Naringin is mainly present in Rutaceae Citrus Pomelo,grapefruit,lime,and its variants of the peel and fruit,which belongs to dihydrogen flavonoids.Studies have shown that naringin has anti-type 1 and type 2 diabetes pharmacological effects,the mechanism of action by inhibiting diabetes-related oxidative stress injury,inflammation,abnormal metabolism of glucose,and other aspects,while a certain degree of delay in diabetes complications (including diabetic cardiomyopathy,diabetic nephropathy,diabetic retinopathy,and diabetic neuropathy).The mechanism of naringin on the mechanism of diabetes mellitus and its complications was studied in order to provide the basis for the development of antidiabetic drug.

Objective To evaluate the efficacy and safety of chitosan in the repair of clinical surgery wounds.Methods The databases of Cochrane Controlled Trials Register (CCTR),Embase database,Medline database,PubMed database,CNKI database,WanFang database,VIP database and Chinese Biomedical Journal Library (CMCC) were retrieved with computer for collecting randomized controlled trials (RCT) about the repair clinical surgery wounds healing.Meta-analysis on all the data are carried out by RevMan 5.0 software.Results There were totally 16 trials and 3414 patients included.The results showed that the wound healing time ofchitosan was significantly shorter than that of the control group [WMD =-0.64,95％CI (-0.69～-0.59),P ＜ 0.000 01],and chitosan can better promote wound healing [RR =1.03,95％CI (1.01～1.04),P =0.0002].In experimental group,postoperativepain were reliever [WMD =-3.49,95％CI (-5.07～-1.91),P ＜ 0.0001],and postoperative infection were reduced [RR =0.49,95％CI (0.33～0.71),P =0.0002].Conclusion The existing evidences indicate that chitosan can shorten postoperative wound healing time,promote wound healing,relieve pain,and reduce infection.However,the study is limited by the quality of included literature,more clinical trials should be done to confirm the effective and safety.

Objective To explore the clinical effect and safety of S-1 combined with paclitaxel in treatment of advanced gastric cancer.Methods 80 patients with advanced gastric cancer accepted in our hospital from Sep.2013 to Dec.2015 were selected and randomly divided into 2 groups.Patients in observation group were given S-l,cisplatin and paclitaxel,and patients in control group were given S-1 and paclitaxel.Then the short term and long term clinical effect and adverse reactions of 2 groups were compared.Results The total effective rate of observation group was 52.50％ (21/40),which was obviously higher than 40.00％ (16/40) of control group (P ＜ 0.05).The median progression-free survival,median overall survival and 1 year survival rate of 2 groups had no great differences.The main adverse reaction of 2 groups were bone marrow suppression and gastrointestinal reactions of grade 0～Ⅱ.The grade of nausea and vomiting of observation group was much lighter than control group (P ＜ 0.05).But the other adverse reaction of 2 groups had no differences.Conclusion Using S-l,cisplatin and paclitaxel has good effect in treatment of advanced gastric cancer,which is safety and worthy of clinical applications.

Objective To discuss the efficacy and safety of sodium tanshinone ⅡA combined with edaravone in treatment of acute cerebral infarction.Methods 100 cases of acute cerebral infarction were randomly divided into two groups.The control group (50 cases) was treated with edaravone.The observation group (50 cases) was treated with sodium tanshinone ⅡA combined with edaravone.The efficacy of sodium tanshinone ⅡA combined with edaravone in treatment of acute cerebral infarction was evaluated by the efficacy at 1 month after treatment,ESS scores,SF-36 scores before and after treatment and adverse reaction during treatment.Results After treatment,the effective rate of observation group was 90.0％ and control group was 72.0％.The effective rate of observation group was higher than that of the control group (P ＜ 0.05).Compared with the value before treatment,the ESS scores of two groups were increased after treatment (P ＜ 0.05).3 d,7 d,14 d after treatment,the ESS scores of observation group was higher than that of the control group (P ＜ 0.05).Before treatment,there were no statistical significance on SF-36 between two groups.After treatment,the SF-36 scores were increased in two groups (P ＜ 0.05).During treatment,there were no statistical significance on adverse reaction between two groups.Conclusion Sodium tanshinone ⅡA combined with edaravone had a good therapeutic effect on acute cerebral infarction.It could improve the quality of life and neurological function with high safety.It was worthy of clinical application.

Objective To explore the curative effect of bisoprolol fumarate combined with wenxin granule for patients with heart failure complicated with premature ventricular.Methods 132 patients with heart failure and premature ventricular complexes were enrolled in our hospital from January 2013 to January 2016,and which patients divided into two groups,bisoprolol fumarate group (Group BF,n =66) accepted bisoprolol fumarate treatment (5 mg/time,1 times/day),and bisoprolol fumarate combined with wenxin granule group (Group BW n =66) adopted wenxin granule (9 g/time,3 times/day) based on the patients in Group BF.After 4 weeks treatment,the curative effect of all patients were evaluated with electrocardiogram monitor and cardiac ultrasound examination,and the plasma NT-proBNP concentration and hemorheology indexes were analyzed compared with pre-treatment.Results The recovery of ventricular function in Group BW was better significantly than that patients in Group BF from the cardiac ultrasound examination (P ＜ 0.05);The total relieved effective of clinical symptom,premature ventricular complexes and heart failure in Group BW were more remarkable than those in Group BF,and which difference from them was significance (P ＜ 0.05);The blood viscosity,plasma viscosity,plasma fibrinogen and plasma NT-proBNP concentration in patients with Group BW were significantly lower than those Group BF (P ＜ 0.05).Conclusions The clinical curative effect of bisoprolol fumarate combined with Wenxin Granule for heart failure complicated with premature ventricular was more remarkable compare with bisoprolol fumarate single treatment,and which possessed the relative safety.

Objective To investigate the effect and influence on inflammatory factors of salbutamol aerosol combined with montelukast in treatment of cough variant asthma.Methods From Jan 2015 to Jan 2016,120 cases of cough variant asthma in our hospital were selected as the subjects.They were randomly and equally divided into 2 groups:control group (n =60) were treated with salbutamol aerosol,and observation group were treated with salbutamol aerosol and montelukast.The clinical effects,the pulmonary function and the serum inflammatory factors were compared between the two groups.Results After 2 months of treatment,the effective rate of the control group and the observation group were 73.3％ and 96.7％ respectively,there was statistical differences between two groups (P ＜ 0.05).The FEV1 and FEV1/FVC of both groups showed remarkable increase.The FEV1,FEV1/FVC of observation group were (2.21 ± 0.17) L,(66.10 ± 4.46)％,and the FEV1,FEV1/FVC of control group (1.82 ± 0.11) L,(52.48 ± 3.34)％.The difference between two groups was statistically significant (P ＜ 0.05).The IL-6 and TNF-α of both groups showed remarkable decrease.IL-6 and TNF-α in observation group were significantly lower than those of control group (14.58 ± 2.90 vs.20.87 ± 3.26,P ＜ 0.05;0.59 ± 0.12 vs.0.97 ± 0.15,P ＜ 0.05).Conclusion The use of montelukast combined with salbutamol aerosol in the treatment of cough variant asthma was safe and effective,and could significantly improve pulmonary function and reduce inflammatory factor.

Objective To evaluate the efficacy and safety of different doses Octreotide combined with Lansoprazole in the treatment of hepatocirrhosis with upper gastrointestinal bleeding.Methods Eighty hepatocirrhosis patients with upper gastrointestinal bleeding during May.2013 to May.2016 were treated with Octreotide combined with Lansoprazole,and were divided into high dose group (40 cases) and low dose group (40 cases) according to different doses Octreotide.Before and after treatment,portalvenousmaximumvelocity (PVV) and portalveindiameter (PVD) were detected by color Doppler ultrasound respectively,and haemostatic time,blood transfusion cases and volume,rehaemorrhagia cases were recorded,and adverse reactions were observed.Results After treatment,PVV and PVD of the two groups were significantly ameliorative (P ＜ 0.05),and there were no significantly different between two groups.Haemostatic time,blood transfusiorate,blood transfusiorate volume and rehaemorrhagia rate of the high dose group were significantly less than the low dose group (P ＜ 0.05).The clinical effective rate of the high dose group was significantly higher than that of the low dose group (P ＜ 0.05).The rate of adverse reactions of the high dose group was not significantly different from that of the low dose group.Conclusions High doses Octreotide combined with Lansoprazole in the treatment of hepatocirrhosis with upper gastrointestinal bleeding have a gain on hemostatic effect,and cannot increase adverse reactions significantly.

Objective To investigate the effect of L-carnifine on the anemia of renal anemia and its effect on endothelin and left ventricular remodeling in maintenance hemodialysis patients.Methods 206 patients with uremia who underwent hemodialysis for more than 6 months from November 2010 to November 2014 were randomly divided into study group and control group (n =103),control group (n =103).Patients in the study group were treated with intravenous injection of levocarnitine injection on the basis of the control group.After 6 months of treatment,the clinical curative effect of the two groups was observed.Results After treatment,the levels of Hb and HCT were significantly increased,ET levels were significantly reduced,in which the change of patients in the study group was significantly better than the control group (P ＜ 0.05);LAD,LVDs and LVDd of the two groups were different (P ＜ 0.05).The difference between the two groups was statistically significant (P ＜ 0.05).Conclusion L-carnitine combined with erythropoietin in the treatment of renal hemodialysis patients with renal anemia can improve the therapeutic effect,reduce plasma endothelin levels,effectively improve or inhibit the occurrence and development of left ventricular remodeling,effective prevention of heart failure,The effect is remarkable,can promote the use.

Objective To investigate the effect of different doses of ambroxol on efficacy and lung function of elderly patients with chronic obstructive pulmonary disease.Methods 200 patients with COPD were selected.They were divided into two groups randomly.The high dose group (102 cases) were given anmbroxol hydrochloride in high doses.The low dose group (98 cases) were given anmbroxol hydrochloride in low doses.The effect of different doses of ambroxol on efficacy and lung function of elderly patients with chronic obstructive pulmonary disease was evaluated by the efficacy,TNF-α,CRP,pulmonary function indexes and adverse reaction during treatment.Results The effective rate was 89.2％ in the high dose group and 75.5％ in the low dose group.The effective rate of high dose group was higher than that of the low dose group (P ＜ 0.05).Before treatment,there were no statistical significance on CRP and TNF-α between two groups.After treatment,the CRP and TNF-α were decreased in two groups and lower in the high dose group (P ＜ 0.05).Before treatment,there were no statistical significance on FVC,FEV1 and FEV1/FVC％ between two groups.After treatment,FVC,FEV1 and FEV1/FVC were increased and higher in the high dose group (P ＜ 0.05).During treatment,there were no statistical significance on adverse reaction between two groups.Conclusion High dose of ambroxol was effective and safe for COPD.It could reduce inflammation and improve pulmonary ventilation with clinical use.

Objective To investigate the clinical efficacy of dl-3n-butylphthalide and its effect on NT-proBNP levels and inflammatory cytokines of patients with acute cerebral infarction.Methods Total 118 patients with acute cerebral infarction in Hengshui Fifth People's Hospital were randomly divided into control group and observation group.Sixty patients in control group were treated with conventional medication,and 58 patients in observation group were treated with dl-3n-butylphthalide injection based on conventional medication.The NT-proBNP levels,score of neurological deficits (NIHSS),inflammatory cytokines including hypersensitive C-reactive protein (hs-CRP),interleukin-6 (IL-6),and tumor necrosis factor-cα (TNF-α) before and after 7 and 14 d of treatment,and adverse reaction were observed and analyzed.Results Before treatment,differences in the NT-proBNP levels,NIHSS score,hs-CRP,IL-6,and TNF-α between two groups were not obvious.After 7 and 14 d of treatment,NT-proBNP levels in observation group were significantly lower than those in control group (P ＜ 0.05).And after treatment for 14 d,NIHSS score in observation group were conspicuously lower than those in control group (P ＜ 0.05).Additionally,the levels of hs-CRP,IL-6,and TNF-α in observation group were markedly lower than those in control group (P ＜ 0.05).Conclusion D1-3n-butylphthalide injection has a good ability in inhibiting NT-proBNP levels and inflammatory cytokines,and improves the neurological function of patients with acute cerebral infarction.