1.A study on the analysis of aflatoxin B in human sera by ELISA.
Eui Chul JUNG ; Woo Song HA ; Soon Tae PARK ; Sang Kyung CHOI ; Soon Chan HONG ; Ho Seong HAN ; Duck Hwa JUNG
Journal of the Korean Surgical Society 1992;42(4):419-428
No abstract available.
Aflatoxin B1*
;
Aflatoxins*
;
Enzyme-Linked Immunosorbent Assay*
;
Humans*
2.Botulinum Toxin Treatment on Upper Limb Function in School Age Children With Bilateral Spastic Cerebral Palsy: One Year Follow-up.
Jee Sun LEE ; Kyu Bum LEE ; Yu Ryun LEE ; You Nam CHOI ; Chul Woo PARK ; Sang Duck PARK ; Dong Hwa JUNG ; Chul Sang LEE
Annals of Rehabilitation Medicine 2013;37(3):328-335
OBJECTIVE: To prospectively investigate the long-term effects of botulinum toxin treatment on the upper limb function and performance of school age children with spastic bilateral cerebral palsy, who have limitations in performing activities of daily living and school activities, due to spasticity of the upper extremities. METHODS: Botulinum type A toxin (BoNT-A) was injected into 24 spastic upper limbs of 15 children. We used a Modified Ashworth Scale and a Modified Tardieu Scale for the evaluation of upper limb spasticity, and Quality of Upper Extremity Skills Test (QUEST), Canadian Occupational Performance Measure (COPM), and Test of Visual-Motor Skills-Revised (TVMS-R) for the evaluation of upper limb function and performance. RESULTS: Upper limb spasticity continuously decreased until the end of the one-year follow-up. Upper limb function on QUEST and COPM showed the best performance at 3 months and deteriorated slightly, but still showed a significantly better performance at 9 and 12 months than at pre-injection. In more functional nine subjects who could perform TVMS-R, the performance enhancement effects remained constant after 12 months, suggesting that the reduced spasticity led to the learning effect acquired by the repeated use of the affected upper limb. CONCLUSION: For school age children with bilateral spastic cerebral palsy whose upper limb functions are important, BoNT-A injections seem to be of help in the performance of school activities and activities of daily living.
Activities of Daily Living
;
Botulinum Toxins
;
Botulinum Toxins, Type A
;
Cerebral Palsy
;
Child
;
Follow-Up Studies
;
Humans
;
Learning
;
Muscle Spasticity
;
Prospective Studies
;
Upper Extremity
3.A Case of Squamous Cell Carcinoma of Bartholin's Gland.
Duck Yeong RO ; Hwa Jeong SHIN ; Gil Joong KIM ; Ji Young KWON ; Cheol Hoon PARK ; Yong Wook KIM ; Tae Eung KIM ; Jae Keun JUNG
Korean Journal of Obstetrics and Gynecology 2002;45(9):1595-1600
Carcinomas of Bartholin's gland are rare tumors that account for less than 1% of all gynecological malignancies. Two major histological types, squamous cell carcinoma and adenocarcinoma, account for 80% to 90% of primary cases. The remainders are adenosquamous carcinoma, adenoid cystic carcinoma and so on. We experienced a case of squamous cell carcinoma of the Bartholin's gland managed by wide local excision and chemotherapy with cisplatin and 5-fluorouracil (5-FU). We present this case with a brief review of the literatures.
Adenocarcinoma
;
Carcinoma, Adenoid Cystic
;
Carcinoma, Adenosquamous
;
Carcinoma, Squamous Cell*
;
Cisplatin
;
Drug Therapy
;
Fluorouracil
4.A Case of Leiomyoma of the Ovary.
Hwa Jeong SHIN ; Hee Jeong YU ; Cheol Hoon PARK ; Tae Eung KIM ; Jae Keun JUNG ; Duck Yeong RO ; Kyung Mi KIM
Korean Journal of Obstetrics and Gynecology 2005;48(3):784-787
Leiomyoma arising primarily in the ovary is a rare tumor, accounting for only 1% of benign ovarian neoplasms. About 50 cases have been reported in the literature to date. Most cases are asymptomatic and this benign neoplasm is usually found incidentally on routine pelvic examination, at surgery, or at autopsy. We present a case of ovarian leiomyoma in 39-year-old woman which has been experienced in our hospital with brief review of literature.
Adult
;
Autopsy
;
Female
;
Gynecological Examination
;
Humans
;
Leiomyoma*
;
Ovarian Neoplasms
;
Ovary*
5.Liver Abscess in Advanced Hepatocellular Carcinoma after Sorafenib Treatment.
Seung Kak SHIN ; Young Kul JUNG ; Hyun Hwa YOON ; Oh Sang KWON ; Yun Soo KIM ; Duck Joo CHOI ; Ju Hyun KIM
The Korean Journal of Gastroenterology 2014;63(1):47-50
Hepatocellular carcinoma (HCC) is a critical global health issue and the third most common cause of cancer-related deaths worldwide. The majority of patients who present HCC are already at an advanced stage and their tumors are unresectable. Sorafenib is a multi-kinase inhibitor of the vascular endothelial growth factor pathway and was recently introduced as a therapy for advanced HCC. Furthermore, studies have shown that oral sorafenib has beneficial effects on survival. However, many patients experience diverse side effects, and some of these are severe. Liver abscess development has not been previously documented to be associated with sorafenib administration in HCC. Here, we report the case of a HCC patient that developed a liver abscess while being treated with sorafenib.
Anti-Bacterial Agents/therapeutic use
;
Antineoplastic Agents/adverse effects/*therapeutic use
;
Carcinoma, Hepatocellular/*drug therapy/radiography
;
Clostridium/isolation & purification
;
Clostridium Infections/drug therapy/microbiology
;
Humans
;
Liver Abscess/etiology/*microbiology
;
Liver Neoplasms/*drug therapy/radiography
;
Male
;
Middle Aged
;
Niacinamide/adverse effects/*analogs & derivatives/therapeutic use
;
Phenylurea Compounds/adverse effects/*therapeutic use
;
Tomography, X-Ray Computed
6.The Effect of Epicatechin on the High Glucose-induced TSP-1 Expression and MMP-2 Activity in Rat Vascular Smooth Muscle Cells.
Gyeong Ryul RYU ; Jung Hoon KANG ; Kyong Ja HONG ; In Kyung JEONG ; Hwa In JANG ; Duck Joo RHIE ; Shin Hee YOON ; Sang June HAHN ; Myung Suk KIM ; Yang Hyeok JO ; Myung Jun KIM
Journal of Korean Society of Endocrinology 2006;21(4):302-310
BACKGROUND: The incidence of atherosclerosis is well correlated with the progression of type 2 diabetes mellitus. High plasma glucose in uncontrolled diabetic patients evokes many vascular complications such as atherosclerosis. Specifically, high glucose was reported to induce thrombospondin-1 (TSP-1), which activates matrix metalloproteinase-2 (MMP-2) and leads to the invasion of vascular smooth muscle cells (VSMCs) into the intima. Catechins with antioxidant effects are known to inhibit MMP-2 activity. Therefore, this study was aimed at revealing the effect of epicatechin, one of catechins, on high glucose-induced TSP-1 and the invasiveness of VSMCs. METHODS: VSMCs were primarily isolated from Sprague-Dawley rat aorta. The VSMCs were incubated with different doses (30, 100 and 300 micrometer) of epicatechin under high glucose concentration (30 mM). The TSP-1 protein and mRNA expressions were analyzed by performing Western blotting and Northern blot analyses, respectively. RT-PCR was performed to observe the MMP-2 mRNA expression. Gelatin zymography was performed for the measurement of MMP-2 activity. Invasion assays were performed to evaluate the invasiveness of VSMCs. RESULTS: Epicatechin inhibited the high glucose-induced TSP-1 expression and the MMP-2 activity in a dose-dependent manner. Also, epicatechin inhibited the high glucose-induced invasiveness of VSMCs across the matrix barrier in a dose-dependent fashion. CONCLUSION: Collectively, epicatechin may prevent the high glucose-induced proliferation and invasion of VSMCs by inhibiting the TSP-1 expression and the MMP-2 activity. Therefore, epicatechin appears to play a protective role in the development of atherosclerosis.
Animals
;
Antioxidants
;
Aorta
;
Atherosclerosis
;
Blood Glucose
;
Blotting, Northern
;
Blotting, Western
;
Catechin*
;
Diabetes Mellitus, Type 2
;
Gelatin
;
Glucose
;
Humans
;
Incidence
;
Matrix Metalloproteinase 2
;
Muscle, Smooth, Vascular*
;
Rats*
;
Rats, Sprague-Dawley
;
RNA, Messenger
;
Thrombospondin 1*
7.The Effect of Epicatechin on the High Glucose-induced TSP-1 Expression and MMP-2 Activity in Rat Vascular Smooth Muscle Cells.
Gyeong Ryul RYU ; Jung Hoon KANG ; Kyong Ja HONG ; In Kyung JEONG ; Hwa In JANG ; Duck Joo RHIE ; Shin Hee YOON ; Sang June HAHN ; Myung Suk KIM ; Yang Hyeok JO ; Myung Jun KIM
Journal of Korean Society of Endocrinology 2006;21(4):302-310
BACKGROUND: The incidence of atherosclerosis is well correlated with the progression of type 2 diabetes mellitus. High plasma glucose in uncontrolled diabetic patients evokes many vascular complications such as atherosclerosis. Specifically, high glucose was reported to induce thrombospondin-1 (TSP-1), which activates matrix metalloproteinase-2 (MMP-2) and leads to the invasion of vascular smooth muscle cells (VSMCs) into the intima. Catechins with antioxidant effects are known to inhibit MMP-2 activity. Therefore, this study was aimed at revealing the effect of epicatechin, one of catechins, on high glucose-induced TSP-1 and the invasiveness of VSMCs. METHODS: VSMCs were primarily isolated from Sprague-Dawley rat aorta. The VSMCs were incubated with different doses (30, 100 and 300 micrometer) of epicatechin under high glucose concentration (30 mM). The TSP-1 protein and mRNA expressions were analyzed by performing Western blotting and Northern blot analyses, respectively. RT-PCR was performed to observe the MMP-2 mRNA expression. Gelatin zymography was performed for the measurement of MMP-2 activity. Invasion assays were performed to evaluate the invasiveness of VSMCs. RESULTS: Epicatechin inhibited the high glucose-induced TSP-1 expression and the MMP-2 activity in a dose-dependent manner. Also, epicatechin inhibited the high glucose-induced invasiveness of VSMCs across the matrix barrier in a dose-dependent fashion. CONCLUSION: Collectively, epicatechin may prevent the high glucose-induced proliferation and invasion of VSMCs by inhibiting the TSP-1 expression and the MMP-2 activity. Therefore, epicatechin appears to play a protective role in the development of atherosclerosis.
Animals
;
Antioxidants
;
Aorta
;
Atherosclerosis
;
Blood Glucose
;
Blotting, Northern
;
Blotting, Western
;
Catechin*
;
Diabetes Mellitus, Type 2
;
Gelatin
;
Glucose
;
Humans
;
Incidence
;
Matrix Metalloproteinase 2
;
Muscle, Smooth, Vascular*
;
Rats*
;
Rats, Sprague-Dawley
;
RNA, Messenger
;
Thrombospondin 1*
8.Anti-phospholipase A2 receptor antibody as a prognostic marker in patients with primary membranous nephropathy.
Eun Joo SONG ; Kye Hwa JEONG ; Young Ae YANG ; Jeong Hoon LIM ; Hee Yeon JUNG ; Ji Young CHOI ; Jang Hee CHO ; Chan Duck KIM ; Yong Lim KIM ; Sun Hee PARK
Kidney Research and Clinical Practice 2018;37(3):248-256
BACKGROUND: Phospholipase A2 receptor (PLA2R) has been identified as a major autoantigen in primary membranous nephropathy (MN). We evaluated the association between anti-PLA2R antibodies and clinical outcome in Korean patients with primary MN. METHODS: A total of 66 patients with biopsy-proven MN were included. Serum level of anti-PLA2R antibodies was measured by enzyme-linked immunosorbent assay. Biochemical parameters were estimated initially and at follow-up. RESULTS: Anti-PLA2R antibodies were detected in 52.1% and 27.8% of patients with primary and secondary MN, respectively. Forty-eight patients with primary MN were grouped based on presence or absence of anti-PLA2R antibodies. Proteinuria was more severe in anti-PLA2R-positive patients than in anti-PLA2R-negative patients (urine protein/creatinine ratio 7.922 ± 3.985 g/g vs. 4.318 ± 3.304 g/g, P = 0.001), and anti-PLA2R antibody level was positively correlated with proteinuria. The incidence of chronic kidney disease stage ≥ 3 was higher in anti-PLA2R-positive patients compared with anti-PLA2R-negative patients (P = 0.004). The probabilities of spontaneous remission were higher in anti-PLA2R-negative patients compared with anti-PLA2R-positive patients (P < 0.001). Multivariate analysis demonstrated that anti-PLA2R antibodies are an independent risk factor for developing chronic kidney disease stage ≥ 3 and for not reaching spontaneous remission. CONCLUSION: Detection of anti-PLA2R antibodies at diagnosis in patients with primary MN can predict prognosis and guide treatment decisions.
Antibodies
;
Diagnosis
;
Enzyme-Linked Immunosorbent Assay
;
Follow-Up Studies
;
Glomerulonephritis, Membranous*
;
Humans
;
Incidence
;
Multivariate Analysis
;
Prognosis
;
Proteinuria
;
Receptors, Phospholipase A2
;
Remission, Spontaneous
;
Renal Insufficiency, Chronic
;
Risk Factors
9.Anti-phospholipase A2 receptor antibody as a prognostic marker in patients with primary membranous nephropathy Volume 37, Issue 3, September 2018, Pages 248–256.
Eun Joo SONG ; Kye Hwa JEONG ; Young Ae YANG ; Jeong Hoon LIM ; Hee Yeon JUNG ; Ji Young CHOI ; Jang Hee CHO ; Chan Duck KIM ; Yong Lim KIM ; Sun Hee PARK
Kidney Research and Clinical Practice 2018;37(4):426-426
In the article, there was an error in Figure 3.
Glomerulonephritis, Membranous*
;
Humans
10.The Experience and Competence of Physicians Who Provide Emergency Health Care at Public Health Sub-Centers on Remote Islands in Korea.
Je Hyun SEO ; Su Jin LEE ; Jeong Hoon HA ; Duck Geun KWON ; Jung Ho KIM ; Jae Hyuk LEE ; Baeg Ju NA ; Yoon Hwa KANG
Journal of Agricultural Medicine & Community Health 2011;36(1):36-46
OBJECTIVES: To investigate the experience and competence of physicians providing emergency medical services at public health sub-centers on remote Korean islands. METHODS: This study enrolled 79 doctors who work at public health sub-centers on remote Korean islands. Data were collected in December 2009 via self-administered e-mail questionnaires. The response rate was 44.3%. RESULTS: Emergent situations occurred at most (58.68%) of the public health sub-centers that were surveyed in December 2009. An average of 1.92 cases required treatment by public health physicians. Only 20.25% of the physicians were specialists in emergency medicine, while the remainder were general practitioners (GPs) without clinical experience as emergency doctors. We also found that the physicians we surveyed had insufficient knowledge of emergency medical care. At some health centers only one doctor was available, and there was no medical team in holiday, although most of the physicians indicated that the ideal number of doctors per center was two or three. In cases of emergency, patients were often sent to the mainland by ship without receiving first-aid treatment. The public health sub-centers lacked the necessary medical equipment to save lives in emergencies and lacked escort systems for emergency patients. CONCLUSIONS: The Korean government should address the importance of providing emergency care in remote areas. Health administrators should provide suitable manpower, medical equipment, guidelines for emergency medicine, and education for public health physicians on remote islands.
Administrative Personnel
;
Delivery of Health Care
;
Electronic Mail
;
Emergencies
;
Emergency Medical Services
;
Emergency Medicine
;
General Practitioners
;
Health Services Accessibility
;
Holidays
;
Humans
;
Islands
;
Korea
;
Mental Competency
;
Public Health
;
Ships
;
Specialization
;
Surveys and Questionnaires