1.Correlation between chemotherapeutic efficacy of paclitaxel and class Ⅲ β-tubulin protein expression in gastric carcinoma patients
Quanliang YANG ; Dongxiang ZENG ; Yongping LIU ; Yang LING ; Huawei JIANG ; Jian MA
Cancer Research and Clinic 2013;(2):94-95,99
Objective To investigate the predictive value of class Ⅲ β-tubulin protein expression in tumor tissue for the efficacy of taxol combined chemotherapy in stage Ⅲ s/Ⅳ gastric carcinoma patients.Methods Tumor biopsy samples were obtained and class Ⅲ β-tubulin protein expression were examined by immunohistochemical staining before chemotherapy.According to different expression of class Ⅲ β-tubulin,the patients were divided into two groups,group A(low expression of class Ⅲ β-tubulin),group B(high expression of class Ⅲ β-tubulin).The patients were assigned to be received 4 to 6 cycles of Taxol and S-1 chemotherapy regimens and followed up until death or lost.Response rate(RR),overall survival(OS)and time to tumor progression(TTP)were assessed.Results There was no significant difference in clinical characteristics among patients with different expression rate.The RR was higher and TIP was longer in group A than in group B(53.3 % vs 36.7 %,198 days vs 146 days,P < 0.05 respectively),and no significant differences of OS in two groups(P > 0.05).Conclusion The expression level of class Ⅲ β-tubulin in tumor tissue is probably a predictor for the efficacy of taxol in gastric cancer patients,taxol combined chemotherapy is more suitable for patients with lower expression of class Ⅲ β-tubulin.
2.Association between XPC and XRCC1 polymorphism and prognosis of primary hepatocellular carcinoma after radical resection
Dongxiang PAN ; Xiaoqiang QIU ; Xiaoyun ZENG ; Shun LIU ; Hua BAI ; Chao TAN ; Hui HUANG
China Oncology 2013;(4):267-272
10.3969/j.issn.1007-3969.2013.04.005
3.A study on creating a promotion index system of medical quality in Grade Ⅲ hospitals in Beijing
Jun LI ; Baoli ZHOU ; Miaorong XIE ; Jiang QIAN ; Yabin YU ; Xiulan LI ; Dongxiang ZHENG ; Xiaoying LI ; Jinsheng ZHANG ; Ying WANG ; Kunling SHEN ; Shengcai HOU ; Xiangmei ZHAO ; Yutong ZHENG ; Yanghai CUI ; Jiang FENG ; Dongguo LIU ; Xiaosong LI ; Yong YAN
Chinese Journal of Hospital Administration 2011;27(4):254-257
To explore how to create and optimize a promotion index system of medical quality evaluation, this article focuses on the hospital visiting process from patients, using analyzing collected those index system from couples of Grade Ⅲ hospitals in Beijing, and combining the results of literal study, field study and specialist consult, according to the different situation of general hospitals and specially hospitals, with the spirit of "maintaining the patients benefits, safeguarding the patients safety,and enhancing the medical quality", introduces the framework of the promotion index system, the rules to select the indicator, and so on, and discusses several problerns related to creating the index system.
4.Analysis of the protection of compensation rights for research participants
Aijuan SHENG ; Xiaoqi WANG ; Liyan SUN ; Dongxiang ZHENG ; Fang LIU
Chinese Medical Ethics 2024;37(5):507-513
Life science and medical research involving human beings cannot be separated from the support of research participants. The safety, health, and rights and interests of research participants are the primary considerations in clinical research, and their rights and interests include the right of compensation, privacy protection, health and so on. Protecting the compensation rights of research participants is a necessary responsibility of the research-related departments and personnel. Based on laws and regulations and literature review, and combined with practical experience, this paper made an in-depth discussion on compensation rights. It puts forward the types of compensation (conventional compensation, research-related damage compensation), compensation principles (necessity, timeliness, appropriateness, fairness), compensation elements (method, amount, plan, consent, notification, and reference of compensation ), compensation under special circumstances (compensation for participants without or with limited informed consent ability and withdraw from the study midway), protection measures of compensation right (sponsor/contract research organizations, research institutions, research management departments, (main) researchers and research teams, ethics (review) committee). The compensation rights should be implemented to protect research participants.
5.Structural optimization and biological evaluation of 1,5-disubstituted pyrazole-3-carboxamines as potent inhibitors of human 5-lipoxygenase.
Yu ZHOU ; Jun LIU ; Mingyue ZHENG ; Shuli ZHENG ; Chunyi JIANG ; Xiaomei ZHOU ; Dong ZHANG ; Jihui ZHAO ; Deju YE ; Mingfang ZHENG ; Hualiang JIANG ; Dongxiang LIU ; Jian CHENG ; Hong LIU
Acta Pharmaceutica Sinica B 2016;6(1):32-45
Human 5-lipoxygenase (5-LOX) is a well-validated drug target and its inhibitors are potential drugs for treating leukotriene-related disorders. Our previous work on structural optimization of the hit compound 2 from our in-house collection identified two lead compounds, 3a and 3b, exhibiting a potent inhibitory profile against 5-LOX with IC50 values less than 1 µmol/L in cell-based assays. Here, we further optimized these compounds to prepare a class of novel pyrazole derivatives by opening the fused-ring system. Several new compounds exhibited more potent inhibitory activity than the lead compounds against 5-LOX. In particular, compound 4e not only suppressed lipopolysaccharide-induced inflammation in brain inflammatory cells and protected neurons from oxidative toxicity, but also significantly decreased infarct damage in a mouse model of cerebral ischemia. Molecular docking analysis further confirmed the consistency of our theoretical results and experimental data. In conclusion, the excellent in vitro and in vivo inhibitory activities of these compounds against 5-LOX suggested that these novel chemical structures have a promising therapeutic potential to treat leukotriene-related disorders.
6.Guidelines for Ethical Review Entrustment Contract of Life Science and Medical Research Involving Humans
Aijuan SHENG ; Meixia WANG ; Qiang LIU ; Zhongguang YU ; Hu CHEN ; Hui JIANG ; Jiyin ZHOU ; Xiaoqi WANG ; Haibin YU ; Mingjie ZI ; Yifeng JIANG ; Lei XU ; Tao SHI ; Guizhen SUN ; Dongxiang ZHENG
Chinese Medical Ethics 2023;36(5):492-498
The passing of ethical review is a necessary conditions and prerequisite for the development of life science and medical research involving humans. At present, some medical and health institutions have no or insufficient ethical review capabilities. The lack of ethical review ability has become a bottleneck restricting the development of life science and medical research involving humans. According to documents such as Opinions on Deepening the Reform of the Review and Approval System and Encouraging the Innovation of Pharmaceutical and Medical Devices, Opinions on Strengthening the Ethical Governance of Science and Technology, institutions can entrust competent institutional ethics review committees or regional ethics review committees in writing to conduct ethical review. Entrustment ethical review provides a viable solution for institutions that need to carry out life science and medical research involving humans but do not have an ethics (review) committee or the ethics (review) committee is not competent to review. To conduct the entrustment ethical review, the entrustment between the principal and the trustee is required. According to The Measures for Ethical Review of Life Sciences and Medical Research Involving Humans, if medical and health institutions and their ethical review committees do not accept the formal entrustment to provide the ethical review opinions for other institutions, the local health authorities at or above the county level will impose administrative penalties and sanctions on the relevant institutions and personnel in accordance with the law. Signing the entrustment ethical review contract, implementing legal compliance entrusted ethical review to protect the rights and interests of the trustee and the principal, and protect the research participants.