1.The investigation and analysis of medical postgraduates' ! honesty education
Chinese Journal of Medical Education Research 2016;15(11):1110-1114
Objective To understand the current situation of medical postgraduates'!honesty edu-cation, find the weak point and explore new ways of the honesty education. Methods The honesty educa-tion survey questionnaire was designed and conducted to the postgraduates of Grade 2014 in Peking University Health Science Center. The research contents included the basic information of postgraduates, honesty cognition, clean and self-discipline, honesty education, the recommendation of honesty education and the application of honesty education carrier. 1 038 questionnaires of a total of 1 142 questionnaires were recovered and the recovery rate was 90.9%. EPIData3.0 software was used for double entry and database establishment, and SPSS 19.0 software for statistical treatment. Results 82.3% (854) of the postgraduates recognized the work of clean government, but only 62.1% (644) of the postgraduates concerned about it. 78.3% (813) of the postgraduates expressed hatred for the dishonest behavior and hoped to eliminate it. 77.6%(806) postgraduates often paid attention to honest education content which was pushed by the new media. 16.5% (171) postgraduates thought that the new media was very important to the honest cognition. Conclusions We should pay more attention to medical postgraduates'!honesty education, find its weak points according to the investigation and make full use of the network and new media. And at the same time we should combine the actual environment to establish a hierarchy of honesty education system, and carry out honesty education through total environment which contains the school administrators, instructors/head teachers and tutors.
2.On Grass Creates of our Army Medical Morals In The Land Revolution War
Chinese Medical Ethics 1995;0(02):-
Our army medical morals was engendered and developed along with our army medical treatment work.This text is tight and tight hold the "a thought","twice important history affairs","two standard points"and "a slogan",tally up developments experience of the Land Revolution,expatiated process and the basically composition of the mode.
3.Application of thymalfasin in non-operative treatment of cervical cancer
Chinese Journal of Primary Medicine and Pharmacy 2017;24(14):2099-2102
Objective To observe the effect of thymalfasin on non-operative treatment of cervical cancer.Methods Seventy-eight patients with advanced cervical cancer were divided into two groups according to the digital table,each group in 39 cases.The two groups were treated with concurrent chemoradiotherapy.The observation group was given 1.6 mg of thymalfasin subcutaneously each Monday to Friday.While the control group received no additional treatment.And then the two groups were compared in terms of curative effects,adverse reactions,immune states and cellular immune functions.Results The results showed that the differences of curative effects[there were 23 patients in the control group,as compared with 31 patients in the observation group,achieved a complete response(CR),x2=3.852,P<0.05],adverse reactions(grade Ⅲ or Ⅳ radiation-induced enteritis occurred in 4 patients in the observation group,and 12 patients in the control group,x2=5.032,P<0.05;Grade Ⅲ or Ⅳ leukopenia occurred in 16 patients in the observation group,and 25 patients in the control group,x2=4.165,P<0.05;Grade Ⅲ or Ⅳ nausea,vomit occurred in 6 patients in the observation group,and 14 patients in the control group,x2=4.303,P<0.05),immune states and cellular immune functions between the two groups were significant[the counts of CD+3(t=9.236,P<0.05),CD+4(t=7.445,P<0.05),CD+4/CD+8(t=7.445,P<0.05) and NK(t=9.256,P<0.05)]were significantly higher in the observation group after treatment.Conclusion In the treatment of advanced cervical cancer,concurrent chemoradiotherapy combined with thymalfasin can improve the curative effect,reduce the side effects,improve the quality of life and enhance the immunity.
5.Targeting the IL-6/STAT3 signaling pathway in cancer treatment
Yuqi GUO ; Duan ZHENFENG ; Zhan ZHANG
Journal of International Oncology 2011;38(6):427-429
Interleukin-6(IL-6)is associated with cancer staging, survival, apoptosis and the sensitivity to chemotherapeutic drugs, and it is overexpressed in the cancer tissue and serum of cancer patient.IL-6 Can regulate proliferation and differentiation of cancer cells through IL-6/STAT3 signaling pathway. Therefore, blocking IL-6/STAT3 signaling pathway has potential therapeutic implications for cancer.
6.In vitro culture and phenotype analysis of monocyte-derived dendritic cell from peripheral blood of patients with oral carcinoma
Yuqin DUAN ; Lijun CHENG ; Lantao GUO
Journal of Practical Stomatology 2000;0(06):-
Objective: To compare the phenotype of induced dendritic cell (DC) derived from peripheral blood of the healthy individuals and the patients with oral carcinoma. Methods:15 patients with oral carcinomal at stages II or above were assigned to study group and 15 cases of healthy volunteers were assigned to control group. Leukocyte were isolated by density centrifugation. Adherent fractions were incubated in present of GM-CSF,IL-4 and TNF-? for 7 days in vitro. The morphological change of the cultured cells was observed by light microscopy and electronic microscopy. The phenotype expressions of CD83,CD1a,CD86, CD80, HLA-DR were analysized by flow cytometry. Results:Typical DCs were obtained from two groups after 7 days culture. The expression rate of CD83,CD1a on DC from healthy volunteers was significantly higher than that from patients (P0.05). Conclusion:DC derived from oral cancer patient' s peripheral blood monocyte might be more matured and is a good cell model for further immunotherapy and research.
7.Detection of Serum and Urinary TGF-?_1 in Patients with Primary Chronic Glomerulonephropathy and Its Clinical Significance
Hong GUO ; Linying CAO ; Jian DUAN
Journal of Chinese Physician 2001;0(02):-
Objective To explore change and significance of serum and urinary transforming growth factor-? 1(TGF-? 1)in the patients with primary chronic glomerulonephropathy (PCG). Methods 65 patients with PCG were divided into four groups according to the degree of renal function damage: normal renal function,renal compensatory,renal decompensatory and renal function failure groups. Levels of serum and urinary TGF-? 1 were determined with ELISA, and the levels of urinary protein and renal function were examined as well. Results Levels of serum and urinary TGF-? 1 in patients with PCG were singificantly higher than those in control, and the levels of serum and urinary TGF-? 1 among four groups were significantly different. The TGF-? 1 level of urinary was associated with the degree of renal function damage(r=0 28,P
8.Perspectives on antibacterial activities of traditional Chinese medicine and its potential mechanisms
Sai YANG ; Qiao GUO ; Kangmin DUAN
Chinese Journal of Biochemical Pharmaceutics 2016;36(4):15-19
The discovery and use of antibiotics is one of the most important breakthroughs in medical history.However, the uprising and spread of the drug-resistance bacterial pathogens have posed a great threat on human health once again.There is an urgent need to develop new antibiotics.Traditional Chinese medicine contains a large volume of bioactive substances suited for novel antibiotic development.However, clinical use of antibiotics of Chinese medicine originis are very rare despite the fact that Chinese medicine has been used for infectious diseases for many years.In this paper, we propose a new mechanism of action for Chinese medicine in treating infectious diseases based on our experimental data.Unlike conventional antibiotics which kill pathogens or inhibit their growth, the traditional Chinese medicine probably function through repressing bacterial pathogenicity.That is, they are actually “antipathogenic drugs”.There are several advantages these antipathogenic drugs possess over traditional antibiotics, including that pathogens are less likely to develop resistance and the drugs have less effect on normal members of the human microbe.
9.Research advance of the timing of renal replacement therapy among people with acute kidney injury
Dongchen GUO ; Ang LI ; Meili DUAN
Chinese Critical Care Medicine 2016;28(3):285-288
Acute kidney injury (AKI) is one of the most common serious complications in critically ill patients, and it is an independent risk factor for death. In recent years, renal replacement therapy (RRT) has become one of the routine treatments for AKI patients, however there is no accepted consensus on the optimal timing of RRT over the world. This paper reviewed the clinical studies carried out by researchers in the field of critical care and nephrology, thereby summarized and analyzed the related parameters of the optimal time to carry out, with the exception of previously acknowledged classic RRT indications such as hyperkalemia, severe metabolic acidosis, volume overload and so on. The feasible parameters such as serum creatinine (SCr), blood urea nitrogen (BUN), urine volume, the time admitted in the intensive care unit (ICU) and several standards distinguished AKI stages are discussed in order to find out the cutoff points of those parameters which were best for the patients' outcome, and to provide guidance of decision making for the optimal timing of RRT for AKI patients.
10.Relations Between Regional Cerebral Oxygen Saturation During Cardiac Surgery and Postoperative Cognitive Dysfunction
Duan YI ; Xiangyang GUO ; Qing ZHENG
Chinese Journal of Minimally Invasive Surgery 2016;(1):81-83
[Summary] Regional cerebral oxygen saturation ( rSO2 ) can be used to monitor the changes of cerebral oxygen demand and supply, and postoperative cognitive dysfunction ( POCD ) is a relatively common adverse effect following cardiac surgery. The intraoperative rSO2 decrease may associate with the incidence of POCD. Real-time intraoperative monitoring of rSO2 and necessary interventions performed to correct cerebral rSO2 desaturation may reduce the incidence of POCD of cardiac surgery.