Researching on 168 drug allergy medical records at Bach Mai Hospital in 1999 showed that: themselves history was 18.5% and family history was 25%. Drug allergy can occur from many ways: oral, injection and contraction. All drugs aslo make allergy, among them antibiotic and epilepsy drug is higher than other drug. Wound form in clinical was multiform as hives, Quincke beriberi, Stevens-Johnson, Lyell syndrome, red skin, and anapphylactic shock. Allergy rate of Beta-lactam antibiotic is the highest. Using drug without indication make allergy reaction with high rate
Drug Hypersensitivity ; Therapeutics ; Hypersensitivity

The clinical and laboratory characteristics of 139 drug-allergy patients with hepatic cell failure at Allergy and Immunology Department of Hospital Bach Mai from 1999-2003. The result: clinical manifestation of hepatic injury due to drug are very diversified including jaundice, yellow-eyed, ascites, conscious disorder, haemorrhage of skin and mucous, dyspepsia. The laboratory result showed that patients were reduced synthetic process of albumin and protid of liver, coagulation defects due to reducing rate of prothrombin, increasing significantly enzyms of liver. The reason of hepatic cell failure include: traditional drug, psychiatry drug and Rifampicin. Antibiotic drug and epilepsy drug have the same rate
Drug Hypersensitivity ; Liver ; Therapeutics

Allergic reaction to drugs (ARTDs) occurs frequently in adults who are usually suffered from many diseases and who require multiple courses of medications. Investigative result showed that: The incidence of ARTDs in elderly is 6.74%, this incidence in patients of Asthma group is 14.7%. The main cutaneous manifestations of ARTDs in elderly patients included: urticaria and erythematous rashes (42.5%), erythrodermie (14.9%), erythematic multiform (21.3%), fixed drug eruptions (12.7%), vesiculobullous eruptions (6.4%).
Drug Hypersensitivity ; aged

56 patients with sulfamide-related allergy were involved in this study. The results showed that almost members of sulfamide family that are used on clinical can cause allergic reactions. Among these, Biseptol and Trimazon are most common. Allergic reactions with sulfamides are delayed. Clinical manifestations of sulfamide allergy are severe with erythroderma, Stevens-Johnson and Lyell syndromes. Elevation of ESR, SGOT and SGPT levels is main laboratory findings. It is taken a long time to treat and solutions of glucocorticoid, Demerol, ascorbic acid are common medications.
Drug Hypersensitivity ; Pharmaceutical Preparations

No abstract available.
Dapsone ; Drug Hypersensitivity

No abstract available.
Drug Hypersensitivity ; Isoxazoles

Summary We describe nine cases of anti-tuberculosis DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome, a potentially serious complication of treatment that led to interruption of treatment, systemic corticosteroid usage and the resumption of treatment with different regimens. All patients had skin rash, six out of nine patients with hepatitis, two out of nine patients had acute kidney injury, five out of nine patients died. All-cause mortality is high in our cohort.
Drug Hypersensitivity Syndrome

As the use of chemotherapeutic agents increased rapidly in recent years, more patients are under the potential risk of chemotherapy related adverse reactions. Multiple regular exposures to the same drug by chemotherapy protocol may increase the risk of sensitization to a chemotherapeutic agent, which can result in hypersensitivity reactions. Once severe hypersensitivity reactions occur, causative drugs should be avoided. However, a substitute with equal efficacy is not always available. When there is no effective alternative, desensitization is a safe tool for maintenance of chemotherapeutic agents causing hypersensitivity reaction. In this review, we introduce the latest knowledge about desensitization protocol for chemotherapeutic agents which are frequently used recently.
Antineoplastic Agents ; Desensitization, Immunologic ; Drug Hypersensitivity ; Drug Therapy* ; Humans ; Hypersensitivity*

Across descriptive sectional study on 489 workers and pharmacists in the pharmaceutical factories No1 and No2 in Hµ Néi from July to August 1997 has shown that the rate of drug allergy in workers and pharmacists was very high (33.9%). The occupational factors influenced significant on the allergy to Beta-lactamin. The rate of drug allergy was direct proportional with ages and exposure duration. In addition to, the family factors also influenced the drug allergy.
Drug Hypersensitivity ; manpower ; Pharmaceutical Preparations

62 patients with tuberculosis experienced the antituberculosis drug allergy transferred to B¹ch Mai hospital in 1997. The reaction of mastocyte catalysis was used to identify the drug allergy. The results have shown that the rate of side effects of streptomycin, rifampicine, ethambutole, RH, PZH, PZA and INH was 73.91%, 64.7%, 63.88%, 59.09%, 40.74% and 16.66%, respectively. The common clinical symptoms were urticaria, itching, rash, and edema in face.
Drug Hypersensitivity ; Pharmaceutical Preparations ; Tuberculosis