TRP(transient receptor potential) ion channel is a kind of membrane proteins which are widespreadly present in various cells,which is used to identify various mixed flavor and warm,heat,cold,and other temperature.Originally cloned as a proatate-specific protein.TRPM8 is now best known as a cold-and menthol-activated channel implicated in thermosensation.We provide a brief review of current knowledge concerning the biophysical properties,gating mechanisms,pharmacology and(patho)physiology of this TRP channel.

The more and more application of assistive technology in special education not only makes education placement of student with disability diversification, but also provides more opportunity for them to participate in instruction. However, there are some problems remained, such as the application is still in low level, the lack of the systematic evaluation for their efficacy and so on. It is necessary to pay more attention on the assistive technology, cultivate more specialists and other related persons on assistive technology, create assistive technology system, and perfect the service system.

The blood vessels of the adrenal gland of 28 fetuses and newborns were studied in this work. Three methods, the injection replication of the microvasculature for scanning electron microscopy, the injection of ink for light microscope and lead latex injection for gross anatomy, have been used. The superior, middle and inferior arteries of the adrenal gland originate from the inferior phrenic artery, abdominal aorta and renal artery respectively. They branch into fin- er arteries when they reach the surface of the gland and run through the capsule of the gland. The finer arteries divide into branches beneath the capsula of the gland. Some of the ultimate branches divide into capillaries and form the subcapsular plexus proper. Others enter directly into the adrenal cortex and medulla separately. They are named the cortical arteries and medullary arteries. Looped cortical arteries run into the cortex from subcapsular plexus, and return to the subcapsular plexus and supply it with blood. We call them the "V" type arteries. The subcapsular plexus gives off numerous capillaries that form the adult cortical capillary plexus which supplies, in turn, the fetal cortex capillaries with blood. The cortical arteries give off the capillaries to supply blood to the fetal cortex. These two kinds of the capillaries form the fetal cortical capillary plexus. In the middle of the fetal cortex the capillaries converge into small veins which run centripetally. Some of them form the first order branch of the central vein. Others break up into the capillaries near the central region. These capillaries converge into the small venous channels which drain into the central vein. This form of vessels is named the "portal vessels". Medullary cells migrating in the cortex are supplied with blood by the medullary arteries proper. The small veins converge gradually to form a treelike pattern and finally drain into the central vein which emerges as the adrenal vein on the anterior surface of the gland. The right adrenal vein drains into the vena cava inferior and the left one into the renal vein. Adrenal arteries are accompanied by the corresponding veins. The superior adrenal vein drains toward the inferior phrenic vein. The middle adrenal vein drains into the adrenal vein, and the inferior one into the renal vein.

ObjectrueTo evaluate magnetic resonancec ho langiopancreatography (MRCP) in the diagnosis of acute or chronic pancreatitis . MethodsMRCP was undertaken in 30 patients with chronic and 9 with acute pancreatitis. Comparison was m ade with findings at ERCP.ResultsOf 196 segments of biliary-pancreatic duct analyzed, 17 were not seen at MR CP (sensitivity, 91%). Of the segments visualized at MRCP, 14 were incorrect ly characterized (accuracy, 92%). At MRCP, segments not detected or mischara cterized were either normal, slightly dilated, or narrowed. MRCP image quali ty was not interpretable in two cases due to artifacts. ConclusionVery good correlation between ERCP and MRCP findings was demonstrated. MRCP may substitude for ERCP, particularly in pa tients who cannot undergo ERCP or in whom ERCP has been unsuccessful.

OBJECTIVE: To study the clinicopathologic features, immunophenotype, diagnosis and differential diagnosis of Sinonasal teratocarcinosarcoma (SNTCS). METHOD: The clinical findings, morphologic features and immunohistochemical markers in one case of SNTCS were studied, and the relevant literatures were reviewed. RESULT: The Tumor tissue is composed of three layers, with mature and immature squamous epithelium nests, neural epithelial cells and olfactory neuroblastoma-like cells derived of ectoderm; Sarcomatoid components and bone tissue derived of mesoderm; The glandular and tubular structures part of which is adenocarcinoma and respiratory epithelium derived of endoderm; The fetal clear cell squamous epithelium is typical. In addition, diffuse large cytoplasm-with high light and cytoplasm with dark light has no obviously boundery. Immunohistochemical staining showed immune markers of different germ layers corresponding, squamous epithelium, glandular epithelium and respiratory epithelium were positive for CK and EMA, neural epithelial cells and olfactory neuroblastoma-like cells were positive for S-100, NSE and Syn, sarcomatoid area was positive for Vim, light dye area was positive for Vim, CD99 and CK, dark area was positive for NSE and GFAP. CONCLUSION SNTCS is a rare malignant tumor with the features of teratoma and carcinosarcoma, its histopathological and immunohistochemical features were typical, should be more drawn and sliced to avoid misdiagnosis and missed diagnosis.
Adenocarcinoma ; Carcinosarcoma ; diagnosis ; immunology ; pathology ; Diagnosis, Differential ; Esthesioneuroblastoma, Olfactory ; diagnosis ; immunology ; pathology ; Humans ; Nasal Cavity ; Nose Neoplasms ; diagnosis ; immunology ; pathology ; Teratoma ; diagnosis ; immunology ; pathology

Acupuncture Therapy ; Adolescent ; Adult ; Female ; Humans ; Lumbosacral Region ; injuries ; Male ; Middle Aged ; Moxibustion ; Sprains and Strains ; therapy ; Young Adult

AIM To observe the effect of sodium orthovanadate on glucose and maltose absorption and to reveal its mechanism. METHODS ① Normal Wistar rats were divided into 6 groups at random, 0 9% NaCl group, acarbose group(30 mg?kg -1 ) and sodium orthovanadate high dose(16 mg?kg -1 ), middle dose (4 mg?kg -1 ) and low dose (1 mg?kg -1 )groups. The values of blood glucose of all the groups were measured with oxidation enzyme method after administration of glucose and maltose. ② The ? glucosidase was abstracted from the upper small intestine and the inhibitory effect of sodium orthovanadate on ? glucosidase was examined. RESULTS ① Sodium orthovanadate could delay the peak values of plasma glucose induced by glucose, with AUC in these groups lower than that in controls, that is (8 42?0 63) mmol?h -1 ?L -1 ( P

Objective To explore the value of serum procalcitonin detection in judging whether severe patients complicate with infection.Methods 188 patients in the intensive care unit (ICU)were collected and divided into the infection and non-infection groups.The serum procalcitonin(PCT),C-reactive protein(CRP),total number of white blood cells(WBC)and neutrophile cell ratio were simultaneously monitored;41 cases in the infection group dynamically monitored PCT and related indicators for continuous 1-6 d and the statistical analysis was conducted.Results The age,PCT and CRP had statistically significant differences between the infection group(112 cases)and non-infection group(76 cases).Except the correlation of PCT and CRP in the infection group showing statistical significance,the comparison of the other indicators had no statistical differences.In the infectors,the PCT value comparison between on 1 d and 2 d in the hospital discharge group(32 cases)and the death group (9 cases)showed P >0.05,the PCT value comparison between on 3-6 d showed P <0.05.Conclusion Serum PCT is an effective indicator to judge whether se-vere infected patient has infection and is significantly superior to the traditional inflammatory indicators.Dynamically monitoring the PCT level in the critical patients has a certain value to judge the control situation of infection.

Objective To explore the imaging features of pediatric splenic primary solitary tumor. Methods The medical imaging appearances of 6 children with splenic primary solitary tumor conifrmed by surgery and pathology from January 2010 to August 2015 were retrospectively studied. The related literatur were reviewed. Results In 6 children, 2 children of cystic lesions, ultrasound showed anechoic mass, CT scan showed low density mass, without change after contrast, pathologically conifrmed as congenital cyst;2 children’s ultrasound showed solid echo, color Doppler ultrasound explored the blood lfow signals, contrast CT showed the lower strength around the splenic parenchyma, pathologically conifrmed as splenic lymphangioma;one child’s unltrasound showed echo mass with rich signals of blood lfow, MRI scans showed T1WI, T2WI and other signals of lumps, with little homogenity after contrast, pathologically conifrmed as splenic hamartoma;one child’s ultrasound cannot distinguish tumor boundaries, contrast CT scan showed concentric filling reinforcement, pathologically confirmed as hemangioma. Conclusion Splenic primary solitary tumor in children is rare. There are no speciifc clinical characteristics. The image ifndings can deifne the locations and help the differential diagnosis. The ifnal diagnosis depends on pathology.