Cannabis sativa,with a long history of cultivation, is a traditional industrial crop widely used for food, textiles, and me-dicine. This study discussed industrial C. sativa and medicinal C. sativa. According to the characteristics of management policies of C. sativa in different periods, we divided the development stages of C. sativa into three stages and analyzed the changes in breeding and cultivation goals under the influence of policies. Meanwhile, a comprehensive analysis was carried out based on the breeding conditions of industrial C. sativa in China. Because of the vast territory of China, the differences in agricultural planting environment, economic development, and social development in the southern and northern areas result in different used parts of C. sativa. To be speci-fic, flowers and leaves are used in Yunnan, fiber in Heilongjiang, and seeds in Shanxi. The breeding of C. sativa varieties highlights fiber, seeds, or both of them. As the value of cannabidiol is explored, medicinal C. sativa has been approved in recent years. Based on the cultivation characteristics and value of industrial C. sativa, it is proposed that industrial C. sativa has a broad application prospect as an important industrial crop, and the existing products contain almost no tetrahydrocannabinol. The cultivation of C. sativa should be rationally guided to promote the development of the C. sativa industry. Moreover, it is recommended to actively apply advanced breeding techniques such as molecular breeding to overcome the problems of the uncertainty of the existing induced breeding and the excessively long hybrid breeding cycle, and develop high value-added applications such as medicinal products of C. sativa to enhance the exploitation of the economic value of C. sativa.
Cannabidiol/analysis* ; Cannabis/genetics* ; China ; Dronabinol ; Plant Breeding

OBJECTIVES: To establish a high performance liquid chromatographic （HPLC） method for simultaneous determination of three effective constituents, including tetrahydrocannabinol （THC）, cannabidiol （CBD） and cannabinol （CBN） in Cannabis plants. METHODS: A C₁₈ column was used in this study, and acetonitrile-phosphate buffer （0.015 mol/L KH₂PO₄） was used as mobile phase at a flow rate of 1.0 mL/min. At a detection wavelength of 220 mm, UV absorption spectra were collected at the wavelength range of 190-400 nm, and the spectra and retention time were counted as qualitative evidence. RESULTS: THC, CBD and CBN could be well separated by this method. Three components had good linear relationship in the range of 0.4-40 μg/mL （R²≥0.999 3）. The recoveries were over 87%. The limits of detection were 1.8 ng, 2.0 ng and 1.3 ng, respectively. The relative standard deviation （RSD） were less than 5% for both inter-day and intra-day precisions. CONCLUSIONS Reversed-phase HPLC method is simple, rapid and accurate, and it is suitable for the qualitative and quantitative detection of THC, CBD and CBN in Cannabis plants.
Cannabidiol/analysis* ; Cannabinol/analysis* ; Cannabis/chemistry* ; Chromatography, High Pressure Liquid ; Dronabinol/analysis*

BACKGROUND/AIMS: As one of biological modifiers of immune reaction, thymomodulin is known to be peptide derivatives of thyrnic acid. Lysate, and thymomodulin can stimulate antibody formations by increasmg the functions of B and T tymphocytes. Furthermore, GM-CSF and TNF can be released by thymomodulin resulting in relief from bone marrow suppression. And these actions of thymomodulin affer a new therapeutic modality in chronic diseases ot the liver as well as chronic hronchitis. Although interferons are frequently under trials for chronic viral hepatitis B. anothersome of side etTec ts and cost effectiveness is often refractory to be used. Herein, this study was intended to estimate the effectiveness and side effects of per oral thymomodulin. METHODS: Forty one patients with chronic viral hepatitis showing positivity of HBsAg over 6 months were treated with per oral thymomodulin (15mlAmg/ml, h vice daily, over 6 months), Clinical data of preand post-trial states were prospectively investigated. RESULTS: As a result, negative conversion of HBV DNA izvealed 20.6% out ol 34 patients showed HBsAg positivity. HBeAg was isappeared in 10.4 % among the 29 cases. Only two cases were shown the clearance of HBsAg. However. These data are statistically insignificant in comparison to the control group (p>0.05, chi-square test). The desirable effects were noticed as disappearance of acne in 5 cases, and amelioration of menstrual abnormalities in 3 cases. Undesirable side effects were only mild nausea in 3 cases, and indigestion in 2 cases. CONCLUSIONS: On thc basis of these data, it is suggested that oral thymomodulin is an easy and safe therapeutic approach in chronic viral hepatitis B but remains to be heralded by long-term clinical trials.
Acne Vulgaris ; Bone Marrow ; Chronic Disease ; Cost-Benefit Analysis ; DNA ; Dronabinol ; Dyspepsia ; Granulocyte-Macrophage Colony-Stimulating Factor ; Hepatitis B e Antigens ; Hepatitis B Surface Antigens ; Hepatitis B* ; Hepatitis* ; Humans ; Interferons ; Liver ; Nausea ; Prospective Studies