Anandamide (N-arachidonoylethanolamide), an arachidonic acid derivative, is an endogenous ligand for cannabinoid receptors, which are m embers of the G protein (Gi)-coupled receptors family. Ananamide is mainly foun d in central nervous system, immune system and uterus etc and mimics most of the effects of (－)Δ9-tetrahydrocannabinoid ［(－)Δ9-THC］, a psyco active derivative of marijuana. Fatty-acid amide hydrolase (FAAH), which is inv olved in hydrolyzing anandamide to arachidonic acid and ethanolamide, may quickl y regulate level of anandamide in vivo.

This study analyzed the average annual growth rate of Youth Science Fund projects and the National Science Fund for Distinguished Young Scholar in 11 colleges and universities.Those projects were funded by the department of life science of National Natural Science Foundation of China (NSFC) in 2001- 2009.The average annual growth rate was calculated by Algebraic average method.The results showed that:① the average annual growth rate of Youth Science Fund project rose or dropped with the rise or drop of average annual growth rate of Science Fund Project.② the rapid growth of Youth Science Fund projects may enhance the ability of colleges and universities to gain National Science Fund for Distinguished Young Scholar.③ the capability of colleges and universities to gain life science project funded by NSFC is not balanced among different regions,and this gap is widening,and ④ to narrow the gap between disciplines,greater effort is needed to train outstanding young scholars.

Objective To investigate the effects of nutritional risk on incidence of pressure ulcer in hospitalized elderly patients,and to provide a basis for medical staff to carry out effective preventive measures.Methods Nutritional Risk Screening 2002 (NRS-2002) and nutrition index were applied in 150 elderly patients in the department of neurology for screening and evaluation of nutritional risk.Then the effect of nutritional risk on incidence of pressure ulcer in elderly patients was analyzed.Results 86 cases with nutritional risk and 64 cases without nutritional risk were found.The incidence of pressure ulcer was 16.67％ and 42.67％ respectively.The comparison was made among hemoglobin,serum albumin,pre-albu-min and total lymphocyte count,the difference was statistically significant between the two groups.The incidence of pressure ulcer in elderly patients with nutritional risk was 6.99 times higher than those without nutritional risk.Conclusions To given nutritional risk screening,active and reasonable nutritional support plan to hospitalized elderly patients can reduce the incidence of pressure ulcer.

BACKGROUND:Bone marrow mesenchymal stem cel s have a close relationship with tumor occurrence and development, which are not only involved in tumor recruitment but impact the biological behavior of tumor cel s. OBJECTIVE:To investigate the effect of bone marrow mesenchymal stem cel s on the biological behavior prostate cancer cel line. METHODS:Human bone marrow mesenchymal stem cel s from healthy adults were col ected and cultured in vitro. Cel morphology and cel markers were observed. Using the Transwel technique, human dermal fibroblasts HDF-a were co-cultured with human prostate carcinoma DU145 cel s in positive control group, wild-type prostate carcinoma DU145 cel s cultured alone in negative control group, and bone marrow mesenchymal stem cel s co-cultured with human prostate carcinoma DU145 cel s in experimental group. Flow cytometry assay was used to detect the cel cycle of prostate carcinoma DU145 cel s, soft agar colony formation assay performed to detect cel proliferative ability, and crystal violet staining used to observe DU145 cel migration at 3 days after culture. RESULTS AND CONCLUSION:Compared with the negative control group, cel proportion at G 2/M+S phase, number of transmembrane cel s and colony counting were significantly decreased in the experimental group. These findings indicate that bone marrow mesenchymal stem cel s may inhibit the proliferation and invasion of prostate carcinoma DU145 cel s by shortening the G 2/M+S phase, thereby providing a new insight into the treatment of human prostate cancer.

[Summary] Endometrial receptivity plays an important role in embryo implantation, and uterine fibroids is the most common benign tumor in reproductive women. In recent years, research has showed that uterine fibroids may have an effect on endometrial receptivity through the change of endometrial morphology and biochemical molecules. From the angle of effects of uterine fibroids on endometrial receptivity, this paper studied infertile patients, which may have a new idea to diagnose and treat infertility caused by uterine fibroids.

0.05). Conclusion: The measurements of molar distal movement on model are smilar to those on cephalometric radiograph.

Objective: To evaluate the effect of a new method to treat early primary crossbite . Methods: 20 cases (2.8～6.5 years old ) with anterior crossbite were treated by bonding appliance combined with protracting mask. Cephalometric radiographs were taken and analyzed before and after treatment. Results: On average,in all the 20 cases the maxilla were moved 2.06 mm forward ,mandibular were turned 2.45?downward and backward ,the anterior crossbite was corrected and the face profile was improved satisfactorily.The treatment was conducted for 1.7 months on average. Conclusion: Using bonding appliance combined with protracting mask to treat early primary crossbite can achieve good effects for young children .

Tianshu (ST 25) is a frequently-used acupoint in acupuncture practice. It is reported that deep acupuncture has a better therapeutic effect than routine depth acupuncture. On the basis of reviewing the available literature,the present paper gives a definition about "deep acupuncture" of Tianshu (ST 25) from the anatomy angle,and makes a summary about its safety. This paper also puts forward a set of operation standards for needling Tianshu (ST 25). Moreover,the authors of the present paper also make a systematic analysis on the factors affecting the safety from the punctured depth,the diameter of the acupuncture needle and the operation technique. These methods and standards have an important significance in guiding clinical practice of acu-puncture.

BACKGROUND: Interactive metronome (IM), also known as millisecond rhythm feedback, is a rehabilitative treatment technology supported by neural plasticity theory. Cerebral immediate feedback measured in milliseconds is helpful for understanding neurocognitive mechanisms. OBJECTIVE: To overview the progress of IM applied in the rehabilitation of central nervous system. METHODS: The first author retrieved CNKI (2001-2016), Medline (1989-2016) and Imedpub (2015-2017) databases using the keywords of millisecond rhythm feedback, cognition, motor behavior in English and Chinese, respectively. Data such as theoretical researches on cerebral timing function, the mechanism underlying IM affecting cerebral timing function, and IM operation skills and application were evaluated. RESULTS AND CONCLUSION: A total of 26 eligible articles were enrolled. IM is an objective assessment and training tool that improves neural synchronization and function. IM can accelerate the speed and the efficiency of processing information of white matter tracts, and enhance the function of attention control system in order to improve the disorder of the cerebral timing. IM achieves satisfactory outcomes in the treatment of learning disabilities in children, cognitive impairment after brain injury and cerebral stroke with hemiplegia in adults. Based on the traditional rehabilitative training in the central nervous system, IM addresses critical brain timing skills, which is a promising technology in the future rehabilitation of the central nervous system.