Objective To investigate the change trend for D-dimer,antithrombin activity (AT:A),tissue plasminogen activator(t-PA),plasminogen activator inhibitor-1 (PAI-1)and yon Willebrand factor (vWF) before and after treatment in patients with cerebral infarction,so as to evaluate the clinical value of the above parameters in therapeutic effect monitoring of cerebral infarction.Methotis SYSMEX CA7000 blood coagulation analyzer was applied to determining plasma D-dimer,t-PA,PAI-1 and AT:A,and ELISA was adopted to measure vWF.Results Compared with those of healthy control group,D-dimer,PAI-1 and vWF were significantly increased (P<0.01),t-PA was significantly decreased (P<0.01),and AT:A had no change (P>0.05) in cerebral infarction group before treatment.In cerebral infarction group,compared with those of pre-treatment,D-dimer,PAI-1 and vWF were significantly decreased (P<0.01),t-PA was significantly increased(P<0.01),and AT:A had no change(P>0.05) after treatment.So was the situation between GCS>8 and GCS≤8group.Conclusion There are obvious changes of fibrinolytic system parameters and vWF level befor and after treatment in patients with cerebral infarction,and the changes are associated with the course of disease.

Cytokine-induced killer cells (CIKs) are a kind of non-MHC restricted cytotoxic T cells that have been recognized as the best adoptive immunotherapy against tumor. Dendritic cells(DCs) play a pivotal role in the interaction between tumor cells and T cells. Coculture of CIKs and DCs enhances the proliferation rate and cytotoxicity of CIKs, and has been shown to have strong cancer killing effects in various organ sites.

Chimeric antigen receptor T lymphocyte immunological therapy (CAR-T)is a new oncologic immunotherapy in recent years,which has been widely used in patients with leukemia and lymphoma and achieved a certain effect.Neuroblastoma is one of the most common extracranial solid tumors in children and over 50％ of patients have metastatic recurrence when first diagnosed.The prognosis for the high-risk neuroblastoma remains poor at the moment and it's time to look for new treatments.In this review,we summarize the basic structure and development of CAR-T,discuss the principles and risks of CAR-T in the treatment of neuroblastoma,and give an outlook to CAR-T in the treatment of solid tumors.

Objective:To investigate the effect of cilostazol on erectile function in diabetic rat model.Methods:Diabetes were induced in 50 male adult sprague-dawley(SD) rats by an intraperitoneal injection of streptozotocin.The DM rats were randomly divided into diabetic group(DM group )and cilostazol therapy group(CI group) 8 weeks after the injection(another 10 normal SD rats as control,C group).The rats in each group were treated with cilostazol20 mg/(kg?d) or NS through a gastric perfusion for 8 weeks.Then the erectile function of all these rats was evaluated by apomorphine.Motor nerve conduction velocity of sciatic nerve(MNCV) was evaluated by electrophysiology method.Their penis tissues were harvested to measure the level of nitric oxide synthase(NOS) by colorimetric method,and the penile cell apoptosis of smooth muscle was analyzed by TUNEL assay.Results:The erectile function,MNCV and NOS level in CI group significantly increased,while the apoptosis ratio significantly decreased(P

Female ; Hepatitis B virus ; Hepatitis B, Chronic ; drug therapy ; Humans ; Pregnancy

With the arrival of knowledge information age,the management of university scientific research is faced with the new opportunity as well as the challenge.This paper has made a brief analysis to the present situation of university scientific research management service,and discussed the way to improve the management level of university scientific research from aspects of humanist,overall development,coordinated development and sustainable development in the further study and practice the scientific concept of development activities,and discussed the way to improve the management of university scientific research.

Objective To study the effect of FK506 pretreatment on endotoxin shock induced by LPS. Methods 155 mice of the Kunming strain were randomly divided into LPS group (n=80) and LPS|FK group (n=75). An endotoxin shock model of mice was reproduced by an intraperitoneal injection of LPS (25ml/kg for each mouse). Beginning from 2 days before the reproduction of the model, each mouse of the LPS+FK group were given 20ml/kg of FK506 q 12 h, by gastric gavage while animals of the LPS group were given an equal amount of 0.9% sodium chloride solution in the same way. The survival time of 20 mice of the LPS group and 15 mice of LPS+FK group was observed. 10 mice of each group were sacrificed at 0,0.5,2,4,6 and 8 hours after the injection of LPS, respectively. Blood samples were collected and serum TNF-? and IL-1?, contents, and activiry of ALT and AST were determined. The ratio of the wet weight and dry weight (W/D) of the lung was calculated, and the histopathology of the lung and the liver was studied. Results The mean survival time was longer and the 72h survival rate in mice of LPS+FK group was higher, but the serum ALT and AST activity and serum TNF-? and IL-1? contents were lower than those of LPS group at each time point. The W/D ratio of the lung in animals of both groups at 4,6 and 8 hours after the injection of LPS was greater than that at 0 hour (P

The main objectives of this study was to compare the sensorimdt afar Performance of the unaffected upper extremity of elderly stroke patients with that of healthy elderly people. Methods: The groupof stroke patients was of 30 hemiplegic subjects who had had a cerebrovasculai accident at least 6 monthsearlier. A group of 30 healthy subjects matched for age and sex was used for comparison. The main parameters of the performance of the unaffected upper extremity of the stroke subjects and of the same side of the healthy subjects were measured with valid,reliable instruments. Some variables potentially related to theunaffected upper extremity were also measured:length of time since the stroke,activity level,etc.Results;Statistical analyses showed significant deficits in the unaffected upper extremity of hemiplegic subjecs compared with normal subjects with regard to the following parameters: gross manual dexterity, fine manualdexterity, motor coordination,global performance (P<0. 05 to P<0. 0001 ). No significant clinical or statistical difference was found for grip strength,two-- point discrimination and kindethesia.-- Conclusions: Manyfactors (frequency of use of the unaffected hand sensorimotor interaction task,sevrity of the the deficits in corticifugal projection and deficits in postural stabilization)could interact to provide the clinical picture obtainedin the present study.

Motor imagery therapy is based on the theory of plasticity in the central nervous system. Movement with imagery improved reconstruction of damaged motor conduction pathway, and made restoration of central nervous system. Motor imagery adapts to recovery mode of stroke, and was proved to be effective on motor function when applied with physical therapy for stroke patients. This article would review its background, mechanisms, Methods and effects, etc.

Angiocentric Glioma has been newly identified as an epilepsy associated tumory. Up to now, reported cases are still scarce. The tumor causes drug-resistant epilepsy. On histological findings, monomorphous bipolar tumor cells are arranged around vessels. Imaging studies show that the tumor is diffused or rimlike hyperintensity on T1-weighted SE sequences and a stalklike extension to the ventricle on T2-weighted sequences. The World Health Organization listed this new entity in its fourth edition of the WHO classification of tumors of the central nervous system published in 2007.