1.Thyroiditis radioisotope scan findings and clinical significance.
Jong Chae KIM ; Duck Sup HAN ; Jung Suck PARK ; Se Jong KIM ; Byung Lan PARK ; Byoung Geun KIM
Korean Journal of Nuclear Medicine 1991;25(2):280-285
No abstract available.
Thyroid Gland*
;
Thyroiditis*
2.Comparison of L1 consensus primers with E6 type specific primers for detection of human papillomaviruses in paraffin sections of cervical neoplasia.
Jong Sup PARK ; Sung Eun NAMKOONG ; Sang Kyun HAN ; Duck Jin NHA ; Hun Yong LEE ; Seung Jo KIM
Journal of Korean Medical Science 1993;8(1):60-67
In our comparative study of L1 consensus primers with E6 type-specific primers for detection of human papillomavirus (HPVs) by polymerase chain reaction (PCR) in 35 cases of cervical neoplasia, the detection rate by E6 primers (54%; 19/35) was significantly higher than that by L1 primers (25%; 9/35) (p < 0.01). And all specimens HPV-positive with L1 primers were also positive by E6 primers. HPV DNA could be amplified in 36% (9 of 25) of tissue by L1 consensus primers from which beta-globin gene was amplified as compared with 64% (16 of 25) of tissue by E6 type-specific primers. With the L1 consensus primers, 8 cases were positive for HPV-16 and 1 case was positive for HPV-33. These results show that the L1 consensus primers have inferior sensitivity to the E6 type-specific primers for the detection of HPV by PCR. But the L1 consensus primers have great value in making simultaneous detection of various HPV types in a single tube reaction, thus they permit reduction of time and the economic burden of the experiment.
Base Sequence
;
DNA, Viral/analysis
;
Female
;
Humans
;
Molecular Sequence Data
;
Oligodeoxyribonucleotides
;
Papillomaviridae/genetics/*isolation & purification
;
*Polymerase Chain Reaction
;
Uterine Cervical Neoplasms/*microbiology
3.Nocardiosis Following Renal Transplantation.
Tae Hee KIM ; Song Chol KIM ; Joon Hong SOHN ; Heung Sup SUNG ; Mi Na KIM ; Duck Jong HAN
The Journal of the Korean Society for Transplantation 2001;15(2):208-216
PURPOSE: Infection with Nocardia species is an uncommon yet important cause of morbidity and mortality in renal transplant recipients. METHODS: We experienced 6 cases of nocardiosis among 239 renal transplant recipients maintained on tacrolimus- or cyclosporine-based immunosuppression from May 1999 to February 2001. RESULTS: All the six patients had pulmonary nocardiosis from 36 to 220 (mean 82) days after renal transplantation. Due to a multiplicity of infection sites, cerebral abscess was detected in 2 patients, soft tissue abscess in 2, allograft abscess in 1 and subretinal abscess in 1. Comparing the routine trimethoprim/ sulfamethoxazole (TMP/SMX) prophylaxis after transplantation, 5 out of 6 patients took TMP/SMX for a mean of 1.8 months due to an increased AST/ALT. All the cases required invasive diagnostic procedures such as percutaneous needle aspiration (PC NA) or stereotactic aspiration. In the antimicrobial susceptibility test, isolates were sensitive to TMP/SMX, amikacin and imipenem. In the early stage of infection, we used triple chemotherapy (TMP/SMX, amikacin, imipenem) for cerebral nocardiosis and dual therapy (TMP/SMX, amikacin) for localized pulmonary infection. There were no mortality and all the graft maintained stable function. CONCLUSION: After organ transplantation, pneumonia accompanied with satellite soft tissue infection should be considered as a nocardiosis. Pro- phylactic use of TMP/SMX is crucial for effective prevention of nocardiosis.
Abscess
;
Allografts
;
Amikacin
;
Brain
;
Brain Abscess
;
Drug Therapy
;
Humans
;
Imipenem
;
Immunosuppression
;
Kidney Transplantation*
;
Mortality
;
Needles
;
Nocardia
;
Nocardia Infections*
;
Organ Transplantation
;
Pneumonia
;
Soft Tissue Infections
;
Sulfamethoxazole
;
Transplantation
;
Transplants
4.Clinical Features of Pseudoaneurysms Complicating Pancreatitis: Single Center Experience and Review of Korean Literature.
Ji Hyun KIM ; Jae Seon KIM ; Chang Duck KIM ; Hong Sik LEE ; Young Jig CHO ; Jong Sup LEE ; Do Won CHOI ; Woo Sik HAN ; Youn Ho KIM ; Jong Eun YEON ; Jong Jae PARK ; Kwan Soo BYUN ; Young Tae BAK
The Korean Journal of Gastroenterology 2007;50(2):108-115
BACKGROUND/AIMS: Pseudoaneurysm is a life-threatening complication of chronic or acute pancreatitis. This study was undertaken to evaluate the clinical features of pseudoaneurysm complicating pancreatitis. METHODS: We reviewed the medical records of 7 patients diagnosed as pseudoaneurysms with chronic pancreatitis in Korea University Guro and Anam Hospital from January 1995 to March 2006 and analyzed their demographics, clinical courses and outcomes. RESULTS: All patients were men and mean age was 54.6 years (range, 43-67 years). All the cases occurred in the setting of chronic alcoholic pancreatitis complicated by pseudocyst. Abdominal pain was the unique initial clinical symptom in 5 cases, hematemesis in 1 case, and simultaneous abdominal pain with hematemesis in 1 case. Bleeding into pseudocyst developed in 5 cases, flowing into duodenum through pancreatic duct in 1 case and rupture into the descending colon in 1 case. Mean duration between onset of symptom and diagnosis of pseudoaneurysm was 7.8 days (range, 1-23 days). Six cases were diagnosed by abdominal computed tomography disclosing characteristic finding of focal high density area in the pseudocyst. Pulsed doppler abdominal sonography was performed before computed tomography in 3 cases and results were negative in 2 cases. Transcatheter arterial embolizations were initially performed in 6 cases, and there was no recurrent bleeding except one case of splenic infarction. Distal pancreatectomy was initially performed in 1 case. CONCLUSIONS: Pseudoaneurysms complicating chronic pancreatitis shows various clinical features. Transcatheter arterial embolization can be recommended as a primary therapeutic modality.
Adult
;
Aged
;
Aneurysm, False/*diagnosis/etiology/ultrasonography
;
Arteries/injuries
;
Demography
;
Embolization, Therapeutic
;
Hemorrhage/etiology/surgery
;
Humans
;
Korea
;
Male
;
Middle Aged
;
Pancreatic Pseudocyst/etiology/surgery
;
Pancreatitis, Alcoholic/*complications/pathology
;
Retrospective Studies
;
Tomography, X-Ray Computed
5.Conscious Sedation with Midazolam Combined with Propofol for Colonoscopy.
Ja Seol KOO ; Jai Hyun CHOI ; Sung Woo JUNG ; Woo Sik HAN ; Jong Sup LEE ; Hyung Joon YIM ; Yoon Tae JEEN ; Hoon Jai CHUN ; Hong Sik LEE ; Sang Woo LEE ; Chang Duck KIM ; Ho Sang RYU
Korean Journal of Gastrointestinal Endoscopy 2007;34(6):298-303
BACKGROUND/AIMS: There is increasing interest in the use of propofol as a sedative agent for colonoscopy. We evaluated the safety and efficacy of the synergistic sedation with midazolam combined with low-dose propofol versus that of midazolam alone. METHODS: A total of 56 patients from among those who underwent total colonoscopy between August 2004 and October 2004 were randomly assigned to one of three medication treatment groups. Group A (n=18) received low-dose midazolam (0.03 mg/kg IV) plus propofol, group B (n=19) received high-dose midazolam (0.07 mg/kg IV) plus propofol, and group C (n=19) received high-dose midazolam alone. The patients' vital signs were monitored throughout the course of the study. The recovery time and quality as well as the patients' comfort level were also assessed. RESULTS: There were no significant differences in baseline characteristics among the treatment groups. There were also no differences in the duration and insertion time of the colonoscopy among the three groups. The patients' comfort level and cardiorespiratory parameters during colonoscopy were similar among the three groups. The sedation efficacy and recovery times were also similar among the three groups. CONCLUSIONS: Midazolam combined with low-dose propofol as a sedative for colonoscopy exhibits similar effects on safety, patient' comfort level and recovery time to those of midazolam alone.
Colonoscopy*
;
Conscious Sedation*
;
Humans
;
Midazolam*
;
Propofol*
;
Vital Signs
6.A Case of Peripheral Ischemic Complication after Terlipressin Therapy.
Jong Sup LEE ; Hong Sik LEE ; Sung Woo JUNG ; Woo Sik HAN ; Min Jeong KIM ; Sang Woo LEE ; Jai Hyun CHOI ; Chang Duck KIM ; Ho Sang RYU ; Jin Hai HYUN
The Korean Journal of Gastroenterology 2006;47(6):454-457
Hepatorenal syndrome is a severe complication of cirrhosis, leading to death in more than 90% of cases in the absence of liver transplantation. Several treatments have been attempted as a bridge to liver transplantation. Among such treatments, terlipressin is a nonselective V1 vasopressin agonist. When comparing with ornipressin, it is known to have a similar vasoconstricting potency, but much less ischemic complication. We report a case of gangrene on toes and necrosis on the infusion site of left hand which developed after the use of terlipressin due to hepatorenal syndrome in a 41-year-old-man with liver cirrhosis. Ischemic complication of terlipressin is rare and there has been no case report in Korea. Although it is rare, we must pay attention to the peripheral ischemic complication of terlipressin.
Adult
;
Hand/*blood supply
;
Hepatorenal Syndrome/drug therapy
;
Humans
;
Ischemia/*chemically induced
;
Lysine Vasopressin/adverse effects/*analogs & derivatives/therapeutic use
;
Male
;
Toes/*blood supply
;
Vasoconstrictor Agents/*adverse effects/therapeutic use
7.Usefulness of Endoscopic Ultrasonography for Diagnosing Choledocholithiasis in Patients with Gallbladder Stones.
Ja Seol KOO ; Hong Sik LEE ; Sung Woo JUNG ; Woo Sik HAN ; Jong Sup LEE ; Hyung Joon YIM ; Sang Woo LEE ; Jai Hyun CHOI ; Chang Duck KIM ; Ho Sang RYU
Korean Journal of Gastrointestinal Endoscopy 2007;35(4):228-234
BACKGROUND/AIMS: CBD stones (CBDS) are generally thought to originate from the gallbladder. Recently, EUS appears to be the best imaging method for making the diagnosis of CBDS. We conducted this study to evaluate the role of EUS for detecting CBDS in patients with gallbladder stones (GBS) and to determine the parameters for predicting CBDS. METHODS: From April 2003 to March 2005, 117 GBS patients were enrolled. The patients' clinical and laboratory findings and the radiologic findings of US, EUS, CT and ERCP were reviewed. The sensitivity, specificity, PPV and NPV of EUS for detecting CBDS were evaluated by using ERCP and intraoperative CBD exploration as the gold standard for diagnosing CB. RESULTS: A total 117 patients received EUS and no complications were encountered. After performing ERCP and/or intraoperative exploration, 62 of the patients were examined for determining the presence or absence of CBDS. EUS shows 95% sensitivity and 95% specificity for identifying CBDS. The overall agreement between EUS and ERCP was 94.8%. The patients with CBDS were older than those without CBDS. Fever, jaundice and cholangitis were more prevalent in the patients with CBDS. The results of liver function tests were elevated more frequently in the patients with CBDS (p<0.05). CONCLUSIONS: EUS is an accurate and minimally invasive method for diagnosing CBDS. Evaluating CBD in patients with gallstones is selectively recommended according to clinical and laboratory findings.
Cholangiopancreatography, Endoscopic Retrograde
;
Cholangitis
;
Choledocholithiasis*
;
Diagnosis
;
Endosonography*
;
Fever
;
Gallbladder*
;
Gallstones
;
Humans
;
Jaundice
;
Liver Function Tests
;
Sensitivity and Specificity
8.Analysis of Clinical Features and Factors Predictive of Malignancy in Intraductal Papillary Mucinous Tumor of the Pancreas: Multi-center Analysis in Korea.
Jin Young JANG ; Sun Whe KIM ; Young Joon AHN ; Yoo Seok YOON ; Kuhn Uk LEE ; Young Joo LEE ; Song Chul KIM ; Gee Hun KIM ; Duck Jong HAN ; Yong Il KIM ; Seong Ho CHOI ; Baik Hwan CHO ; Hee Chul YU ; Byong Ro KIM ; Dong Sup YOON ; Woo Jung LEE ; Kyung Bum LEE ; Young Chul KIM ; Kwang Soo LEE ; Kyeong Geun LEE ; Young Kook YUN ; Soon Chan HONG ; Koo Jeong KANG ; Tae Jin LIM ; Kyong Woo CHOI ; Yong Oon YOO ; Jong Hun PARK ; Young Hoon KIM ; Mun Sup SIM ; Hyung Chul KIM ; Chang Ho KIM ; Man Kyu CHAE ; Hong Yong KIM ; Young Gil CHOI ; Wook Hwan KIM ; Myung Wook KIM ; Hong Jin KIM ; Kwon Mook CHAE ; Dong Wook CHOI ; Sang Beom KIM ; Ho Seong HAN ; Seung Ik AHN ; Kuk Hwan KWON ; Chul Gyun JO ; Hyun Jong KIM ; Jae Woon CHOI ; Jong Riul LEE ; Joo Seop KIM ; Yong Hyun PARK
Korean Journal of Hepato-Biliary-Pancreatic Surgery 2003;7(1):1-11
BACKGROUND/AIMS: Despite of increasing numbers of reports on intraductal papillary mucinous tumor (IPMT), there is still difficulty in its' diagnosis, treatment and prediction of prognosis. The purpose of this multicenter study was to evaluate the clinico-pathological features of IPMT in Korea and suggest the prediction criteria of malignancy in IPMT. METHODS: We retrospectively reviewed the clinico-pathological data of 208 patients who underwent operations with IPMT between 1993 and 2002 at 28 institutes in Korea. RESULTS: Of the 208 patients with a mean age of 60.5+/-9.7 years, 147 were men and 61 were women. 124 patients underwent pancreatoduodenectomy, 42 distal pancreatectomy, 17 total pancreatectomy, 25 limited pancreas resection. Benign cases were 128 (adenoma (n=62), borderline (n=66)) and malignant cases were 80 (non-invasive (n=29), invasive (n=51)). A significant difference in 5-year survival was observed between benign and malignant group (92.6% vs. 65.3%; p=0.006). Of the 6 factors (age, location, duct dilatation, tumor appearance, main duct type, and tumor size) that showed the statistical difference in univariate analysis between benign and malignant group, we found three significant factors (tumor appearance (p=0.009), tumor size (p=0.023), and dilated duct size (p=0.010)) by multivariate analysis. CONCLUSION: Although overall prognosis of IPMT is superior to ordinary pancreatic cancer, more curative surgery is recommended in malignant IPMT. Tumor appearance (papillary), tumor size (> or =30 mm) and dilated duct size (> or = 12 mm) can be used as preoperative indicators of malig-nancy in IPMT.
Academies and Institutes
;
Diagnosis
;
Dilatation
;
Female
;
Humans
;
Korea*
;
Male
;
Mucins*
;
Multivariate Analysis
;
Pancreas*
;
Pancreatectomy
;
Pancreatic Neoplasms
;
Pancreaticoduodenectomy
;
Prognosis
;
Retrospective Studies