Objective To investigate the standard supplement of a certain dose of vitamin D for blood pressure control in pa-tients with essential hypertension.Methods 100 cases of patients with essential hypertension were randomly divided into 2 groups voluntarily,50 cases in each group.One group were set as control group,in which patients underwent a standard treatment.The other group was experimental group,in which 25 μg/d vitamin D was administrated in addition to standard treatment.Serum 25-hydroxyvitamin D[25 (OH)D]concentrations were measured by enzyme-linked immunosorbent assay(ELISA)and patients were followed up for one year to observe the situation of blood pressure controll.Mean and variable coefficient(CV)of systolic and dias-tolic blood pressure were calculated and compared between groups.Results In experiment group,the serum 25 (OH)D concentra-tion was (110.3±24.5)μg/L,systolic pressure was (144±16)mm Hg,variable coefficient of systolic pressure(CV1)was 11.1%, diastolic pressure was (87±9)mm Hg,variable coefficient of diastolic pressure(CV2)was 10.3%.While in control group,the 25 (OH)D concentration was (30.1±14.9)μg/L,systolic pressure was (145 ±26)mm Hg,CV1 was 17.9%,diastolic pressure was (87±10)mm Hg,CV2 was 12.4%.Serum 25(OH)D concentration and CV1 were statistically different between the two groups(P<0.01),CV2 was not statistically different(P >0.05).Conclusion Administrate quantitative vitamin D in addition to standard treat-ment is helpful for systolic pressure control in patients with essential hypertension but is meaningless for diastolic pressure control.

Objective To explore the diagnostic value of β‐human chorionic gonadotropin (β‐HCG) and its free β‐subunit (fβ‐HCG) of adverse pregnancy .Methods Chemiluminescence technique was used for the detection of serum levels ofβ‐HCG ,fβ‐HCG and progesterone in women with early adverse pregnancy (threatened abortion group ,missed abortion group and ectopic pregnancy group) and normal pregnant women (control group) ,respectively .The 48 h doubling rate ofβ‐HCG of each group was calculated . And the results were analyzed .Results Comparing with threatened abortion group ,there were significant differences in the levels of β‐HCG ,fβ‐HCG ,progesterone and doubling rate both of missed abortion group and ectopic pregnancy group (P<0 .05) .How‐ever ,there was no difference in these indicators between missed abortion group and ectopic pregnancy group ( P> 0 .05 ) . Conclusion T he changes of β‐HCG and fβ‐HCG can reflect adverse pregnancy .

Objective To investigate the human chorionic gonadotropin (β-HCG) and its free β-subunit (fβ-HCG) content change,to observe the 48 hours multiplication factor,combined with progesterone value in the diagnosis of adverse pregnancy for clinical diagnosis and treatment of adverse pregnancy to provide guidance.Methods The chemiluminescence technique was used to detect serum β-HCG,fβ-HCG and progesterone levels in early adverse pregnancy.According to pregnancy,the pregnant women were divided into threatened abortion group (65 cases),missed abortion group (43 cases) and ectopic pregnancy group (62 cases),while 60 normal pregnant women were selected as control group.Theβ-HCG,fβ-HCG,progesterone levels and 48 hours multiplication factor were measured.The results combined with the pregnancy outcomes were analyzed.Results The serum β-HCG,fβ-HCG,progesterone levels in the threatened abortion group,missed abortion group and ectopic pregnancy group were (15 385 ± 4 350) IU/L,(77.2 ± 21.3) IU/L,(20.8 ± 6.3) μg/L; (1 584 ± 362) IU/L,(119.3 ± 34.1) IU/L,(6.1 ± 3.7) μg/L; (1 459 ± 493) IU/L,(132.1 ± 35.7) IU/L,(5.7 ± 3.4) μg/L; the β-HCG levels 48 hour doubling rates in three groups were (1.52 ±0.51),(0.21 ±0.26),(0.13 ±0.08) ;threatened abortion group β-HCG and 48 hours multiplication factor,progesterone levels and missed abortion and ectopic pregnancy group were significantly different (t =7.41,5.17,6.89,all P ＜ 0.05) ; there were no significant differences between missed abortion group and ectopic pregnancy group (t =0.851,0.782,0.864,all P ＞ 0.05) ;fβ-HCG in threatened abortion group was average 30mIU/mL lower than the missed abortion group and ectopic pregnancy group,the difference was statistically significant (t =6.18,P ＜ 0.05).With miscarriage success fβ-HCG showed a decreasing trend.Conclusion β-HCG and progesterone combined 48 hours multiphcation ratio values for monitoring miscarriage of important guiding significance for the diagnosis of missed abortion and ectopic pregnancy has important reference value trimester β-HCG 48 hour doubling rate of less than 0.5,abortion increased risk;fβ-HCG data descending indicates miscarriage treatment is effective.

Objective To investigate the effect of controlling blood pressure in treating patients with hypertension by taking quantitative vitamin D to provide support for the clinical treatment of patients with hypertension.Methods 100 cases with hypertension were randomly divided into the two groups voluntarily,50 cases in each group and one group with a simple standard treatment was considered as the control group,and the other one was the study group,25μg/d vitamin D was taken besides standard treatment.Each group content of 25-hydroxyvitamin D [25 (OH)D] level were measured by Enzyme-linked immunosorbent assay (ELISA) and lasted for one year to detect the situation of controlling blood.Mean and variable coefficient of systolic and diastolic blood pressure were calculated and compared each other.Results After treatment,the content level of 25 (OH)D was (110.3 ± 24.5)nmol/L,systolic pressure was (144 ± 16) mmHg,variable coefficient was 11.1％,diastolic pressure was (87 ± 9) mmHg,variable coefficient was 10.3％ in experiment group;while the content of level of 25 (OH)D was (30.1 ± 14.9)mol/L,systolic pressure was (145 ± 26)mmHg,variable coefficient was 17.9％,diastolic pressure was (87 ± 10)mmHg,variable coefficient was 12.4％ ;the content of level of 25 (OH)D,variable coefficient of systolic pressure had statistical difference (t =12.47,x2 =6.72,P ＜ 0.01),variable coefficient of diastolic pressure had no statistical difference (P ＞ 0.05).Conclusion Taking quantitative vitamin D besides standard treatment is benefit for controlling the level of systolic pressure in patients with hypertension but is meaningless to the level of diastolic pressure.