1.Severe liver injury induced by repeated use of hair dye.
Feng-Qin HOU ; Xiao-Hong LIN ; Yan-Yan YU ; Tai-Ling WANG ; Gui-Qiang WANG
Chinese Medical Journal 2009;122(7):875-877
2.A case of levocetirizine-induced liver injury.
Moon Chan JUNG ; Ja Kyung KIM ; Jae Yeon CHO ; Jae Won SONG ; Bohyun LEE ; Ji Won PARK ; Jinwon SEO ; Sung Eun KIM
Clinical and Molecular Hepatology 2016;22(4):495-498
Levocetirizine is a second-generation nonsedative antihistaminic agent that has been demonstrated to be safe and effective for treating allergic disease. There was only one case report of levocetirizine-induced liver toxicity, but a liver biopsy was not performed. In this article, we present the first case of levocetirizine-induced liver injury with histologic findings. A 48-year-old man was hospitalized with jaundice and generalized pruritus that had developed after 2 months of therapy with levocetirizine for prurigo nodularis. Laboratory findings revealed acute hepatitis with cholestasis. A liver biopsy demonstrated portal inflammation and hepatitis with apoptotic hepatocytes. The patient fully recovered 3 weeks after withdrawing levocetirizine. Although levocetirizine is safe and effective, physicians should be aware of its potential hepatotoxicity.
Cetirizine/*adverse effects/therapeutic use
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Chemical and Drug Induced Liver Injury/*diagnosis/pathology
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Histamine H1 Antagonists, Non-Sedating/*adverse effects/therapeutic use
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Humans
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Hypersensitivity/drug therapy
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Jaundice/etiology
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Liver/pathology
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Male
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Middle Aged
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Pruritus/etiology
3.Acute Toxic Hepatitis Caused by an Aloe Vera Preparation in a Young Patient: A Case Report with a Literature Review.
Jeonghun LEE ; Mi Sun LEE ; Kwan Woo NAM
The Korean Journal of Gastroenterology 2014;64(1):54-58
Aloe is one of the leading products used in phytomedicine. Several cases of aloe-induced toxic hepatitis have been reported in recent years. However, its toxicology has not yet been systematically described in the literature. A 21-year-old female patient was admitted to our hospital with acute hepatitis after taking an aloe vera preparation for four weeks. Her history, clinical manifestation, laboratory findings, and histological findings all led to the diagnosis of aloe vera-induced toxic hepatitis. We report herein on a case of acute toxic hepatitis induced by aloe vera.
Adult
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Aged
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Alanine Transaminase/blood
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Alkaline Phosphatase/blood
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Aloe/*chemistry/metabolism
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Drug-Induced Liver Injury/*diagnosis/etiology/pathology
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Female
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Humans
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Liver/pathology
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Male
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Middle Aged
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Plant Extracts/*adverse effects/*chemistry
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Splenomegaly/diagnosis
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Tomography, X-Ray Computed
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Young Adult
4.A case report of alverine-citrate-induced acute hepatitis.
Jee Young HAN ; Jin Woo LEE ; Joon Mee KIM ; Kowoon JOO ; Ung CHON ; Jung Il LEE ; Seok JEONG ; Don Haeng LEE ; Young Soo KIM ; Kyung Sun MIN
The Korean Journal of Hepatology 2010;16(1):75-78
Alverine citrate is one of the most commonly used antispasmodic drugs for patients with irritable bowel syndrome. Alverine-citrate-induced hepatotoxicity is extremely rare, with only a few cases having been reported worldwide. We present a case of a 75-year-old female patient who experienced complicated jaundice and abdominal discomfort after taking alverine citrate. Other causes of hepatitis were ruled out and the results of the liver function test returned to normal after ceasing the drug. This is the first case report in Korea of alverine-citrate-induced hepatotoxicity.
Acute Disease
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Aged
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Citrates/*adverse effects/therapeutic use
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Drug-Induced Liver Injury/*diagnosis/etiology/pathology
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Female
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Humans
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Irritable Bowel Syndrome/drug therapy
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Liver Function Tests
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Parasympatholytics/*adverse effects/therapeutic use
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Propylamines/*adverse effects/therapeutic use
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Tomography, X-Ray Computed
5.The clinical features of drug-induced liver injury observed through liver biopsy: focus on relevancy to autoimmune hepatitis.
Hye Young JU ; Jae Young JANG ; Soung Won JEONG ; Sung Ae WOO ; Min Gyu KONG ; Hee Yoon JANG ; Sae Hwan LEE ; Sang Gyune KIM ; Sang Woo CHA ; Young Seok KIM ; Young Deok CHO ; So Young JIN ; Hong Soo KIM ; Boo Sung KIM
Clinical and Molecular Hepatology 2012;18(2):213-218
BACKGROUND/AIMS: Accurate diagnosis of drug-induced liver injury (DILI) is difficult without considering the possibility of underlying diseases, especially autoimmune hepatitis (AIH). We investigated the clinical patterns in patients with a history of medication, liver-function abnormalities, and in whom liver biopsy was conducted, focusing on accompaniment by AIH. METHODS: The clinical, serologic, and histologic findings of 29 patients were compared and analyzed. The patients were aged 46.2+/-12.8 years (mean+/-SD), and 72.4% of patient were female. The most common symptom and causal drug were jaundice (58.6%) and herbal medications (55.2%), respectively. RESULTS: Aspartate aminotransferase (AST), alanine aminotransferase, total bilirubin, alkaline phosphatase, and gamma-glutamyl transpeptidase levels were 662.2+/-574.8 U/L, 905.4+/-794.9 U/L, 12.9+/-10.8 mg/dL, 195.8+/-123.3 U/L, and 255.3+/-280.8 U/L, respectively. According to serologic and histologic findings, 21 cases were diagnosed with DILI and 8 with AIH. The AIH group exhibited significantly higher AST levels (537.1+/-519.1 vs. 1043.3+/-600.5 U/L), globulin levels (2.7+/-0.4 vs. 3.3+/-0.5 g/dL), and prothrombin time (12.9+/-2.4 vs. 15.2+/-3.9 s; P<0.05). Antinuclear antibody was positive in 7 of 21 cases of DILI and all 8 cases of AIH (P=0.002). The simplified AIH score was 3.7+/-0.9 in the DILI group and 6.5+/-0.9 in the AIH group (P<0.001). CONCLUSIONS: Accurate diagnosis is necessary for patients with a history of medication and visits for liver-function abnormalities; in particular, the possibility of AIH should be considered.
Adult
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Alanine Transaminase/blood
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Antibodies, Antinuclear/blood
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Aspartate Aminotransferases/blood
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Biopsy
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Drug-Induced Liver Injury/*diagnosis/pathology
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Female
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Globulins/analysis
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Hepatitis, Autoimmune/*diagnosis/pathology
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Herbal Medicine
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Humans
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Jaundice/etiology
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Male
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Middle Aged
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Prothrombin Time
6.Acute liver injury induced by the bark of olive in 12 patients.
Chinese Journal of Hepatology 2010;18(2):153-153
Acute Disease
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Adult
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Chemical and Drug Induced Liver Injury
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diagnosis
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drug therapy
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etiology
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pathology
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Drugs, Chinese Herbal
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adverse effects
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isolation & purification
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Female
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Gastritis
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etiology
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Humans
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Liver
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pathology
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Liver Function Tests
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Male
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Middle Aged
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Olea
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chemistry
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Plant Bark
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chemistry
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Protective Agents
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therapeutic use
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Retrospective Studies