374).
Conclusion
Patients who received a submucosal lidocaine injection prior to SH experienced less lower abdominal pain and dizziness compared with those who received standard treatment. A larger, more detailed prospective study is needed for further analysis.
10.Glucose-Dependent Insulinotropic Peptide Level Is Associated with the Development of Type 2 Diabetes Mellitus.
Sunghwan SUH ; Mi Yeon KIM ; Soo Kyoung KIM ; Kyu Yeon HUR ; Mi Kyoung PARK ; Duk Kyu KIM ; Nam H CHO ; Moon Kyu LEE
Endocrinology and Metabolism 2016;31(1):134-141
BACKGROUND: Incretin hormone levels as a predictor of type 2 diabetes mellitus have not been fully investigated. Therefore, we measured incretin hormone levels to examine the relationship between circulating incretin hormones, diabetes, and future diabetes development in this study. METHODS: A nested case-control study was conducted in a Korean cohort. The study included the following two groups: the control group (n=149), the incident diabetes group (n=65). Fasting total glucagon-like peptide-1 (GLP-1) and total glucose-dependent insulinotropic peptide (GIP) levels were measured and compared between these groups. RESULTS: Fasting total GIP levels were higher in the incident diabetes group than in the control group (32.64±22.68 pmol/L vs. 25.54±18.37 pmol/L, P=0.034). There was no statistically significant difference in fasting total GLP-1 levels between groups (1.14±1.43 pmol/L vs. 1.39±2.13 pmol/L, P=0.199). In multivariate analysis, fasting total GIP levels were associated with an increased risk of diabetes (odds ratio, 1.005; P=0.012) independent of other risk factors. CONCLUSION: Fasting total GIP levels may be a risk factor for the development of type 2 diabetes mellitus. This association persisted even after adjusting for other metabolic parameters such as elevated fasting glucose, hemoglobin A1c, and obesity in the pre-diabetic period.
Case-Control Studies
;
Cohort Studies
;
Diabetes Mellitus, Type 2*
;
Fasting
;
Gastric Inhibitory Polypeptide*
;
Glucagon-Like Peptide 1
;
Glucose
;
Incretins
;
Multivariate Analysis
;
Obesity
;
Risk Factors