1.The investigation and analysis of medical postgraduates' ! honesty education
Chinese Journal of Medical Education Research 2016;15(11):1110-1114
Objective To understand the current situation of medical postgraduates'!honesty edu-cation, find the weak point and explore new ways of the honesty education. Methods The honesty educa-tion survey questionnaire was designed and conducted to the postgraduates of Grade 2014 in Peking University Health Science Center. The research contents included the basic information of postgraduates, honesty cognition, clean and self-discipline, honesty education, the recommendation of honesty education and the application of honesty education carrier. 1 038 questionnaires of a total of 1 142 questionnaires were recovered and the recovery rate was 90.9%. EPIData3.0 software was used for double entry and database establishment, and SPSS 19.0 software for statistical treatment. Results 82.3% (854) of the postgraduates recognized the work of clean government, but only 62.1% (644) of the postgraduates concerned about it. 78.3% (813) of the postgraduates expressed hatred for the dishonest behavior and hoped to eliminate it. 77.6%(806) postgraduates often paid attention to honest education content which was pushed by the new media. 16.5% (171) postgraduates thought that the new media was very important to the honest cognition. Conclusions We should pay more attention to medical postgraduates'!honesty education, find its weak points according to the investigation and make full use of the network and new media. And at the same time we should combine the actual environment to establish a hierarchy of honesty education system, and carry out honesty education through total environment which contains the school administrators, instructors/head teachers and tutors.
2.On Grass Creates of our Army Medical Morals In The Land Revolution War
Chinese Medical Ethics 1995;0(02):-
Our army medical morals was engendered and developed along with our army medical treatment work.This text is tight and tight hold the "a thought","twice important history affairs","two standard points"and "a slogan",tally up developments experience of the Land Revolution,expatiated process and the basically composition of the mode.
3.Application of thymalfasin in non-operative treatment of cervical cancer
Chinese Journal of Primary Medicine and Pharmacy 2017;24(14):2099-2102
Objective To observe the effect of thymalfasin on non-operative treatment of cervical cancer.Methods Seventy-eight patients with advanced cervical cancer were divided into two groups according to the digital table,each group in 39 cases.The two groups were treated with concurrent chemoradiotherapy.The observation group was given 1.6 mg of thymalfasin subcutaneously each Monday to Friday.While the control group received no additional treatment.And then the two groups were compared in terms of curative effects,adverse reactions,immune states and cellular immune functions.Results The results showed that the differences of curative effects[there were 23 patients in the control group,as compared with 31 patients in the observation group,achieved a complete response(CR),x2=3.852,P<0.05],adverse reactions(grade Ⅲ or Ⅳ radiation-induced enteritis occurred in 4 patients in the observation group,and 12 patients in the control group,x2=5.032,P<0.05;Grade Ⅲ or Ⅳ leukopenia occurred in 16 patients in the observation group,and 25 patients in the control group,x2=4.165,P<0.05;Grade Ⅲ or Ⅳ nausea,vomit occurred in 6 patients in the observation group,and 14 patients in the control group,x2=4.303,P<0.05),immune states and cellular immune functions between the two groups were significant[the counts of CD+3(t=9.236,P<0.05),CD+4(t=7.445,P<0.05),CD+4/CD+8(t=7.445,P<0.05) and NK(t=9.256,P<0.05)]were significantly higher in the observation group after treatment.Conclusion In the treatment of advanced cervical cancer,concurrent chemoradiotherapy combined with thymalfasin can improve the curative effect,reduce the side effects,improve the quality of life and enhance the immunity.
5.Bioinformatic analysis of streptococcus mutans thrS gene and construction of homologous recombinant plasmids
Xiaodi LIU ; Jin DUAN ; Lihong GUO
Chinese Journal of Tissue Engineering Research 2010;14(7):1231-1234
BACKGROUND: Streptococcus mutans (S. mutans) is generally considered to be the principal aetiological agent for dental caries, thrS gene may relate to the virulence of S. mutans involved in the adherence, acidogenicity and acidodurance.OBJECTIVE: To investigate the conservation status of the thrS gene of S. mutans and to construct the homologous recombinant plasmid.METHODS: Southern Blot was used to analyze the distdbuUon of thrS gene in S. mutans. The upstream and downstream sequences of thrS gene were cloned respectively into multiple cloning sites of suicide plasmid pFW5 to construct the recombinant plasmid,RESULTS AND CONCLUSION: The thrS gene was conserved in 6 strains of S. mutans in this test. By PCR analysis and enzyme digesting, it was confirmed that S. mutans thrS gene homologous recombinant plasmid was successfully constructed,which can be used in future research of construction of thrS -negative mutans of S. mutans strain UA159.
6.Research advances in relationship between methyl-CpG binding domain proteins and the repression of tumor repressor genes
Lingling GUO ; Fengying DUAN ; Xiaohua QIU
Cancer Research and Clinic 2008;20(3):211-213
Many genetic events have been described to be involved in the development of tumor,but a lot of recent researches proved that epigenic events also played an important role in it.DNA methylation is one of the common modification of epigenic events,the binding of methyl-CpG binding domain proteins has been shown to lead to transcriptional repression of many tumor repressor genes.
7.Influencing factors for pediatric nurses' reporting of adverse events
Jianjun CHEN ; Lin DUAN ; Guo YU
Chinese Journal of Practical Nursing 2010;26(23):54-56
Objective To identify the influencing factors for pediatric nursese' reporting of adverse events at 3A hospitals in Beijing. Methods Adopting the random sampling of ten 3A hospitals with pediatric wards in Beijing and conducting an questionnaire survey of some nurses in those hospitals. Results The possibility of adverse events reporting increased with the awareness of adverse events which was related with their severity. Except for title, educational background, length of service, position and past experiences were not associated with the barriers. The major perceived barrier was fear of colleague relationship brokenup and some other undesirable consequence. Conclusions Better training of awareness of adverse events and changes of the punitive culture by the roots as well as some regulation or policy were the major solutions to improve incident reporting.
8.Effect of transurethral holmium YAG laser in treatment of bladder calculi
Guo BAO ; Zonghao DUAN ; Hongshuang ZHANG
Chinese Journal of Primary Medicine and Pharmacy 2012;19(5):687-688
Objective To investigate the effect of transurethral holmium YAG laser in treatment of bladder calculi.Methods F5 laser fiber in the holmium YAG laser was used to treat 40 patients with bladder calculi.Then the effect was observed.Results All 40 cases were successfully done by the operation time range from 15 to 120 minutes.There were no major complications,such as TRUS,bladder rupture or major bleeding.There was no residue stone.Conclusion F5 laser fiber in the holmium YAG laser treatment could be protected by the transurethral scope.It was safe,effective and has shorter operation time in treatment of bladder calculi.
9.Targeting the IL-6/STAT3 signaling pathway in cancer treatment
Yuqi GUO ; Duan ZHENFENG ; Zhan ZHANG
Journal of International Oncology 2011;38(6):427-429
Interleukin-6(IL-6)is associated with cancer staging, survival, apoptosis and the sensitivity to chemotherapeutic drugs, and it is overexpressed in the cancer tissue and serum of cancer patient.IL-6 Can regulate proliferation and differentiation of cancer cells through IL-6/STAT3 signaling pathway. Therefore, blocking IL-6/STAT3 signaling pathway has potential therapeutic implications for cancer.
10.Application of mentor-mentee two-way evaluation in the academic ethics trainings for post graduate students
Lingling GUO ; Liping DUAN ; Jinzhong JIA
Chinese Journal of Medical Science Research Management 2017;30(1):31-34,55
Academic ethics is closely related to the construction of the world class disciplines,the academic ethics of university mentors and their graduate students are especially important to the development of disciplines and Universities.This article was based on a survey which used two-way evaluation conducted at Peking University Health Science Center,investigated the cognition,current status,misconduct and possible causes,as well as related trainings of academic ethics between mentors and mentees,furthermore,this article also analyzed the application of mentor-mentee two-way evaluation in the academic ethics trainings for post graduate students.