2.A study on the postaxial polydactyly of the foot.
Sung Woo KIM ; Sung Pyo HONG ; Doo Hyung LEE
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1991;18(4):727-734
No abstract available.
Foot*
;
Polydactyly*
6.Full-thickness skin graft using the skin stretched by tissue expander.
Young Geun CHO ; Sung Pyo HONG ; Doo Hyung LEE
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1991;18(4):669-675
No abstract available.
Skin*
;
Tissue Expansion Devices*
;
Transplants*
7.A study on the effect of PDGF(platelet-derived growth factor) on wound healing.
Ji Young SONG ; Sung Pyo HONG ; Doo Hyung LEE
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1991;18(5):802-812
No abstract available.
Wound Healing*
;
Wounds and Injuries*
8.Latissimus Dorsi Flap for Breast Reconstruction.
Jin Young KIM ; Sung Pyo HONG ; Doo Hyung LEE
Journal of the Korean Society of Aesthetic Plastic Surgery 1998;4(1):35-44
Breast reconstruction following mastectomy has, become increasingly popular in recent years. Reconstruction surgeons have responded to patients' needs for effective and versatile procedures that will restore the normal shape and symmetry of breasts. Among the various techniques for these purpose, transverse rectus abdominis myocutaneous(TRAM) flap is now cosidered as the most acceptable technique. However, there are some limitations to use the TRAM flap, such as heavy smoker, obesity, and previous abdominal surgery. Also TRAM flaps are not good candidates for the patients with absent anterior axillary fold. In these respects, latissimus dorsi flap can be used as an alternative method for successful breast reconstuction. Latissiomus dorsi flaps have several advantages as compared to TRAM flaps, such as reliable blood supply, versatility of skin paddle orientation, and low donor site morbidity. It is also available for patients without anterior axillary fold, such as radical mastectomy defect or Poland syndrome. Latissimus dorsi flaps, however, and implants to obtain projection and symmetry of the reconstructed breast. Main disadvantages of latissimus dorsi flap method are difference in color and texture between skins of flap and chest, and capsular contracture resulted in high riding implant or distortion of breast contour. In this study, we performed latissimus dorsi flap for reconstruction fo breast and anterior axillary fold in 10 cases. To minimize the above problems more fullness and natural shape, implants were completely covered with muscle and overexpanded for more than 3-months and then deflated to the desired volume. These maneuvers produced aesthetically acceptable results during the latissimus dorsi breast reconstruction.
Breast*
;
Contracture
;
Female
;
Humans
;
Mammaplasty*
;
Mastectomy
;
Mastectomy, Radical
;
Obesity
;
Poland Syndrome
;
Rectus Abdominis
;
Skin
;
Superficial Back Muscles*
;
Thorax
;
Tissue Donors
9.Expression of Matrix Metalloproteinase-2 and -9 in Oral Squamous Cell Carcinomas in Relation to the Histologic Invasiveness and Cellular Differentiation.
Seong Doo HONG ; San Pyo HONG ; Yong Sik KIM ; Jae Il LEE ; Chang Yun LIM
Korean Journal of Pathology 1999;33(4):243-250
A poor prognosis of oral squamous cell carcinoma (SCC) is partly due to the invasiveness and metastasis of the tumor. A key element in tumor invasion and metastasis in the degradation of extracellular matrix is matrix metalloproteinases (MMPs). This study was performed to determine the expression of MMP-2 and MMP-9 of oral SCCs with regard to the histologic invasiveness and differentiation in 5 normal oral mucosa and 36 oral SCCs. The histologic invasiveness of oral SCCs were classified into 4 grades. The differentiation of oral SCCs was divided into 3 grades. The streptavidin-biotin immunohistochemical staining, using MMP-2 and MMP-9 monoclonal antibodies, was performed to determine the expression of MMP-2 and MMP-9. The expression of MMP-2 was positive in 6 of 17 oral SCCs with weak invasiveness and was positive in 7 of 19 oral SCCs with strong invasiveness. The MMP-2 expression did not increase significantly with respect to the invasiveness of oral SCCs (P>0.05). The expression of MMP-9 was strongly positive in 6 out of 17 SCCs with weak invasiveness and was strongly positive in 14 of 19 SCCs with strong invasiveness. The MMP-9 expression increased significantly with respect to the invasiveness of oral SCCs; the stronger the expression, the stronger the invasiveness (P<0.05). The expression of MMP-9 was in 57.9% of well differentiated SCCs, 57.1% of moderately differentiated ones, and 33.3% of poorly differentiated SCCs. The expression of MMP-2 and MMP-9 did not increase significantly with respect to the histologic differentiation. We conclude that with respect to the invasiveness, the MMP-9 expression increases significantly in oral SCCs but the MMP-2 expression does not; and that with respect to the histologic differentiation, their expressions do not increase significantly. These results suggeste that MMP-9 can be used as a tool to evaluate the invasiveness of oral SCCs.
Antibodies, Monoclonal
;
Carcinoma, Squamous Cell*
;
Extracellular Matrix
;
Matrix Metalloproteinase 2*
;
Matrix Metalloproteinases
;
Mouth Mucosa
;
Neoplasm Metastasis
;
Prognosis
10.A STUDY ON THE DEVELOPMENT OF BIOSYNTHETIC SKIN REPLACEMENTS CONSISTED OF FIBROBLASTS GROWN IN BIOBRANE.
Hong Seok KIM ; Sung Pyo HONG ; Jae Kyung PARK ; Doo Hyung LEE
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1997;24(5):875-883
No abstract available.
Fibroblasts*
;
Skin*