1.The Measurement Method of the Skin Amount to Be Excised in the Upper Blepharoplasty.
Journal of the Korean Society of Aesthetic Plastic Surgery 2001;7(2):87-91
No abstract available.
Blepharoplasty*
;
Skin*
2.Expression of Exon 5 - Deleted Estrogen Receptor mRNA in Human Uterine Leiomyoma and Myometrium.
Chul B PARK ; Won I PARK ; Duck S KO ; Ho J LEE
Korean Journal of Obstetrics and Gynecology 2000;43(4):642-648
OBJECTIVE: There is a large and increasing body of experimental and clinical data supporting the existence of variable estrogen receptors in both normal and neoplastic estrogen target tissue. Recently, exon 5 deleted estrogen receptor(D5-ER) has been identified in many estrogen dependent tumors. The purpose of this study is to assess the relationship between uterine myoma and D5-ER. METHODS: The relative amount of wild type estrogen receptor mRNA and D5-ER mRNA were examined in human myometrium and myoma tissue obtained from 12 myoma patients and 12 control subjects by RT-PCR. The correlation between WT/D5-ER ratio and age was also evaluated. RESULTS: There was no difference in expression of D5-ER mRNA not only between myoma and myometrim of the myoma patients, but also between myometrium of myoma patients and normal subjects. No significant correlation was found between D5-ER expression and age of the subjects in myometrial tissue. However, we could find negative correlation between WT/D5-ER ratio and age in myoma tissue. CONCLUSION: Upon these data, we conclude that D5-ER is a common variant mutation of estrogen receptor, which is not related with development of myoma. However, in myoma tissue, there is possibility that D5-ER may act some role in the growth of tumor.
Animals
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Estrogens*
;
Exons*
;
Female
;
Humans*
;
Leiomyoma*
;
Mice
;
Myoma
;
Myometrium*
;
Receptors, Estrogen
;
RNA, Messenger*
3.Reference(cut-off) values of serum total cholesterol for risk groupof atherosclerosis among normal adults in Korea.
Jong Seok PARK ; Dong Yoon KO ; Kyung Hwan CHO ; Myung Ho HONG ; Soon Duck KIM
Journal of the Korean Academy of Family Medicine 1992;13(2):152-163
No abstract available.
Adult*
;
Atherosclerosis*
;
Cholesterol*
;
Humans
;
Korea*
4.Clinical Analysis of Supracondylar Fracture of The Humerus in Children
Yung Khee CHUNG ; Won Ho CHO ; Jung Soo PARK ; Ik Yull CHANG ; Young Duck KO
The Journal of the Korean Orthopaedic Association 1985;20(4):667-674
130 cases of the suprarcondylar fractures of the humerus in children were analysed. 60 cases were immobilized with plaster splint without closed reduction. 22 cases were closedly reduced and immobilized with plaster splint. 47 cases were closedly reduced and were fixed percutaneously with K-wires. 39 cases were operatively reduced and were fixed with K-wires. The following results were obtained. 1. The average age was 7.9 years, and the male and female ratio was 2.7: 1. 2. The extension type was 96.2% and the flexion type was 3.8%. 3. The left side (64.6%) was more frequently involved. 4. As associated complications, nerve injury (4.6%), vascular injury (2.3%), open fracture (2.3%), and associated fracture (2.3%). were developed. During treatment incomplete ulnar nerve palsy (2.3%), pin tract superficial infection(3.1%), severe cubitus varus deformity(4.6%), severe limitation of elbow motion(11.6%) were also developed. 5. Final results in the Holmberg's 4 Groups according to Mitchell & Adams' criteria showed that the more the displacement of fracture is increased, the more the poor result is also increased. 6. In spite of the selection of the more severe cases for surgery, the results of the operative cases were better than those achieved by closed reduction in the easier cases. 7. In the displaced fractures, immediate open reduction brings the satisfactory results and minimizies the sequellae.
Child
;
Elbow
;
Female
;
Fractures, Open
;
Humans
;
Humerus
;
Male
;
Splints
;
Ulnar Neuropathies
;
Vascular System Injuries
5.Effects of Xenoestrogens on Gene Expression of Cytochrome P450 Genes in in vitro Cultured Mice Spermatogenic Cells.
Ho Joon LEE ; Myo Kyung KIM ; Duck Sung KO ; Kil Soo KIM ; Hee Kyoo KANG ; Dong Hoon KIM
Korean Journal of Fertility and Sterility 2001;28(2):131-140
No abstract available.
Animals
;
Cytochrome P-450 Enzyme System*
;
Cytochromes*
;
Gene Expression*
;
Mice*
6.Mutation at exon 10 of the fibroblast growth factor receptor 3 (FGFR3) in a fetus with thanatophoric dysplasia type I (TDI).
Won Kyu YANG ; Won Il PARK ; Duck Sung KO ; Sun Hee KIM ; Eun Kyung KIM ; Ho Joon LEE
Korean Journal of Obstetrics and Gynecology 1999;42(10):2214-2220
Thanatophoric dysplasia (TD) is a sporadic lethal type of skeletal dysplasia featuring micromelia, decreased thoracic dimension and macrocephaly. To date, several kinds of mutation in fibroblast growth factor receptor 3 (FGFR3) has been identified in TD. We experienced a case of TD type I and underwent sequencing of the exon 7, 10 and the stop codon of FGFR3 to identify the type of mutation. TDI was diagnosed by the prenatal ultrasound at 25 weeks of gestation. The pregnancy was terminated and the diagnosis was confirmed by radiological and histologic examinations. The genomic DNA was extracted and the sequences of the exon 7, 10 and the stop codon of FGFR3 were amplified by PCR. The sequencing was performed for the each PCR products by dideoxyterminator method. The nucleotide transition from G to T was found in the nucleotide 1108, which is a part of the transmembrane domain, exon 10. To date, only one type of mutation (nucleotide 742) in the FGFR3 was identified in TD1 among Asian. This case firstly reveals the mutation of FGFR3 other than mutation at nucleotide 742 in TD1.
Asian Continental Ancestry Group
;
Codon, Terminator
;
Diagnosis
;
DNA
;
Exons*
;
Fibroblast Growth Factors*
;
Fibroblasts*
;
Humans
;
Macrocephaly
;
Polymerase Chain Reaction
;
Pregnancy
;
Receptor, Fibroblast Growth Factor, Type 3*
;
Receptors, Fibroblast Growth Factor*
;
Thanatophoric Dysplasia*
;
Ultrasonography
7.128 Cases of Endoscopic Sphincterotomy (EST).
Duck Yeii CHOI ; Ho Soon CHOI ; Byung Seok CHO ; Woo Seok CHOI ; Jin Hyung AHN ; Byung Su PARK ; Jeong Hee KO
Korean Journal of Gastrointestinal Endoscopy 1994;14(2):190-195
Endoscopic sphincterotomy(EST) is now an established therapeutic procedure for various disorder of the pailla of Vater, the biliary tract, and the pancreas. From November 1992 to September l993, 123 cases of E.S.T were performed in our hospital. The success rate of EST was 97.8%, and choledocholithiasis was the indication for EST in 63. 4% of cases. Among 78 cases of choledocholithiasis, 47 cases were presence of gall bladder with stone (16 cases) or without stone (31 cases), especially 46 cases were assisted with needle type papillotome and 23 cases were assisted with guidewire. EST hae relatively low complications and is the therapy of choice for choledocholithiasis and various diisease of biliary tract. Guidewire assisted stanard papillotome probable reduce the use of needle type papillotome in the difficult cases that EST with pull type papillotome was impossible.
Biliary Tract
;
Choledocholithiasis
;
Needles
;
Pancreas
;
Sphincterotomy, Endoscopic*
;
Urinary Bladder
8.Fallopian Tube Occlusion by Selective Transcatheter Radiofrequency Electrocautery.
Joo Hyeong OH ; Yup YOON ; Young Tae KO ; Duck Ho NAM ; Yong Koo PARK
Journal of the Korean Radiological Society 1998;38(4):623-628
PURPOSE: To access the usefulness of transcatheter radiofrequency(RF) electrocautery as a method ofnonsurgical tubal occlusion. MATERIALS AND METHODS: Using the coaxial technique under fluoroscopic guidance,transvaginal fluoroscopic fallopian tube catheterization was performed in thirteen rabbits. In each rabbit,unilateral tubal ablation was performed using RF electrocautery. A 0.018 inch metallic wire protruding from themicrocatheter tip was used as the source of the RF energy ; the length of the noninsulated part of this wire was10mm and the duration of RF supply was 20 seconds. The contralateral normal fallopian tube and uterus were used asa control. All 13 rabbits were randomly sacrified on two days(group I) or 30 days(group II) after the procedure,and tubal patency and histologic change were evaluated. RESULT: In group I(n=5), significant RF ablation-inducedtissue necrosis of the endosalpinx was found in all five rabbits. In group II(n=8), the fallopian tube wascompletely occluded with tubal wall fibrosis, in all eight rabbits, but there was no tissue damage in adjacentperitoneal organs. For contralateral control tubes, the histologic findings were normal. CONCLUSION: Transcatheter RF electrocautery is thought to be a useful method for tubal occlusion. It is simple, safe, and lessexpensive and might have a role in future female tubal steralization.
Animals
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Catheterization
;
Catheters
;
Electrocoagulation*
;
Fallopian Tubes*
;
Female
;
Fibrosis
;
Humans
;
Necrosis
;
Rabbits
;
Sterilization, Tubal
;
Uterus
9.A Case of Scalp Angiosarcoma.
Jong Gu KIM ; Duck Ho KO ; Nam Hoon KIM ; Chang Hoon JEONG
Journal of the Korean Cleft Palate-Craniofacial Association 2002;3(1):86-88
Angiosarcoma is very rare but highly malignant soft tissue tumor derived from the vascular endothelium. This tumor is most commonly found in the skin and subcutaneous tissues. Angiosarcoma is known to cause early and widespread metastasis leading to a very poor prognosis of less than 24 months. We report a case of angiosarcoma developed in the temporoparietal scalp of a 84-year-old man. The patient was referred for us consultation after failed systemic antibiotic treatment, incision drainage treatment for "cellulitis" by the general physician. We performed excision and biopsy. The histologic finding of the lesion showed that irregular, complex vascular channels in dermis. The tumor cells were positive for Factor VIII-related antigen. The lesion was confirmed as cutaneous angiosarcoma. We recommended a radical surgery and reconstruction followed by adjuvant radiation, but the patient refused. The patient was expired 2 months thereafter because of a massive hemorrhagic pleural effusion by suspicious distant metastasis. Authors reported important aspects of clinical findings, histologic features and therapeutic options of the scalp angiosarcoma.
Aged, 80 and over
;
Biopsy
;
Dermis
;
Drainage
;
Endothelium, Vascular
;
Hemangiosarcoma*
;
Humans
;
Neoplasm Metastasis
;
Pleural Effusion
;
Prognosis
;
Scalp*
;
Skin
;
Subcutaneous Tissue
;
von Willebrand Factor
10.The Regulators of VEGF Expression in Mouse Ovaries.
So Young SHIN ; Ho Jung LEE ; Duck Sung KO ; Hoi Chang LEE ; Won Il PARK
Yonsei Medical Journal 2005;46(5):679-686
The objectives of this study were to explore whether ovarian vascular endothelial growth factor (VEGF) expression in mice can be regulated by IL-6 (interleukin-6), angiotensin II, FSH, and hCG; and to test whether the mouse ovarian VEGF expression can result in angiogenesis. The ICR mice were sacrificed, and their ovaries were recovered. Recovered ovaries were treated with IL-6, angiotensin II, FSH, and hCG separately and incubated for 24 hours in alpha-MEM. Expression of mRNA and protein of VEGF were assessed by RT-PCR and immunohistochemistry. The resulting angiogenesis was evaluated through immunohistochemical analysis for CD34. Treatment of mice ovaries with IL-6, FSH, and hCG resulted in a significant increase of VEGF mRNA, and IL-6 was the most potent inducer of VEGF. IL-6 and FSH resulted in increased neovascularization in the follicular phase of mouse ovaries. In contrast, angiotensin II could not increase VEGF expression or neovascularization. We documented an in vitro increase in VEGF expression by IL-6, FSH, and hCG; and reaffirmed that the proliferative response of murine ovarian endothelial cells paralleled an increase of VEGF expression.
Vascular Endothelial Growth Factor A/analysis/*genetics
;
RNA, Messenger/analysis
;
Ovary/*metabolism
;
Mice, Inbred ICR
;
Mice
;
Interleukin-6/pharmacology
;
Immunohistochemistry
;
Gene Expression Regulation/*drug effects
;
Follicle Stimulating Hormone/pharmacology
;
Female
;
Chorionic Gonadotropin/pharmacology
;
Antigens, CD34/analysis
;
Animals