Tujia ethnic medical science is an important sub-discipline of China's ethnic medicine system, which has rooted in major Tujia ethnic area such as Hunan, Hubei, Guizhou and Chongqing. It has its own theory, medication characteristic and experi-ence towards ethnic drugs. Particularly, in medication incompatibility, it has formed the principle of thirteen or fourteen incompatible medicament of traditional Tujia ethnic drugs, which play a certain role in guiding the usage and compatibility of tens of thousands of herbs. Focusing on the incompatibility that is abided by Tujia medical workers, the essay makes a textual study on the origin of herbs and conducts a preliminary study on the theoretical basis of thirteen or fourteen incompatible medicaments in terms of four properties of drugs and toxic and side-effect by reference to the records on nature and flavor and effectiveness, with a view of providing a preference to improve the incompatibility theory of traditional Chinese medicines and new ideas to further studies on the development and application of traditional ethnic drugs.
China ; ethnology ; Drug Incompatibility ; Medicine, Chinese Traditional

To study the interaction of traditional Chinese medicines and Western drugs in the interest of the interaction of Chinese and Western drugs viewing from their own characteristics, pharmacokinetics and pharmacodynamics to provide a scientific basis for rational clinical utilization of drugs. Pharmacological mutual coordination and/or restriction existed between the two kinds of drugs. When they were used in combination, it would increase or decrease adverse reactions, or even toxic reaction. When traditional Chinese drugs were used in combined with Western drugs, it is ought to know the nature and pharmacological effect of various chemical constituents in the compound for the best combination, try to avoid adverse drug interactions for the sake of reaching the goal of high effectiveness, safety and harmlessness.
Drug Incompatibility ; Drug Interactions ; Drugs, Chinese Herbal ; Medicine, Chinese Traditional

OBJECTIVETo study the toxicity changes of different proportions of Radix Adenophora, Radix Glehniae combined with Veratrum nigrum L., thus providing acute toxicity data and investigating whether decoction factors were correlated with toxicity.

METHODSThe uniform design method was used by two factors and seven levels to investigate the toxicity changes in different proportions of Radix Adenophora, Radix Glehniae combined with Veratrum nigrum L. The decoction factors were also investigated.

RESULTSThe compatibility toxicity was affected mainly by Veratrum nigrum L. and the toxicity increased along with increased doses of Veratrum nigrum L. The toxicity of co-decoction was higher than mixed decoction in the same dosage of Radix Glehniae and Veratrum nigrum L. The promotion of the dissolution of the toxic component of Veratrum nigrum L. in co-decoction may be the cause of the higher toxicity.

CONCLUSIONRadix Adenophora and Radix Glehniae combined with Veratrum nigrum L. resulted in higher toxicity, which indicated that the incompatibility between Radix Adenophora, Radix Glehniae, and Veratrum nigrum L. In clinic practice, a prescription contained these drugs should be avoided.

Animals ; Drug Antagonism ; Drug Incompatibility ; Drugs, Chinese Herbal ; administration & dosage ; toxicity ; Female ; Male ; Mice

OBJECTIVETo explore the current application and features of Aconite prescriptions with incompatible herbs in grade A class three hospitals in east China and central China through a clinical study and comparative analysis.

METHODClinical prescriptions containing Aconite with incompatible herbs were collected. Association rules were utilized to analyze the compatible features of these herbs.

RESULTThis analysis found that the frequently used incompatible herba; pairs are Aconiti Lateralis Radix Praeparata-Pinelliae Rhizoma, with the support rate of 44.45%, occupying nearly half of the surveyed prescriptions; Pinelliae Rhizoma is the most frequently used herb in the two areas, with support rate up to 76.24%. Among the top 10 herbal pairs in the support rate, except for Aconiti Lateralis Radix Praeparata and Pinelliae Rhizoma, the top 10 herbs in Central China were mostly for warming the middle jiao and tonifying qi, such as Zingiberis Rhizoma, Atractylodis Macrocephalae Rhizoma and Codonopsis Radix; Whereas those in east China were mostly for activating and nourishing blood, such as Angelicae Sinensis Radix, Chuanxiong Rhizoma, and Salviae Miltiorrhizae Radix et Rhizoma. Among the top 10 herbal pairs in the support rate, except for Aconiti Lateralis Radix Praeparata-Pinelliae Rhizoma, the core herbal pairs applied in central China were mainly for resolving phlegm and warming the middle jiao, such as Pinelliae Rhizoma-Glycyrrhizae Radix et Rhizoma, Pinelliae Rhizoma-Zingiberis Rhizoma; Whereas those in east China were principally for activating blood and tonifying qi, like Atractylodis Macrocephalae Rhizoma and Pinelliae Rhizoma, Angelicae Sinensis Radix and Pinelliae Rhizoma. Among the core herbal groups in the two areas, the most frequently used herbal groups in the two areas are Aconiti Lateralis Radix Praeparata, Glycyrrhizae Radix et Rhizoma and Pinelliae Rhizoma with the support rate of 59.73%, accounting for the highest proportion among all of herbal groups.

CONCLUSIONThere are the combined clinical application of Aconite with incompatible herbs, mostly with Aconiti Lateralis Radix Praeparata-Pinelliae Rhizoma, but with differences in the combined application in east China and central China.

Aconitum ; chemistry ; Drug Incompatibility ; Drug Prescriptions ; Drugs, Chinese Herbal ; chemistry ; pharmacology ; Humans ; Pinellia ; chemistry ; Sophora ; chemistry

Compatibility mechanism study of Chinese herbal compound (CHC) has been one of key contents in Chinese medical research, but the present research methods are not suitable for its own features due to its complexity, which has restricted the process of modernization and intemationalization of Chinese medicine. In this paper, we addressed that the compatibility is closely correlated to their in vivo metabolic processes. The preparation of active small molecules monoclonal antibodies in herbs and testing a variety of effective compositions simultaneously using immunoassay can clarify the in vivo metabolism and mutual interactions of Chinese herbs, which is a new thought of studying the compound compatibility mechanisms.
Antibodies, Monoclonal ; administration & dosage ; Drug Combinations ; Drug Incompatibility ; Drugs, Chinese Herbal ; administration & dosage

The compatible use of Veratrum nigrum with asarum, is one of the eighteen incompatible pairs. To research the toxic regularity of the compatible use of V. nigrum and asarum, this experiment adopted the uniform design combining with acute toxicity test, with the number of died animals as the observation indicator. The results showed that the toxicity came from the common effect of V. nigrum and asarum, and V. nigrum after the compatible use, and V. nigrum made a greater contribution to the toxicity caused by the compatible use. But the toxicity did not absolutely enhance with the increase in use of V. nigrum.
Animals ; Asarum ; toxicity ; Drug Incompatibility ; Female ; Lethal Dose 50 ; Male ; Mice ; Veratrum ; toxicity

OBJECTIVETo evaluate the efficacy of three categorized formulas for tonifying Shen yang, i.e. Shenqi Pill (SP), Yougui Pill (YP), and Yougui Drink (YD) based on rough set, thus exploring the law of compatibility between the core herbs and the edge herbs as well as the law of compatibility between the yang-tonifying herbs and the yin-tonifying herbs in the core herbs.

METHODSThe rats were divided into the normal group, the Shen-yang deficiency model group, and the original prescription group, the core herbs group, and the edge herbs group of this three categorized formulas for tonifying Shen yang, 11 groups altogether. Thyroxine (T4), cortisol (CORT), and testosterone (T) were detected respectively. The decision rules model based on rough set was set up, the interactions between various herbs were analyzed according to the decision rules.

RESULTSThere were synergies between yam and cinnamon, yam and aconite, as well as yam and wolfberry. Poria alisma, Cortex Moutan, and oriental waterplantain tuber had no effect themselves, but they had synergistic effects with the core herbs in SP. Angelica had a certain effect itself, but its functions were different to different core herbs in YP. Licorice had no effect itself, and it was antagonistic with the core herbs in YD.

CONCLUSIONSThe compatibility of core herbs of categorized formula for tonifying Shen yang should focus on benefiting both yin and yang, as well as mutual rooting of yin-yang. Appropriate edge herbs should be chosen for compatibility according to different core herbs. The decision rules model based on rough set has a good prospect in exploring the law of compatibility of the categorized formulas.

Animals ; Drug Incompatibility ; Drugs, Chinese Herbal ; administration & dosage ; Male ; Rats ; Rats, Sprague-Dawley

Basic research of categorized formulae (CF) is one of the approaches to understand the scientific basis of formula assembling and syndrome differentiation in Chinese medicine. In this paper, the common features of CF researches were discussed. The authors held that the four issues, namely, the links between CF-syndrome-diseases, the compatibility of herbs in the core of CF, the comparison of similarities and differences in various kinds of CF, and the identification of effectual substantial basis of CF, are the kernel problems should be solved in CF research, also the scientific intension for elucidating the complex series of Chinese medicine prescriptions, revealing the rules of formula assembling and developing new drugs.
Drug Incompatibility ; Drugs, Chinese Herbal ; therapeutic use ; Medicine, Chinese Traditional ; methods ; Phytotherapy ; methods

Compatibility chemistry of acid-alkaline pair medicines in formulas of traditional Chinese medicine (TCM) is an important research field which should merit to pay attention. The ideas and methods in prescription compatibility research on formulas containing alkaline-acid pair medicines were summarized from the aspect of chemical groups of alkaline and acid ingredients; the research results were introduced and analyzed; the research meaning was elaborated; and the expectation of the field was viewed.
Animals ; Chemistry, Pharmaceutical ; methods ; Drug Incompatibility ; Drugs, Chinese Herbal ; chemistry ; Humans ; Medicine, Chinese Traditional ; Research

What is the pharmacodynamic active components in Chinese medical prescription is a key problem in urgent need to solve for the development of traditional Chinese medicine (TCM). A new thinking of TCM research, "analysis of prescription for special disease/syndrome--compatibility of absorbed/metabolized components from original prescription", was proposed firstly, to analyze and seek out the components or metabolites originated from the administered prescription in blood serum of the organisms with special disease and syndrome. Secondly, to study the compatibility of these absorbed/metabolized components. Then, using a homogeneous design to find out the contribution of each component to the effectiveness of the prescription, eliminate the irrespective or contra-orientation effected components, so as to form the best combination of various components for the prescription with the optimal therapeutic efficacy. By this way, the validity of the prescription with new formed combination could be ensured, not only the predominance and characteristic of combined utilization of traditional Chinese drugs be retained, but also the pharmacodynamic components of the refined prescription be identified, a new prescription with clear pharmacodynamic constitution be obtained and the dispensing relation among various components be explained clearly and quantitatively.
Biomedical Research ; Drug Incompatibility ; Drug Prescriptions ; Drug Therapy ; Drugs, Chinese Herbal ; chemistry ; metabolism ; pharmacokinetics ; therapeutic use ; Humans