1.The Distribution of Ammonia Nitrogen in Groundwater of Shunyi and Its Influencing Factors
Yutang LI ; Guoxin ZHEN ; Dongwan CHEN
Journal of Environment and Health 2007;0(09):-
Objective To discover the distribution of ammonia nitrogen in groundwater of Shunyi District and its influencing factors. Methods 286 monitored points in low-flow period and 100 in high-flow period were chosen in 19 towns in Shunyi District. Concentrations of ammonia nitrogen, iron and manganese, and the total bacterial count of water samples were determined and evaluated based on the Guidelines for Drinking Water Quality and related standard during Jan.-Mar., Aug.-Sep., in 2005. Results All the monitored points were deep groundwater. The median of ammonia nitrogen concentration in groundwater was 0.010 mg/L in low-flow period, and 0.140 mg/L in high-flow period. The relativity was not found between the concentration of ammonia nitrogen,total bacterial count in water sample and pollution source around the well. However the concentration of ammonia nitrogen was positively correlated with the concentration of nitrite nitrogen(r=0.224, P
2.Chronic hypoperfusion due to intracranial large artery stenosis is not associated with cerebral β-amyloid deposition and brain atrophy.
Dongyu FAN ; Huiyun LI ; Dongwan CHEN ; Yang CHEN ; Xu YI ; Heng YANG ; Qianqian SHI ; Fangyang JIAO ; Yi TANG ; Qiming LI ; Fangyang WANG ; Shunan WANG ; Rongbing JIN ; Fan ZENG ; Yanjiang WANG
Chinese Medical Journal 2022;135(5):591-597
BACKGROUND:
Insufficient cerebral perfusion is suggested to play a role in the development of Alzheimer disease (AD). However, there is a lack of direct evidence indicating whether hypoperfusion causes or aggravates AD pathology. We investigated the effect of chronic cerebral hypoperfusion on AD-related pathology in humans.
METHODS:
We enrolled a group of cognitively normal patients (median age: 64 years) with unilateral chronic cerebral hypoperfusion. Regions of interest with the most pronounced hypoperfusion changes were chosen in the hypoperfused region and were then mirrored in the contralateral hemisphere to create a control region with normal perfusion. 11C-Pittsburgh compound-positron emission tomography standard uptake ratios and brain atrophy indices were calculated from the computed tomography images of each patient.
RESULTS:
The median age of the 10 participants, consisting of 4 males and 6 females, was 64 years (47-76 years). We found that there were no differences in standard uptake ratios of the cortex (volume of interest [VOI]: P = 0.721, region of interest [ROI]: P = 0.241) and grey/white ratio (VOI: P = 0.333, ROI: P = 0.445) and brain atrophy indices (Bicaudate, Bifrontal, Evans, Cella, Cella media, and Ventricular index, P > 0.05) between the hypoperfused regions and contralateral normally perfused regions in patients with unilateral chronic cerebral hypoperfusion.
CONCLUSION
Our findings suggest that chronic hypoperfusion due to large vessel stenosis may not directly induce cerebral β-amyloid deposition and neurodegeneration in humans.
Aged
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Alzheimer Disease/pathology*
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Amyloid beta-Peptides/metabolism*
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Arteries
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Atrophy
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Brain/metabolism*
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Cerebral Cortex/metabolism*
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Cerebrovascular Circulation
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Constriction, Pathologic/pathology*
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Female
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Humans
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Magnetic Resonance Imaging/methods*
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Male
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Middle Aged
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Positron-Emission Tomography/methods*