1. Correlation between severity of gastroesophageal reflux cough and degree of gastroesophageal reflux disease
Suping TANG ; Yanlin LIU ; Hong GAO ; Li DONG ; Dongru LIN ; Shen CHEN ; Danyun ZHANG ; Lingling ZHANG ; Juan PAN
Chinese Journal of Pediatrics 2018;56(7):534-538
Objective:
To explore the correlation between the severity of gastroesophageal reflux cough and degree of gastroesophageal reflux.
Methods:
A cross-sectional investigation was carried out. Data of 174 cases of chronic cough were collected in Children's Hospital of Fuzhou from March 2009 to December 2016. The esophageal 24 hours pH value dynamic monitoring was used to detect gastric acid reflux index. Cases with abnomal results were divided into mild, moderate and severe groups according to severity of reflux and that of day and night cough symptoms, respectively. They were also divided into infant (1-3 years old), preschool (4-6 years old), and school age (>7 years old) groups according to age. Comparative analysis between groups by chi-square test and rank sum test were performed. Correlation analysis was used to analyze the correlation between cough severity and gastroesophageal reflux index.
Results:
A total of 174 patients with chronic cough, including 115 males and 59 females, aged from 1 to 15 years with an average age of (8.5±2.3) years, and (1.6±0.8) years of disease duration were enrolled. Among them, 129 cases (74.1%) were positive for esophageal reflux test and 45 cases (25.9%) with no obvious pathological gastroesophageal reflux. Patients with positive esophageal reflux test were divided into severe (