1.Dermatofibroma in Patient with Relapsing Primary Cutaneous Anaplastic Large Cell Lymphoma.
Dongyun SHIN ; Do Young KIM ; Min Geol LEE ; Dae Suk KIM
Korean Journal of Dermatology 2015;53(6):482-484
No abstract available.
Histiocytoma, Benign Fibrous*
;
Humans
;
Lymphoma, Large-Cell, Anaplastic
;
Lymphoma, Primary Cutaneous Anaplastic Large Cell*
2.Herpes Simplex Mastitis in a Nonlactating Woman.
Dongyun SHIN ; Do Young KIM ; Min Geol LEE ; Dae Suk KIM
Korean Journal of Dermatology 2014;52(7):519-521
No abstract available.
Female
;
Herpes Simplex*
;
Humans
;
Mastitis*
3.A Case of Segmental Vitiligo with Generalized Morphea Stabilized by Antimalarial Medication.
Hee Jung KIM ; Dongyun SHIN ; Sang Ho OH
Annals of Dermatology 2016;28(2):249-250
No abstract available.
Scleroderma, Localized*
;
Vitiligo*
4.A Case of Segmental Vitiligo with Generalized Morphea Stabilized by Antimalarial Medication.
Hee Jung KIM ; Dongyun SHIN ; Sang Ho OH
Annals of Dermatology 2016;28(2):249-250
No abstract available.
Scleroderma, Localized*
;
Vitiligo*
5.Generalized Pulp Stones of Primary Dentition in a Patient with Molar-Incisor Malformation : A Case Report
Journal of Korean Academy of Pediatric Dentistry 2020;47(3):337-343
Molar-incisor malformation (MIM) is a new type of root anomaly reported recently. The characteristics of MIM are dysplastic root formations, constriction of pulp chambers and presence of calcified matrices at the level of cementoenamel junction in permanent first molars and primary second molars. In some cases, permanent maxillary incisors are also affected. The permanent first molars of the patient in this case report were affected with MIM. Generalized pulp stones were observed in overall primary dentition. Micro-computed tomography (micro-CT) imaging and scanning electron microscope-energy dispersive X-ray spectrometer analysis were performed on the extracted mandibular first molar and maxillary primary second molar of the patient. Micro-CT images revealed the discontinuity of enamel directly connected to an accessory canal of the root.
6.Fluoride Release and Recharge Properties of Several Fluoride-Containing Restorative Materials
Dongyun LEE ; Jongsoo KIM ; Miran HAN ; Jisun SHIN
Journal of Korean Academy of Pediatric Dentistry 2020;47(2):196-204
The aim of the study is to compare the fluoride release and recharge properties of glass ionomer cements and ‘alkasite’.
Specimens of two glass ionomer cements (Fuji Ⅸ GP and Riva Self Cure), ‘alkasite’ restorative material (Cention N) and composite resin (FiltekTM Z350XT) were prepared. The fluoride release of each specimen was measured for 28 days. Thereafter, 1.23% acidulated phosphate fluoride (APF) gel was applied to experimental groups. No treatment was performed on control groups. The fluoride release was measured for additional 7 days to evaluate the fluoride recharge properties of each materials.
The fluoride release was highest in Riva Self Cure, followed by Fuji Ⅸ GP, Cention N (p < 0.05). Fluoride release of Cention N was measured to be approximately 49% of Fuji Ⅸ GP’s. After the application of 1.23% APF gel, increases in fluoride release were observed in Riva Self Cure, Fuji Ⅸ GP and Cention N (p < 0.05). Fluoride recharge was observed in Cention N as well as in glass ionomer cements. Further studies are required to evaluate the anti-cariogenic properties of Cention N at clinical conditions.
7.A New Neolignan Derivative, Balanophonin Isolated from Firmiana simplex Delays the Progress of Neuronal Cell Death by Inhibiting Microglial Activation.
Soo Young LIM ; Lalita SUBEDI ; Dongyun SHIN ; Chung Sub KIM ; Kang Ro LEE ; Sun Yeou KIM
Biomolecules & Therapeutics 2017;25(5):519-527
Excessive activation of microglia causes the continuous production of neurotoxic mediators, which further causes neuron degeneration. Therefore, inhibition of microglial activation is a possible target for the treatment of neurodegenerative disorders. Balanophonin, a natural neolignoid from Firmiana simplex, has been reported to have anti-inflammatory and anti-cancer effects. In this study, we aimed to evaluate the anti-neuroinflammatory effects and mechanism of balanophonin in lipopolysaccharide (LPS)-stimulated BV2 microglia cells. BV2 microglia cells were stimulated with LPS in the presence or absence of balanophonin. The results indicated that balanophonin reduced not only the LPS-mediated TLR4 activation but also the production of inflammatory mediators, such as nitric oxide (NO), prostaglandin E2 (PGE2), Interleukin-1β (IL-1β), and tumor necrosis factor-α (TNF-α), in BV2 cells. Balanophonin also inhibited LPS-induced inducible nitric oxide synthase (iNOS), and cyclooxygenase-2 (COX2) protein expression and mitogen activated protein kinases (MAPKs), including extracellular signal-regulated kinase (ERK1/2), c-Jun N-terminal kinase (JNK), and p38 MAPK. Interestingly, it also inhibited neuronal cell death resulting from LPS-activated microglia by regulating cleaved caspase-3 and poly ADP ribose polymerase (PARP) cleavage in N2a cells. In conclusion, our data indicated that balanophonin may delay the progression of neuronal cell death by inhibiting microglial activation.
Apoptosis
;
Caspase 3
;
Cell Death*
;
Cyclooxygenase 2
;
Dinoprostone
;
JNK Mitogen-Activated Protein Kinases
;
Microglia
;
Mitogen-Activated Protein Kinases
;
Necrosis
;
Nerve Degeneration
;
Neurodegenerative Diseases
;
Neurons*
;
Neuroprotection
;
Nitric Oxide
;
Nitric Oxide Synthase Type II
;
p38 Mitogen-Activated Protein Kinases
;
Phosphotransferases
;
Poly(ADP-ribose) Polymerases
8.Embedded Earring in a 19-year-old Female.
Minseok LEE ; Jimyung SEO ; Dongyun SHIN ; Min Geol LEE ; Dae Suk KIM
Korean Journal of Dermatology 2016;54(5):404-406
No abstract available.
Body Piercing
;
Ear*
;
Female*
;
Humans
;
Young Adult*
9.The Association between Suicidal Ideation, Anxiety, and Sleep Quality Among College Students in a City.
Shin Hyeong KIM ; Chul Soo PARK ; Bong Jo KIM ; Cheol Soon LEE ; Boseok CHA ; Dongyun LEE ; Ji Yeong SEO ; Jae Won CHOI ; In Young AHN ; So Jin LEE
Sleep Medicine and Psychophysiology 2017;24(1):55-61
OBJECTIVES: Suicide is one of the leading causes of death among young adults. We investigated whether anxiety level and sleep quality were related to suicide ideation among university students. METHODS: Questionnaires were distributed to 1094 students at a local college. The scale for suicide Ideation, the Hospital Anxiety-Depression scale, the Pittsburgh Sleep Quality Index, and Morningness-eveningness questionnaires were used. Multiple linear regression analysis was conducted to examine the relationship between these variables and suicide ideation. RESULTS: Among the 292 students who answered the suicide ideation questionnaire, 31 students had a high suicide ideation score and 261 patients had a low suicide ideation score. Demographic variables that showed significant differences between the two groups were gender, exercise, chronotype, sleep quality, depression and anxiety. The results of multiple linear regression analysis showed that suicidal ideation increased as the level of sleep quality decreased. There was no significant relationship between depression and suicidal ideation. Another multiple linear regression analysis was performed to evaluate the relationship between sleep quality sleep related factors. This suggested the quality of sleep decreased as weekend oversleep increased. CONCLUSION: The results of this study showed that when anxiety was higher and the quality of sleep was lower, the more suicide ideation increased. Therefore, improving sleep quality and reducing anxiety are important strategies for reducing suicidal ideation.
Anxiety*
;
Cause of Death
;
Depression
;
Humans
;
Linear Models
;
Suicidal Ideation*
;
Suicide
;
Young Adult
10.Increased Expression of Cathelicidin by Direct Activation of Protease-Activated Receptor 2: Possible Implications on the Pathogenesis of Rosacea.
Ji Young KIM ; Yoon Jee KIM ; Beom Jin LIM ; Hyo Jung SOHN ; Dongyun SHIN ; Sang Ho OH
Yonsei Medical Journal 2014;55(6):1648-1655
PURPOSE: Recent findings of increased cathelicidin protein and its proteolytic fragments in rosacea suggest a pathogenic role for cathelicidin in this disease. The relationship between cathelicidin and protease-activated receptor 2 (PAR-2) is therefore of interest, as PAR-2, expressed principally in keratinocytes, regulates pro-inflammatory cytokine expression in the skin. The purpose of this study was to determine the relationship between expression of PAR-2 and cathelicidin in rosacea and to test the effect of direct PAR-2 activation on cathelicidin expression in keratinocytes. MATERIALS AND METHODS: Samples from 40 patients with clinicopathologic diagnosis of rosacea and facial skin tissue samples from 20 patients with no specific findings or milium without inflammation were retrieved. Intensities of immunohistochemical staining for PAR-2 and cathelicidin were compared between normal and rosacea-affected skin tissues. Additionally, correlations between PAR-2 and cathelicidin staining intensities within rosacea patients were analyzed. In cultured keratinocytes, changes in PAR-2, cathelicidin, and vascular endothelial growth factor (VEGF) mRNA and protein were analyzed after treatment with PAR-2 activating peptide (AP). RESULTS: Cathelicidin expression was significantly higher in rosacea skin tissues than in normal tissues (p<0.001), while PAR-2 expression was not significantly higher in rosacea tissues than in normal skin tissues. A positive correlation between PAR-2 and cathelicidin within rosacea samples was observed (R=0.330, p=0.037). After treatment of PAR-2 AP, both mRNA and protein levels for PAR-2, cathelicidin, and VEGF significantly increased in cultured keratinocytes, compared with PAR-2 control peptide treatment. CONCLUSION: PAR-2 may participate in the pathogenesis of rosacea through activation of cathelicidin LL-37, a mediator of innate immune responses in the skin.
Adult
;
Aged
;
Antimicrobial Cationic Peptides/*metabolism
;
Cytokines/metabolism
;
Female
;
Humans
;
Immunity, Innate
;
Inflammation/metabolism
;
Keratinocytes/*metabolism
;
Male
;
Middle Aged
;
Receptor, PAR-2/*metabolism
;
Rosacea/*pathology
;
Skin/pathology
;
Vascular Endothelial Growth Factor A/*metabolism