The trial of acute oral toxicity of the seed of Momordica cochinchinensis in mice showed that LD50 of the seed powder is 92.27g/kg. The result of the study should be considered in the attempt to use the seed of Momordica cochinchinensis as a drug administered orally. While waiting for confirmation, it is necessary to inform in public that taking this seed orally should be avoided
toxicity ; Mouth ; seeds

The preliminary in vitro susceptibilities of clinical isolated helicobacter pylori to chitosan were determined in 2 stages: 1) By testing for inhibitory activity against E.coli and P.aeruginosa, we have determined the suitable form of chitosan producing antibacterial activity was 1.7% transparent chitosan gel solution pH6. 2) The in vitro susceptibilities of 20 clinical H. pylori isolated to 1.7% transparent chitosan gel solution pH6 were determined by an agar dilution technique. The MIC value of chitosan against some H. pylori isolates ranged from 0.85 to 6.8mg/ml.
chitosan ; Helicobacter pylori

Purpose: Use experimental scheme to find some optimal conditions for reaction of acylized N-phtalyl chitosan stage. Material: green clawed shrimp shell. Preparing following modified water-heat method. Divide into 2 stages: Preparation N-phtalyl chitosan and soluble film created agent in the intestine in optimal conditions. Result: Derivative can be used to make a soluble film created agent in the intestine like CAP, HPMCP.
Chitosan ; Drug Compounding

Semi synthesis of a derivative of chitosan from shrimp shell, which is called Acetyl phtanyl chitosan. Material: green clawed shrimp, pure chemical. Preparation according to heat-water therapy including 2 stages; Preparation N-phtalyl chitosan and derivative of chitosan with property "film created substance dissolves intestine". Film have property which not dissolve in water, solution of HCl 0.1N, pH 1.3; but well dissolves in solution of phosphate pH6. This derivative can be used to make the film created substance that dissolved in intestine.
chitosan ; Drug Compounding

I. Introduction of film-coating technique; II. Materials: films, pigments and solvents; III. Equipment: Modified coater, Fluidized-bed coater; IV. Formulating solution: Formulating, Calculating amount of solution; V. Types of film: Protective film, Bowel dissoluble film, longer releasing film; IV. Film coating technique using water instead of organic solvent; VII. Testing quality of film coat: Testing polymer and formula, Testing protective, bowel dissoluble and longer releasing film.
Pharmaceutical Preparations ; Meta-Analysis

To stabilize vitamin B12 in tablets containing Vitamin B1+B6+B12, Kollidon Cl-M was used as stabililizer combining with the dispersion of vitamin B12 in dry state before compression. Applying accelerated stability testing with storage condition of t0 = 570C, RH = 80% in 72 hours, the preliminary results showed that the use of Kollidon CL-M 2% in the formulation can improved effect on the stabilization of vitamin B12.
Vitamins ; Pharmaceutical Preparations ; tablets

Gravimetric precipitation method was applied to determine quantitatively triterpene ester glycosides extracted from: Centella asiatia powder, Centasia tablets, Dissovable Tea containing Centella asiatica and Polygonum multiflorum. This method showed simple and easily applicable. It will be evaluated accuracy and reliability in the further study for using in drug quality control.
Centella ; Dosage Forms ; Plants, Medicinal ; Medicine, Traditional

The study was carried out in periods 1995-1999 and 2000-2003. The list included 199 drugs, in which there was 181 drugs belong to IV- Essential Drug List. From pattern of the disease of Khanh Hoa Rehabilitation Nursing Hospital determined through investigation during period 1995 to 2003 and selected pattern of 2000-2003 as the hospital’s pattern of disease, the researchers selected drugs to build a suitable drug list. The researchers determined 5 major selected criteria and marked them suitable to propose Drug list based on classifying group and subgroup of IV Essential Drug List. From the Drug List, formula for calculating needs and prediction cost of drug in 2004 was proposed. Sum up partially 1st quarter 2004, there was no differences between reality cost and predicted cost of drug
Pharmaceutical Preparations ; Hospitals

To establish an appropriate hospital drug list, the local disease prevalence and the revision of drug treatment in Khanh Hoa Rehabilitation Nursing Hospital, a survey and statistics were taken in 9 years (1995-2003). The disease categories observed in the hospital were contained in 19 chapters of The International Classification of Diseases and Related Health Problems - 10th revision (ICD10). Three chapters associated with high prevalence are chapter VI (Diseases of the nervous system), chapter IX (Diseases of the circulation system), and chapter XIII (Diseases of the musculoskeletal system and connective tissue). Based on the local disease prevalence observed in the hospital, treatment guidelines, management capability and payment ability of patients, the Multi-Attribute Decision Analysis Method (MADAM) was applied to list available drugs used in Khanh Hoa Rehabilitation Nursing Hospital. Five decision evaluation criteria including efficacy, safety, ease of use, cost of drug and origin of drug were weighted and scored for the choice of drugs. The obtained result was a drug list which almost uses and promotes the 4th Essential Drug Concept
Pharmaceutical Preparations ; Therapeutics

Background: Laparoscopicappendectomyisasafeandeffectiveprocedureforacute appendicitis. This surgeryhasashorterdurationofhospitalstayandatrendtowardless postoperative infectious complications. Objectives: To evaluate advantages and disadvantages of laparoscopic appendectomy with one navel trocar. Subjects and method: Subjects included 38 cases diagnosed acute appendicitis in Cho Ray hospital, from October 2006 to September 2007. The subjects treated by laparoscopic appendectomy with one navel trocar. Results: The subjects included were 14 males (36.8%) and 24 females (63.2%). The subjects\ufffd?average age was 28.82 years (ranged from 14-68 years). The average time of abdominal pain was 18.39 hours (ranged from 8 to 24 hours). The average operative time was 28.34 minutes (ranged from 15 to 65 minutes). The average time of hospital stay was 2.9 days (ranged 1 to 5 days). 36/38 patients (94.7%) had appendix\u2019s location in right iliac fossa. There were 68.4% of patients who reexamined at postoperation. Conclusions: Laparoscopic appendectomy with one navel trocar is a useful method for reducing hospital stay, complications and return to normal activity.
Appendectomy/methods ; Appendicitis/surgery ;