Cellulose was prepared successfully from rice straw by alkali and acid method and bleached by hydrogen peroxide. The effects of percentages of sodium hydroxide, hydrogen peroxide and bleaching method on quality of the cellulose were studied. The product meets requirements of the pharmaceutical grade and may be applied for producing tablets.
cellulose ; Drug Compounding

Microcrystalline cellulise was prepared successfully from cellulose was prepared successfully from cellulose of rice straw by selective hydrolytic method in dilute hydrochloride acid. Effects of percentages of hydrochloride acid, duration of hydrolysis process on productivity and coloration of the Microcrystalline cellulose collected were studied. The product was standardized and complied with it is standard. The product may be applied for producing tablets.
cellulose ; Drug Compounding

Bagasse, an abundant available waste has high -cellulose content (more than 38%) and less than 1.5% as content. In Vietnam, bagasse from refinery at VietTri, VanDiem has cellilose content more than 48%. Powdered cellulose, which is used as a tablet diluent, can be prepared from bagasse. Product is a white powder and loses less than 5.7% of its weight when dried. The supernatant liquid of a 10% dispersion in water has a pH of 7.02.
cellulose ; Drug Compounding

Purpose: Use experimental scheme to find some optimal conditions for reaction of acylized N-phtalyl chitosan stage. Material: green clawed shrimp shell. Preparing following modified water-heat method. Divide into 2 stages: Preparation N-phtalyl chitosan and soluble film created agent in the intestine in optimal conditions. Result: Derivative can be used to make a soluble film created agent in the intestine like CAP, HPMCP.
Chitosan ; Drug Compounding

Semi synthesis of a derivative of chitosan from shrimp shell, which is called Acetyl phtanyl chitosan. Material: green clawed shrimp, pure chemical. Preparation according to heat-water therapy including 2 stages; Preparation N-phtalyl chitosan and derivative of chitosan with property "film created substance dissolves intestine". Film have property which not dissolve in water, solution of HCl 0.1N, pH 1.3; but well dissolves in solution of phosphate pH6. This derivative can be used to make the film created substance that dissolved in intestine.
chitosan ; Drug Compounding

4-chloroanilline, 5-chlorosalicylanilid and 3,5-dichlorosalicylic acid are obtained by chlorination aniline and salicylic acid in difference conditions. Condensation of the above compounds with aniline, salicylic acid and each other to get chlorosalicylanilid derivatives. Chlorosalicylanilid derivatives have high antibiotic and antifungal activity. All most of chlorosalicylanilid derivatives has low toxicity.
Drug Compounding ; chemical synthesis

A titration in nonaqueous medium was proposed to determine simultaneously the mixtures of Chlorpheniramine maleat and the other halogen salts (Dextromethorphan HBr and phenylpropanilamin HCl). The first one was assayed for having the equivalent point EP1. For the second halogen salts we added (CH3COO)2 for liberating halogen radicaux and trans forming to base form. This form was recorded the equivalent point EP2.
Chlorpheniramine ; Drug Compounding

5 thiourea derivatives were synthesized by condensation of 4- chlorophenylisothiocyanat with p-aminobenzoic acide and its derivatives. Condensation of 4-chlorophenylisothiocyanat with phenylhydrazine derivatives to give 2 thiosemicarbazid derivatives. The structure of the obtained products was determined by elementary analysis and IR spectroscopy. The study indicated that all of them have effect on bacteria Gram (+) but this effect on Gram (-) bacteria was weaker. All most of them have effect on Microsporum gypseum and Tricophyton mentagrophytes. Two compounds have effect on candida albicans.
Drug Compounding ; Antifungal Agents ; Anti-Bacterial Agents

Condensation of 4-chlorophenylisocyanat with amine compounds (p-amino salicylic acide, phenyl hydrazine derivatives) gets 7 thiourea derivatives. The structures of the obtained products were determined by elemental analysis and IR spectroscopy. The study indicated that all of them have strong effect on bacteris Gram(+) but weak on GR(-). Six compounds have affected on Microsporum gypseum and Tricophyton mentagrophytes. Two compounds have effects on Candida albicans.
Antifungal Agents ; Anti-Bacterial Agents ; Drug Compounding

The development of biotechnology and the in-depth research on disease mechanisms have led to increased application of enzymes in the treatment of diseases. In addition, enzymes have shown great potential in drug manufacturing, particularly in production of non-natural organic compounds, due to the advantages of mild reaction conditions, high catalytic efficiency, high specificity, high selectivity and few side reactions. Moreover, the application of genetic engineering, chemical modification of enzymes and immobilization technologies have further improved the function of enzymes. This review summarized the advances of using enzymes as drugs for disease treatment or as catalysts for drug manufacturing, followed by discussing challenges, potential solutions and future perspectives on the application of enzymes in the medical and pharmaceutical field.
Biocatalysis ; Biotechnology ; Catalysis ; Drug Compounding ; Enzymes/metabolism*