BACKGROUNDGastroesophageal reflux disease (GERD) is one of the most common digestive disorder in the world. In this study, we chose Calcitum-6 for GERD treatment and assessed itsimpact on the disease using modern laboratory and imaging study. Out main purpose was to investigate the impact of Calcitum-6 for GERD treatment using gastroscopy.METHODSWe selected 34 patients who meet the criteria of GERD for the study. All participants signed a consent form. After 21 days of treatment with Calcitum-6 patients underwentgastroscopy in the Teaching hospital of MNUMS.RESULTSSymptoms of GERD including heartburn and bitter taste were significantly reduced within 4.7±0.8 days after treatment. Symptoms of bile reflux, increased gastric acid and painwere reduced by 73.6%, 55.2%, and 69.8% (р=0.05), respectively, after the completion of 21 days treatment. Changes in esophageal mucosa were recovered in 83.87% (26) and relapse of gastritis was reduced in 65.52% (19) of all patients.CONCLUSIONSBased on our results, we conclude that using Calcitum-6 for the treatment of GERD shows significant reduction in symptoms of the disease.