Gastric duodenal ulcer is a popular disease in the world as well as in Vietnam, it caused large expense about health care and complications can induce dangerously for life. The study on situation of drug use to help for gastrointestinal department has comprehensive picture about situation and contribution to the increase of better treatment quality in future
Prescriptions, Drug ; Evaluation Studies

BACKGROUND: The Korean Journal of Dermatology and the Annals of Dermatology are representative journals of dermatology in Korea. Evaluation of their content, authors and affiliations are valuable for our understanding of the situation, trends and interests of the Korean dermatologic society. OBJECTIVE: To analyze the original contributions in the major dermatology journals of Korea, and compare these with those of renowned international dermatology journals in terms of original contribution. METHODS: A total of 318 original articles from the last 3 volumes of the Korean Journal of Dermatology (2003, vol. 41 to 2005, vol. 43) were collected and analyzed for their characteristic features, such as categories, authors, and affiliations. We also compared these characteristic features with those of 18 original articles from the last 3 volumes of Annals of Dermatology (2003, vol. 15 to 2005, vol. 17), an English dermatologic journal in Korea. RESULTS: Thirty-two percent of original articles fell into the category of drug evaluation and clinical research, followed by laboratory and experimental research. Most articles had three to six co-authors (78%), and one (55.3%) or two (31.1%) affiliations. The number of articles by a specific corresponding author ranged from one to eight, and the majority of articles by a specific corresponding author were one (43.6%) during 3 years. These situations were similar with those of the Annals of Dermatology. The evaluation of the Korean Journal of Dermatology about charateristics of original articles showed a small number of original articles by a corresponding author and cooperative researches with other afilliations. The main subjects of articles were centralized to 3 major categories in the Korean Journal of Dermatology, whereas the other famous international journals showed a relatively uniform distribution. CONCLUSION: The participation of non-dermatologists was fewer in the Korean journals than the other famous international journals. The Korean dermatologic society should make an effort to involve the specialists of other fields in submitting excellent original articles to the Korean Journal of Dermatology. And for the academic position of the Korean dermatologic society, we should make an effort to register one of our journals to the SCI (science citation index). The Korean Journal of Dermatology should deal with more varied articles from new categories for a more uniform distribution of themes. It should also make more effort to improve the Korean Journal of Dermatology.
Dermatology* ; Drug Evaluation ; Korea* ; Specialization

Drug Evaluation, Preclinical/*methods ; Statistics

Antitussive Agents/*pharmacology ; Drug Evaluation, Preclinical/methods

Antitussive Agents/*pharmacology ; Drug Evaluation, Preclinical/methods

In the process of new drug discovery, the application of virtual screening can enrich active compounds, reduce the cost of drug screening, and increase the feasibility of drug screening. Therefore virtual screening technology has become an important approach for new drug discovery. As virtual screening and bioactivity screening possess different advantages, their combination can effectively promote new drug discovery. In the present paper, the application and the trend of removal of non-drug compounds, removal of false positive compounds, pharmacophore searching, molecular docking, and molecular similarity in the process of drug discovery are introduced in order to obtain more benefit from virtual screening strategy for new drug discovery.
Drug Design ; Drug Discovery ; Drug Evaluation, Preclinical ; Models, Molecular

A simple model organism Caenorhabditis elegans has contributed substantially to the fundamental researches in biology. In an era of functional genomics, nematode worm has been developed into a multi-purpose tool that can be exploited to identify disease-causing or disease-associated genes, validate potential drug targets. This, coupled with its genetic amenability, low cost experimental manipulation and compatibility with high throughput screening in an intact physiological condition, makes the model organism into an effective toolbox for drug discovery. This review shows the unique features of C. elegans, how it can play a valuable role in our understanding of the molecular mechanism of human diseases and finding drug leads in drug development process.
Animals ; Caenorhabditis elegans ; Drug Discovery ; Drug Evaluation, Preclinical

China Food and Drug Administration didn't issue any guideline on the pre-clinical study of drug-eluting coronary stent system, the basic requirement of the authorized administration was summarized to help manufacture prepare the document during the registration process.
China ; Drug Evaluation, Preclinical ; methods ; Drug-Eluting Stents ; Guidelines as Topic

Modern and international studies on new traditional Chinese medicines are the main trend of the development of traditional Chinese medicines at present. In Australia, new traditional Chinese medicines refer to complementary medicines, which are mainly registered and launched as listed medicines. The application documents of registered (listed) medicines in Australia mainly cover detailed description of active pharmaceutical ingredients, pharmacological and toxicological studies, dosage form and adverse effects. Each part has detailed specifications and instructions, which helps ensure that applicants could accurately understand the requirements in application for registering (listing) medicines, and provides very important reference to the studies and development of new traditional Chinese medicines in China.
Australia ; Drug Approval ; Drug Evaluation ; Medicine, Chinese Traditional

Assessing response to therapy allows for prospective end point evaluation in clinical trials and serves as a guide to clinicians for making decisions. Recent prospective and randomized trials suggest the development of imaging techniques and introduction of new anti-cancer drugs. However, the revision of methods, or proposal of new methods to evaluate chemotherapeutic response, is not enough. This paper discusses the characteristics of the Response Evaluation Criteria In Solid Tumor (RECIST) version 1.1 suggested in 2009 and used widely by experts. It also contains information about possible dilemmas arising from the application of response assessment by the latest version of the response evaluation method, or recently introduced chemotherapeutic agents. Further data reveals the problems and limitations caused by applying the existing RECIST criteria to anti-cancer immune therapy, and the application of a new technique, immune related response criteria, for the response assessment of immune therapy. Lastly, the paper includes a newly developing response evaluation method and suggests its developmental direction.
Drug Therapy* ; Evaluation Studies as Topic ; Lung Neoplasms* ; Lung* ; Methods ; Prospective Studies ; Response Evaluation Criteria in Solid Tumors