Objective To analyze the effect of cyclooxygenase-2（COX-2）on the invasion and metastasis of gastric cancer with Helicobacter pylori（H.pylori）infection.Methods A total of 60 gastric cancer specimens were included in this study.H.pylori infection was deter-mined by improved Giemsa method and the expression of COX-2 was examined by immunohistochemistry.The correlation between H.pylori infection and the clinical pathological features of gastric cancer was analyzed.Results H.pylori infection was detectable in 36 of 60 cases（60.0%）,and correlated with the staging（χ2=28.040,P =0.000）and lymph node metastasis（χ2=25.482,P =0.000）,but not with the age,sex of patients or histological types.H.pylori infection also significantly linked to the expression of COX-2（χ2=24.326,P 〈 0.001）.Con-clusion H.pylori infection may promote the invasion and metastasis of gastric cancer by increasing the expression of COX-2.

Based on the practice of bilingual education in medical biochemistry,this paper discussed the advantages,problems and solutions of bilingual education in medical biochemistry of teaching-centred medical college or university.This study will be helpful for developing bilingual teaching of biochemistry in other teaching-centred medical colleges or universities.