In recent years, with the sustained increase of the incidence of diabetes in humans and the wider use of exogenous insulin, the cases of inappropriate use and overdose of insulin is growing, even the cases of suicide and homicide using insulin. Through searching the literature at home and abroad about the mechanism, clinical and case report of poisoning and death caused by insulin intoxication, this paper reviews the mechanism, clinical manifestations, pathological changes, and forensic examination.
Death ; Drug Overdose/diagnosis* ; Homicide ; Humans ; Insulin/poisoning* ; Suicide

OBJECTIVES: To perform retrospective analysis on 20 dead cases related to heroin abuse, and to provide references for the forensic assessment of correlative cases. METHODS: Among 20 dead cases related to heroin abuse, general situation, using method of drug, cause of death and result of forensic examination were analyzed by statistical analysis for summarizing the cause of death and pathologic changes. RESULTS: The dead were mostly young adults, with more male than female. The results of histopathological examinations showed non-specific pathological changes. There were four leading causes of death, including acute poisoning of heroin abuse or leakage （13 cases, 65%）, concurrent diseases caused by heroin abuse （3 cases, 15%）, inspiratory asphyxia caused by taking heroin （2 cases, 10%）, and heroin withdrawal syndrome （2 cases, 10%）. CONCLUSIONS The forensic identification on dead related to heroin abuse must base on the comprehensive autopsy, and combine with the qualitative and quantitative analysis of heroin and its metabolites in death and the case information, as well as the scene investigation.
Adult ; Autopsy ; Cause of Death ; Drug Overdose/diagnosis* ; Female ; Forensic Pathology ; Forensic Toxicology ; Heroin/poisoning* ; Humans ; Male ; Retrospective Studies ; Young Adult

No abstract available.
Acute Disease ; Anticonvulsants/*poisoning ; Diagnosis, Differential ; *Drug Overdose ; Humans ; Male ; Middle Aged ; Phenytoin/*poisoning ; Predictive Value of Tests ; Respiratory Insufficiency/*chemically induced/diagnosis/therapy ; *Suicide, Attempted ; Tomography, X-Ray Computed

diagnosis and intensive treatment are mandatory in order to effectively resolve the situation. The most common etiology for this pathology is cardiogenic, such as left ventricular failure and valvular disease. The one following is noncardiogenic, such as transfusion, infectious pneumonia, inhaled toxins, shock lung in association with trauma. Other forms of pulmonary edema which have not been clearly explained result from pulmonary embolism, drug overdose, after anesthesia, epinephrine overdose, exposure to high altitude, neurogenic, etc. We experienced two cases of pulmonary edema during two jaw surgeries(Le Fort I Osteotomy and BSSRO). These patients were young and physically healthy individuals on preoperative evaluation. Thus we report and discuss the etiology, diagnosis, prognosis, and treatment with journals review.]]>
Altitude ; Anesthesia ; Diagnosis ; Drug Overdose ; Early Diagnosis ; Edema ; Epinephrine ; Humans ; Jaw ; Orthognathic Surgery ; Osteotomy ; Pathology ; Physical and Rehabilitation Medicine ; Pneumonia ; Prognosis ; Pulmonary Edema ; Pulmonary Embolism ; Respiratory Distress Syndrome, Adult ; Sputum ; Thorax