1.Studies in serum antithyroglonbulin and antimicrosomal antibodies as screening for postpartum thyroid dysfunction.
Chang Hyuk OH ; Hyung Min CHING ; Soo Nyung KIM ; In Jae CHO ; Doo Ho KIM
Korean Journal of Obstetrics and Gynecology 1993;36(7):1602-1606
No abstract available.
Antibodies*
;
Mass Screening*
;
Postpartum Period*
;
Thyroid Gland*
2.Clinical evaluation of lung cancer confirmed to be dead in the post-operative follow-up periods.
Doo Yun LEE ; Hae Kyun KIM ; Hyo Chae PAIK ; Jae Min CHO ; Sung Nok HONG
The Korean Journal of Thoracic and Cardiovascular Surgery 1992;25(1):86-95
No abstract available.
Follow-Up Studies*
;
Lung Neoplasms*
;
Lung*
3.Erratum: Correction of Title. Correlation Between Lower Urinary Tract Symptoms and Premature Ejaculation in Korean Men Older Than 40 Years Old.
Jae Doo UM ; Dong Il KANG ; Jang Ho YOON ; Kweon Sik MIN
Korean Journal of Urology 2014;55(6):434-434
In this paper, the title was described incorrectly.
4.A study on the medical care expenditure of the uterine cervix carcinoma by clinical stage and treatment modality.
Hyo Ki MIN ; Doo Chae JUNG ; Soo Yong CHOI ; Je Ho LEE ; Jae Kyu LIM
Korean Journal of Epidemiology 1992;14(2):160-174
No abstract available.
Cervix Uteri*
;
Female
;
Health Expenditures*
5.Morphologic change of PCL of MRI in the tear of ACL
Nam Hong CHOI ; Myung Ku KIM ; Yong Jin YOON ; Jae Doo YOO ; Ho Min LEE
The Journal of the Korean Orthopaedic Association 1996;31(2):371-376
MRI has proved to be very reliable in evaluating the menisci and cruciate ligaments. On MRI, several diagnostic criteria of ruptured ACL were reported. Boeree and Ackyroyd reported that when the ACL is ruptured the PCL may appear to be curled up or sigmoid. But these morphologic changes may be shown in the normal ACL, so the quantitative analysis of these morphologic changes in considered as a way to increase the diagnostic sensitivity. We have used 1.0 tesla MRI scanner(SIMENS W. Germany) with a surface coil. We compared two groups of patients; a ruptured ACL group(16 patients) in which had indicated and arthroscopy confirmed rupture of the ACL and control group(46 patients), in which had shown the ACL to be entirely normal. At first, we made a line(basal line) between the femoral attachment and tibial attachment of the PCL and decided the point(apex) which was located far distant from the line. And we made a line(A line) between the femoral attachment and apex of the PCL, another line(B line) between the tibial attachment and apex of the PCL. We divided the basal line into the four areas. We measured the each angle between basal line and A line(angle a), between basal line and B line(angle b). And we measured the entire length of basal line, each height of the PCL previously divided point of the basal line(H1, H2, H3) and the apex of the PCL on the basal line. We compared the control group and ruptured ACL group by t-test from the measured factors angle a, angle b, H1, H2, H3, H4, and length of basal line. We studied factors which were able to decide whether the ACL was ruptured or not in MRI finding by logistic regression. 1. H1, the distance from the basal line to the PCL at 1/4 point on the basal line, were 5.7±1.6 mm in ruptured ACL group, 4.7±1.3 mm in control group, so there was statistically significant increase in ruptured ACL group. 2. The angle a were 56.0±14.4° in ruptured ACL group, 39.7±10.1° in control group, so there was statistically significant increase in ruptured ACL group. 3. From the measured factors angle a was able to decide whether the ACL was ruptured or not in MRI and the slope of angle a in logistic regression was 0.1. In conclusion, when the apex of the PCL is located at proximal 1/4 of the PCL and PCL and greater curve, above signs will be considered to be a sign of ruptured ACL in MRI.
Arthroscopy
;
Colon, Sigmoid
;
Humans
;
Ligaments
;
Logistic Models
;
Magnetic Resonance Imaging
;
Rupture
;
Tears
6.Establishment for Reference Range of Serum HER-2/neu in Korean Healthy Women.
Jae Woo KIM ; Sung Yong KIM ; Hong Soo LEE ; Hee Doo WOO ; Doo Min SON ; Cheol Wan LIM ; Tae Youn CHOI ; Yong Seog JANG ; Jae Jun KIM ; Min Hyuk LEE
Journal of Breast Cancer 2006;9(4):301-308
PURPOSE: HER-2/neu oncogene is known to play a part in the process of carcinogenesis, while the biological characteristics of HER-2/neu oncoprotein include regulating cell growth and increasing the reproductionability of a tumor. The extracelluar domain (ECD), whose molecular weight is between 95 and 105 kD among the HER-2/neu oncoprotein structures, is proteolyzed and separated from the cell surface by metalloproteases and goes into the blood stream where it starts circulation. Since monoclonal antibody was developed for the serum HER-2/neu ECD, it's now possible to measure HER-2/neu ECD in the serum with the immunoassay method. The measurement of serum HER-2/neu ECD is used for prognosis of metastatic breast cancer and for testing the treating effect of trastuzumab (Herceptin(R)), a target agent for the patients positive to the HER-2/neu receptor. In Korea there is no report on the accurate reference range of serum HER-2/neu for healthy women. The purposes of this study were to measure the serum HER-2/neu ECD in healthy Korean women, analyze the reference range. METHODS: The subjects of the study include 200 healthy Korean women with 50 from each in their twenties, thirties, forties, and fifties. As for methodology, the HER-2/neu in the serum separated from their blood was measured. The serum HER-2/neu level was measured quantitatively with the recently developed ADVIA Centaur(R) automated immunoassay analyzer and ADVIA Centaur(R) HER-2/neu assay reagent. With the measurement, you can use the sandwich immunoassay and direct chemiluminescence technique for two monoclonal antibodies for the epitopes located in the serum HER-2/neu ECD. The reference ranges were calculated based on the mean +/- 2 SD. RESULTS: One of the 200 healthy subjects was excluded from analysis for having the highest value of serum HER-2/neu (23.1 ng/ml), and the data of total 199 were used for analysis. The analysis results indicated that the minimum value was 3.5 ng/mL, the maximum value 14.5 ng/mL, the mean 8.6 ng/mL, average 8.77 ng/mL, and SD 1.61 ng/mL. The reference range of the 199 subjects's serum HER-2/neu measurements was calculated by the mean +/- 2 SD. Since the mean +/- SD of their HER-2/neu measurements was 8.8 +/- 1.6 ng/mL, the reference range was 5.6~12.0 ng/mL. The reference ranges for the age groups were 6.1~10.9 ng/mL, 5.3~11.4 ng/mL, 5.0~12.6 ng/mL and 6.3~12.6 ng/mL for the twenties, thirties, forties and fifties, respectively. The reference ranges for the age groups were analyzed statistically and there was statistical difference (p= 0.002) between fifties and twenties or thirties. The upper limit level of the reference range of serum HER-2/neu in healthy Korean women was 12.0 ng/mL. CONCLUSION: The results suggest that the reference range of serum HER-2/neu in healthy Korean women is 6.1~10.9 ng/mL, 5.3~11.4 ng/mL, 5.0~12.6 ng/mL and 6.3~12.6 ng/mL for the twenties, thirties, forties, and fifties, respectively. There is no significant difference between the twenties, thirties, forties, each other. According to analyzed statistically, there is difference between fifties and twenties or thirties (p= 0.002), but there is no statistically significant difference between forties and fifties.
Antibodies, Monoclonal
;
Breast
;
Breast Neoplasms
;
Carcinogenesis
;
Epitopes
;
Female
;
Humans
;
Immunoassay
;
Korea
;
Luminescence
;
Metalloproteases
;
Molecular Weight
;
Oncogenes
;
Population Characteristics
;
Prognosis
;
Reference Values*
;
Reproduction
;
Rivers
;
Trastuzumab
7.Clinical Evaluation of Recurrent Intussusception.
Journal of the Korean Association of Pediatric Surgeons 2003;9(1):24-29
To evaluate the clinical findings of the recurrent intussusception. 351 patients with 445 intussusceptions were reviewed. Recurrence rate, pattern of recurrence, reducibility, pathologic lead points (PLP), and operative findings and long term follow up of the multiple recurrences were analyzed. Of 351 patients, 303 had no recurrence, 26 had one recurrence, and 22 had multiple recurrences. Over all recurrence rate was 16.4% ; 18.5% were managed by air reduction, 16.2% by barium reduction and 5.9% by operation. Elven PLPs were proved operatively operatively and an additional 6 suspected PLPs were depicted radiologically. The most frequent PLP was ileal lymphoid hyperplasia. Intervals between reduction and recurrence were less than 2 weeks in 31 cases, between 2 weeks and 1 year in 55, and more than 1 year in 8. The longest interval was 2 years and 4 months.
Barium
;
Follow-Up Studies
;
Humans
;
Hyperplasia
;
Intussusception*
;
Recurrence
8.Effect of cell-free human amniotic fluid on the develpment of 2-cell stage mouse embryos in vitro.
Kyung Rok SEUNG ; Hyung Min CHUNG ; Sung Jin HWANG ; In Jae CHO ; Doo Ho KIM ; Hoon Taek LEE ; Kil Saeng CHUNG
Korean Journal of Obstetrics and Gynecology 1993;36(10):3589-3595
No abstract available.
Amniotic Fluid*
;
Animals
;
Embryonic Structures*
;
Female
;
Humans*
;
Mice*
9.Effect of cell-free human amniotic fluid on the develpment of 2-cell stage mouse embryos in vitro.
Kyung Rok SEUNG ; Hyung Min CHUNG ; Sung Jin HWANG ; In Jae CHO ; Doo Ho KIM ; Hoon Taek LEE ; Kil Saeng CHUNG
Korean Journal of Obstetrics and Gynecology 1993;36(10):3589-3595
No abstract available.
Amniotic Fluid*
;
Animals
;
Embryonic Structures*
;
Female
;
Humans*
;
Mice*
10.The Distribution of I/D Polymorphism in the ACE Gene between Korean Young Controls and Athletes.
Jae Koo LEE ; Doo Jin PAIK ; Byung Yong KANG ; Min Hee JANG ; Kang Oh LEE
Korean Journal of Physical Anthropology 2005;18(4):263-270
A number of genetic and environmental factors influence athletic performance. Cardiovascular fitness is an important factor of athletic success, and ACE gene is a good candidate for regulating cardiac and vascular function. Because younger subjects have less chance of being exposed to environmental factors than older ones, genetic factors have a relatively greater influence on younger subjects. The aim of this study was to investigate the distribution of I/D polymorphism in the ACE gene between Korean young controls and athletes. By association study, there were no significant differences in genotype and allele distributions between two groups, respectively (P> 0.05). When stratified by sporting disciplines, the significant difference in distribution was not also detected in our study (P> 0.05). These results do not support the hypothesis that the I/D polymorphism in the ACE gene is associated with endurance performance in Korean young subjects.
Alleles
;
Athletes*
;
Athletic Performance
;
Genotype
;
Humans
;
Sports