Objective To investigate the therapeutic effect of Qingre-Jiedu formula combined with negative pressure drainage for hand trauma infection. Methods A total of 108 patients with hand trauma infection were randomly divided into 2 groups, 54 cases in each group. The observation group were given Qingre-Jiedu formula combined with vacuum sealing drainage treatment, and the control group only received the treatment of vacuum sealing drainage. After 14 days' treatment, the score of wound secretion and granulation tissue were recorded, and ELISA method was used to detect IL-6, TNF-α detected by immune measure method, and the wound healing and healing time were recorded after treatment. Results After treatment, the secretion score (1.6 ± 0.4 vs.2.2 ± 0.4,t=4.659), granulation tissue score (1.7 ± 0.2 vs.2.2 ± 0.3, t=4.541) in the observation group were significantly lower than those in the control group (P<0.01); the serum IL-6 (64.89 ± 2.31 μg/L vs.72.18 ±3.02 μg/L,t=9.562),TNF-α(318.67 ±15.21 μg/L vs.397.49 ±17.63 μg/L,t=15.611)were significantly lower than those in the control group (P<0.01). The wound healing rate of the observation group was 96.3% (52/54), and control group was 55.6% (30/54), where there was significant difference between two groups (χ 2=24.518,P<0.01); the wound healing time in observation group (15.2 ± 3.0 d vs.25.2 ± 4.7 d, t=11.551) was significantly shorter than that in the control group (P<0.01). Conclusions The Qingre-Jiedu formula combined with negative pressure drainage for hand trauma infection could promote wound healing, improve healing effect and reduce the level of inflammatory reaction..