1.Interrelationship among sperm motility, sperm morphology and hypoosmotic swelling test in male infertility evaluation and their usefulness in predicting male fertility potential.
Doo Seok CHOI ; Shin Yong MOON ; Yoon Seok CHANG
Korean Journal of Obstetrics and Gynecology 1993;36(7):2497-2509
No abstract available.
Fertility*
;
Humans
;
Infertility, Male*
;
Male
;
Male*
;
Sperm Motility*
;
Spermatozoa*
2.Guidelines for Clinical Management of Premenstrual Syndrome.
Journal of the Korean Medical Association 2005;48(5):465-471
Premenstrual syndrome(PMS) refers to a group of menstruation-related symptoms that impair daily activity and interpersonal relationship. The therapeutic modality for PMS consists of non-pharmacologic and pharmacologic treatment. Generally, after confirmation of PMS, a set of non-pharmacologic treatments is recommended before pharmacologic treatment. Patients can be benefited from non-pharmacological treatments such as patient education, cognitive therapy, behavioral therapy, and dietary supplementation. Pharmacologic therapy including psychotropic agents, diuretics, and prostaglandin inhibitors may be used, when PMS symptoms are not sufficiently improved after non-pharmacologic treatments, or when symptoms fit the diagnostic criteria of premenstrual dysphoric disorder(PMDD). When treatment fails, hormonal therapy to manipulate menstrual cycle may be considered, and several trials showed improvement of physical and mood symptoms.
Cognitive Therapy
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Dietary Supplements
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Diuretics
;
Female
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Humans
;
Menstrual Cycle
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Patient Education as Topic
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Premenstrual Syndrome*
;
Prostaglandin Antagonists
4.Changing pattern of serum leptin concentration in women undergoing clomiphene citrate challenge test or controlled ovarian hyperstimulation.
Doo Seok CHOI ; Jeong Won LEE ; Jin Kyung YOO ; Byung Koo YOON ; Je Ho LEE
Korean Journal of Obstetrics and Gynecology 1999;42(12):2744-2748
OBJECTIVE: To evaluate the changing pattern of serum leptin level and the correlation between estradiol level during the clomiphene citrate challenge test(CCCT) or controlled ovarian hyperstimulation(COH) cycle. METHODS: Twenty-seven women who underwent CCCT and fourteen women who underwent controlled ovarian hyperstimulation were recruited to measure the serum leptin level. After correction of serum concentration with body mass index(BMI), changes of leptin level and correlation with serum estradiol level during CCCT and COH cycle were analyzed. RESULTS: Circulating leptin levels were significantly correlated with BMI at each time point in CCCT cycle(P<0.01). In CCCT cycle, leptin/BMI level was significantly increased at midluteal phase compared to that of menstrual cycle day 3 and 10(p<0.05). In women with regular menstruation, leptin/BMI level at midluteal phase was significantly higher than that of menstrual day 3 and 10, but this difference was not seen in women with irregular menstruation. The leptin/BMI level in COH cycle showed increasing tendency throughout ovarian stimulation. But there was no significant correlation between leptin/BMI and estradiol level in CCCT and COH cycle. CONCLUSION: There is a significant correlation between BMI and circulating leptin level. Midluteal leptin level is significantly higher than that of follicular phase in CCCT cycle, and there is an increasing tendency in leptin level after ovarian stimulation in CCCT and COH cycle without statistical significance. These findings suggest that circulating estradiol concentration has no major influence on circulating leptin level.
Clomiphene*
;
Estradiol
;
Female
;
Follicular Phase
;
Humans
;
Leptin*
;
Menstrual Cycle
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Menstruation
;
Ovulation Induction
5.4 cases of 46,XY pure conadal dysgenesis.
Wan Young KIM ; Sang Seok SHIM ; Doo Seok CHOI ; Do Young HWANG ; Jong Hoon KIM ; Jin Yong LEE
Korean Journal of Obstetrics and Gynecology 1992;35(8):1242-1252
No abstract available.
6.Predictive value of serum beta-hCG level in pregnancies following in vitro fertilization and embryo transfer.
Seok Hyun KIM ; Chang Suk SUH ; Doo Seok CHOI ; Young Min CHOI ; Chang Jae SHIN ; Jung Gu KIM ; Shin Yong MOON ; Jin Yong LEE ; Yoon Seok CHANG
Korean Journal of Fertility and Sterility 1992;19(1):41-48
No abstract available.
Embryo Transfer*
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Embryonic Structures*
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Fertilization in Vitro*
;
Pregnancy*
7.Anastomotic Leakage after Laparoscopic versus Open Resection for Rectal Cancer: A Retrospective Study.
Doo Seok LEE ; Eui Gon YOUK ; Sung Il CHOI ; Doo Han LEE ; Do Sun KIM ; Hong Young MOON
Journal of the Korean Society of Coloproctology 2007;23(5):350-357
PURPOSE: This study is to compare the rate and pattern of anastomotic leakage (AL) for rectal cancer after laparoscopic vs. conventional open surgery at high and low rectal anastomosis and to evaluate whether the number of linear staples used for distal rectal resection is related to AL in laparoscopic group. RESULTS: One hundred ninety-seven patients who underwent a curative resection for rectal cancer between March 2002 and February 2006 were studied retrospectively (107 laparoscopic, 90 open). The proportions of patients with anastomosis above vs. below 5 cm from AV were not different between the laparoscopic and the open groups; (above/below: 54/53 and 41/49, respectively, P=0.57). The protective stoma rate, the overall rate of AL, the rate of AL according to the height of the anastomosis, and the number of distal linear staples were evaluated for both groups. RESULTS: Clinical AL occurred in 11 of 107 patients (10.3%) for the laparoscopic group and in 5 of 90 patients (5.6%) for the open group. The rates of AL in patients without protective stoma were not significantly different for high rectal anastomosis (6.0% for laparoscopic vs. 2.6% for open, P= 0.63) and for low rectal anastomosis (25.8% for laparoscopic vs. 12.1% for open, P=0.21). The risk of AL was 4.9 times higher when 3 linear staples were used than when 2 linear staples were used in the laparoscopic group. CONCLUSIONS: There was no statistical difference in AL between the laparoscopic group and the open group. The rate of AL could be reduced by using fewer linear staples for distal rectal resection in the laparoscopic group.
Anastomotic Leak*
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Humans
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Rectal Neoplasms*
;
Retrospective Studies*
8.Reticulocyte hemoglobin content for the diagnosis of iron deficiency in young children with acute infection.
Jon Soo KIM ; Jun Seok CHOI ; Doo Young CHOI ; Chur Woo YOU
Korean Journal of Pediatrics 2008;51(8):827-833
PURPOSE: Early identification of iron deficiency in young children is essential to prevent damaging long-term consequences. It is often difficult for the pediatrician to know which indices should be used when diagnosing these conditions especially in hospitalized young children. This study investigated the clinical significances of reticulocyte hemoglobin content in young children with acute infection. METHODS: We studied 69 young children aged from 6 to 24 months admitted with acute infection in a single center. Venous blood was drawn to determine hemoglobin (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), hemoglobin content (CH), reticulocyte hemoglobin content (CHr), and red blood cell distribution width (RDW) using ADVIA 120 (Bayer Diagnostics, NY, USA). For evaluating iron status, iron, total iron binding capacity, ferritin and transferrin saturation (Tfsat) were determined. Iron deficiency was defined as Tfsat less than 20%, and iron deficiency anemia as Tfsat less than 20% and Hb level less than 11 g/dL. RESULTS: In all, 47 were iron deficient; 17 of these had iron deficiency anemia. CHr was the only significant predictor of iron deficiency (likelihood ratio test=71.25; odds ratio=0.67; P<0.05). Plasma ferritin level had no predictive value (P=0.519). Subjects with CHr less than 27.4 pg had lower Hb level, MCH, CH, Tfsat, and iron levels than those with CHr 27.4 pg or more (P<0.05 for all). CONCLUSION: CHr level was a sensitive screening tool and the strongest predictor of iron deficiency in hospitalized infants with acute infection; it was cost saving and avoiding additional sampling. However its reference range should be established.
Aged
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Anemia, Iron-Deficiency
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Child
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Cost Savings
;
Erythrocyte Indices
;
Erythrocytes
;
Ferritins
;
Hemoglobins
;
Humans
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Infant
;
Iron
;
Mass Screening
;
Plasma
;
Reference Values
;
Reticulocytes
;
Transferrin
9.Detection of early pregnancy factor in sera of pregnant women, GIFT(gamete intrafallopian transfer) patients and in human embryo culture media.
Jin Yong LEE ; Jung Gu KIM ; Doo Suk CHOI ; Chul Min LEE ; Young Min CHOI ; Chang Jae SHIN ; Shin Yong MOON ; Yoon Seok CHANG
Korean Journal of Fertility and Sterility 1993;20(3):191-199
No abstract available.
Culture Media*
;
Embryonic Structures*
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Female
;
Humans
;
Humans*
;
Pregnancy*
;
Pregnant Women*
10.Lymph Node Ratio as a Risk Factor for Locoregional Recurrence in Breast Cancer Patients with 10 or More Axillary Nodes.
Sang Won KIM ; Doo Ho CHOI ; Seung Jae HUH ; Won PARK ; Seok Jin NAM ; Seok Won KIM ; Jeong Eon LEE ; Young Hyuck IM ; Jin Seok AHN ; Yeon Hee PARK
Journal of Breast Cancer 2016;19(2):169-175
PURPOSE: We analyzed the association of lymph node ratio (LNR) wth locoregional control (LRC) in breast cancer patients with ≥10 involved axillary lymph nodes who underwent multimodality treatment. METHODS: We retrospectively analyzed 234 breast cancer patients with ≥10 involved axillary lymph nodes between 2000 and 2011. All patients received adjuvant chemotherapy and radiotherapy (RT) after radical surgery. The cutoff value of LNR was obtained using receiver operating characteristic curve analysis. The majority of patients (87.2%) received chemotherapeutic regimen including taxane. RT consisted of tangential fields to the chest wall or intact breast, delivered at a median dose of 50 Gy, and a single anterior port to the supraclavicular lymph node area, delivered at a median dose of 50 Gy. For patients who underwent breast-conserving surgery, an electron boost with a total dose of 9 to 15 Gy was delivered to the tumor bed. RESULTS: Within a median follow-up period of 73.5 months (range, 11-183 months), locoregional recurrence (LRR) occurred in 30 patients (12.8%) and the 5-year LRC rate was 88.8%. After multivariate analysis, LNR ≥0.7 was the only independent factor significantly associated with LRC (hazard ratio, 2.06; 95% confidence interval, 0.99-4.29; p=0.05). CONCLUSION: An aggressive multimodal treatment approach showed favorable locoregional outcome in patients with ≥10 involved axillary lymph nodes. However, patients with a high LNR ≥0.7 still had an increased risk for LRR, even in the setting of current local treatments.
Breast Neoplasms*
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Breast*
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Chemotherapy, Adjuvant
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Combined Modality Therapy
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Follow-Up Studies
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Humans
;
Lymph Nodes*
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Mastectomy, Segmental
;
Multivariate Analysis
;
Radiotherapy
;
Recurrence*
;
Retrospective Studies
;
Risk Factors*
;
ROC Curve
;
Thoracic Wall