Based on the investigation and analysis of the current situation for hearing aid fitting, some analysis results and suggestions for the development of the industry are presented, including manufacturer, association for medical devices industry and supervision division.
Health Care Sector ; Hearing Aids ; Prosthesis Fitting ; methods

By analysis on the risk management regulations and the situation of medical device after the product on the market, information list of problems and risk analysis process of the production and after-production were described, simultaneously, the suggestions were put forward to risk management after the product on the market, with the aim of providing reference for manufacturers and administrators.
Equipment Safety ; Product Surveillance, Postmarketing ; Risk Management

Objective To investigate the choice of treatment of tubal pregnancy.Methods 128 patients with tubal pregnancy were randomly divided into 43 patients of drug group,42 cases of laparoscopy group,43 cases laparotomy group.The differences of pregnancy status,time to pregnancy,tubal smooth the situation,length of stay,discharge of blood β-HCG were compared.Results Lapamscopic surgery therapy whose intrauterine pregnancy rate reached 80.9%,one year intrauterine pregnancy rate was up to 66.7%,tubal flow rate was 78.6%,and the pregnancy and discharge time was significantly shorter,and the level of β-HCG decresaed when they would go out hospital.Conclusion Laparoscopic surgery therapy had small trauma,better pregnancy rate,low ectopic pregnancy rate,better tubal patency rate,and it could improve fertility,and make discharging quickly,and was an effective treatment for patients with tubal pregnancy.

ObjectiveTo investigate the influence of atorvastatin on C-reactive protein (CRP) level and clinical prognosis for chronic cardiac insufficiency combined with paroxysmal atrial fibrillation patients.Methods One hundred and eight-six chronic cardiac insufficiency combined with paroxysmal atrial fibrillation patients were divided into observation group(93 cases) and control group (93 cases) by random number table.The control group was given conventional treatment such as cardiotonic and diuretic,while the observation group was given atorvastatin 20 mg one time/night for 1 year on the basis of conventional treatment.Before and after treatment,lipid,left atrial diameter,left ventricular ejection fraction (LVEF),CRP and clinical outcome were compared.Results Lipid levels of the control group were not significantly different before and after treatment(P ＞ 0.05 ).In observation group,the levels of total cholesterol (TC),low density lipoprotein-cholesterol (LDL-C) and highdensity lipoprotein-cholesterol(HDL-C) after treatment were improved compared with those before treatment [ (4.1 ± 0.6) mmol/L vs.(4.8 ± 0.6) mmol/L,(2.7 ±0.3) mmol/L vs. (3.5 ±0.5) mmol/L,(1.0 ±0.1) mmol/L vs. (0.9 ±0.1) mmol/L,P ＜0.05].After treatment,the levels of TC,LDL-C and HDL-C in observation group were improved compared with those in control group (P＜ 0.05 ).There was no significant difference in left atrial diameter and LVEF before and after treatment in two groups.The levels of CRP before and 1 month and 6 months after treatment were ( 15.2 ±3.8),(12.1 ±2.7),(9.9 ±2.8) mg/L in observation group,and (15.0 ±3.8),(14.0 ±2.9),(13.7 ±2.8)mg/L in control group,and there were significant differences between two groups 1 month and 6 months after treatment(P ＜ 0.05).The incidences of atrial fibrillation recurrence and conversion for persistent or permanent atrial fibrillation in observation group were significantly lower than those in control group [6.5％ (6/93) vs.21.5％ (20/93),6.5％ (6/93) vs.19.4％ ( 18/93 ),P ＜ 0.05 ].ConclusionAtorvastatin can reduce CRP level of chronic cardiac insufficiency combined with paroxysmal atrial fibrillation patients,and reduce and delay recurrence and progress of paroxysmal atrial fibrillation.

Objective To investigate the effect of the application of quality control theory in nursing of patients with acute cerebrovascular disease undergoing interventional therapy.Methods 64 cases of patients with acute cerebrovascular disease from November 2009 to October 2011 in our hospital undergoing interventional therapy were chosen as the research object.They were randomly divided into the control group and the observation group with 32 cases in each group.The control group was given routine care,while the observation group was given nursing intervention under the instruction of quality control theory.The hospital stay,complication rates,satisfaction and SAS score,SDS score between the two groups of patients were compared.Results The length of stay,complication rate,satisfaction degree,SAS scores and SDS scores after the intervention in the observation group were significantly better than those of the control group.Conclusions Application of the theory of quality control in nursing of patients with acute cerebrovascular disease has a better effect,demonstrating an evident advantage in reducing complications and improving patients' mental state.

Objective To investigate the inhibitory effect of celecoxib on non-small cell lung cancer in vitro and the role of survivin.Methods The inhibitory effect of celecoxib was detected by MTT.Flow cytometry and electron microscope were used for evaluation of apoptosis.The expression of survivin was detected by RT-PCR and Western blot.Results ①Celecoxib inhibited cell survives in a time-dependent and concentration-depended manner,and the effect of celecoxib was more significant in NCI-H520 than in A549.②Celecoxib caused apoptosis in concentration-depended manner.3.Celecoxib decreased the expression of survivin.Conclusion The decrease of the expression of survivin may play a critical role in the apoptosis of NSLLC in vitro induced by celecoxib.

Objective:To observe the effect of periodontal initial therapy on the serum level of lipid in the patients with both periodontitis and hyperlipidemia.Methods:Twenty patients with both hyperlipidemia and moderate to severe chronic periodontitis were enrolled in this study.Periodontal parameters [plaque index(PLI),bleeding on probing(BOP),bleeding index(BI),probing depth(PD) and attachment level(AL)] were evaluated prior to and 3 months after periodontal initial therapy.Simultaneously,the patients' serum levels of total cholesterol,triglyceride,high-lipoprotein cholesterol,low-lipoprotein cholesterol were also measured.Results:(1) Three months after periodontal therapy,the periodontal infection and inflammation in patients reduced comparing with baseline.The PD,PLI,BI,and BOP decreased significantly(the PD,PLI,BI,and BOP reduced from 3.98?0.12 to 2.39?0.13,1.23?0.10 to 0.84?0.08,2.63?0.14 to 1.48?0.08 and 94.26?1.84 to 33.57?2.06,respectively;P

Chimeric antigen receptor (CAR) T cell shows its significant therapeutic effect in part of leukemia and lymphomas, which indicates that transgenic adoptive cellular immunotherapy may be one of the breakthroughs in treatment of solid tumors and blood diseases. The functional inhibition of CAR endogenous cells in the tumor microenvironment , molecular biology function of molecules, difficulties of CAR T cells in clinical application and the solutions , how to improve the clinical efficacy and to reduce toxic side effects for future cancer immunotherapy in clinic are reviewed in this paper.

Objective To investigate the clinical effects of artificial tear gel combined with diclofenac sodium in the treatment with xerophthalmia.Methods 110 patients with xerophthalmia were chosen as study subjects,and they were divided into research group(artificial tear gel + diclofenac sodium)and control group(artificial tear gel).BUT,FS,SIT,mental statue,symptom score and clinical effects after 20 days were compared between the two groups.Results The total effective rate of research group was 90.48%,which of the control group was 75.24%,the difference was statistically significant(x2=8.582,P<0.05).The FS[(0.87±0.15)points vs.(1.53±0.84)points]of the research group was lower than that of the control group after treatment,and the BUT[(9.86±1.13)s vs.(5.71±1.27)s],SIT[(6.85±1.59)mm/5min vs.(4.38±2.07)mm/5min]of the research group were higher than those of the control group,the differences were statistically significant(t=7.926,21.352,9.697,all P<0.05).After treatment,the symptom score of the research group was lower than that of the control group[(8.39±3.24)points vs.(12.85±3.42)points],the difference was statistically significant(t=9.701,P<0.05).The SDS score [(37.16±5.63)points vs.(56.49±6.14)points]and SAS score[(35.24±5.38)points vs.(54.30±6.42)points]of the research group were lower than those of the control group after treatment,and the differences were statistically significant(t=23.777,23.317,all P<0.05).Conclusion Artificial tear gel combined with diclofenac sodium can rapidly improve the clinical symptom of xerophthlmia and treatment effect.

Muscle-specific microRNAs (myomiRs) are a class of small endogenous non-coding RNAs that expressed specifically in the muscle tissue.By negatively regulating related gene expression at posttranslational level,they participate in a variety of biological processes and affects the occurrence and development of diseases.The occurrence and development of muscle-related diseases,such as chronic obstructive pneumonia disease,hypertrophic cardiomyopathy and so on,induce the expression changes of myomiRs and downstream target genes.The effects of myomiRs on the muscle contraction will affect the development of the disease.This paper will review the biological effects of common myomiRs,such as miR-1,miR-133,miR-206,miR-208 and miR-499 in muscle contraction and relaxation,including striated and non-striated muscle.Better understanding of the effects of myomiRs on the biological effects of muscle contraction and relaxation will provide a new idea for the treatment of muscle-related diseases.