Objective To investigate the efficacy of tiapride,vitamin B12 combined with transcranial magnetic stimulation(TMS)in the treatment of children with tic disorder(TD)and the effect on serum S100β protein.Methods A total of 100 children with TD treated in Xiamen Hospital of Traditional Chinese Medicine from September 2021 to September 2023 were selected and divided into observation group and control group according to random number table method,with 50 cases in each group.The control group was treated with tiapride and vitamin B12,and the observation group was treated with tiapride and vitamin B12 combined with TMS.The clinical efficacy,serum S100β protein level,neurological function and adverse reactions of two groups were observed.Results The total effective rate of observation group was significantly higher than that of control group(x2=6.061,P=0.014).After treatment,serum S100β protein levels in both groups were significantly lower than before treatment,and sensory and motor scores were significantly higher than before treatment(P＜0.05).The serum S100β protein level in observation group was significantly lower than that in control group,and sensory and motor scores were significantly higher than those in control group(P＜0.05).There was no significant difference in incidence of adverse reactions between two groups(x2=0.177,P=0.674).Conclusion Tiapride and vitamin B12 combined with TMS have significant efficacy in treatment of TD children,which can reduce the level of serum S100β protein,effectively improve nerve function,and have good safety.

It is believed that the main pathogenesis of attention deficit hyperactivity disorder （ADHD） is the abnormality of the ethereal and corporeal soul that dominate perception， behaviour and sensory functions， that is， the left liver ethereal soul ascending too much while the right lung corporeal soul failing to descend， of which lung corporeal soul restlessness and lung failing to astringe and descend is the core. By analyzing the pathogenesis of attention defects due to “heart-lung-kidney-liver four dimensions circuit failure” and hyperactivity and impulsivity due to “liver-heart-lung chief and deputy disharmony” from the perspective of circular movement and five spirits stored in corresponding viscera theory， respectively， it is believed that the lung corporeal soul plays an important role in the onset of this disease， and further summarized that “the five zang （脏） organs are correlated， and the lungs are the pivot” is the pathogenic characteristics， and “the lung corporeal soul is restless， and the lungs fail to astringe and descend” is the core pathogenesis. It is proposed that deficiencies can be treated with self-made Jingning Formula （静宁方） modification to supplement the lungs， calm the corporeal soul， and nourish the source of yin. For deficiency leading to excess， medicinals of clearing the lung， calming the liver， and dissolving phlegm in addition to Jingning Formula can be used to clear metal and calm corporeal soul， inhibit wood and calm ethereal soul， dissolve phlegm and dispel stasis， so as to establish a differentiation and treatment system of “treating syndromes of the five zang organs and focusing on regulating the lungs”， and then provide theoretical reference for clinical diagnosis and treatment.