1.The surgical experience of the recurrent hepatolithiasis of 163 cases
Chinese Journal of Postgraduates of Medicine 2008;31(12):12-14
Objective To study the ways and effect of surgical treatment for recurrent hepatolithiasis. Methods The therapeutic patterns and the clinical effect were retrospectively analyzed for 163 patiens8 with recurrent hepatolithiasis from January 2004 to December 2006.The 86 patients were partical hepatectomy, the 77 patients were no hepatectomy. Results The excellent rate was 96.5%,the incidence of residual stone and recurrence was 5.8%and 1.2%respectively in partical hepatectomy-but 85.7%,15.6% and 11.7%in no hepatectomy. There were statistical significance between the partical hepatectomy and no hepatectomy(P<0.05).Conclusion The therapeutic effect of the partial hepatectomy is better than that of the nohepatectomy for the patients with gallstone.
2.Clinical analysis on primary small intestinal tumor
Jinxue TONG ; Yuanlian WAN ; Dongmin WANG
Chinese Journal of General Surgery 2000;0(12):-
ObjectiveTo explore the clinical characteristics and diagnosis of primary small intestinal tumor (PSIT). MethodsRetrospective analysis of the clinical and pathological data of the 112 PSIT cases was made. ResultsDuodenum was the most common site for PSIT (62 5%). Leiomyomas were most common benign tumors which were most likely found in ileum and jejunum. Adenocarcinoma was the most frequently seen malignant PSIT followed by lymphoma and leiomyosacroma. The chief method of diagnosis is barium meal X ray examination especially with the hypotonic contrast X ray examination. Endoscopy can increase the diagnostic rate. Superior mesenteric arteriography sometimes helps in determing the site of gastrointestinal haemorrhage. CT scan can be helpful in establishing diagnosis, preoperative classification and postoperative recurrences. Conclusion Duodenal adenocarcinoma is most common PSIT, followed by malignant lymphoma, liomyoma and leiomyosarcoma. Hypotonic contrast X ray examination is most effective in diagnosis, and locating of small bowel tumors. Superior mesenteric artery angiography and CT scanning are also helpful.
3.Diagnosis and Operative Treatment of Spinal Tumor
Dongmin XIAO ; Wangchun WANG ; Jiangdong NI
Journal of Chinese Physician 2001;0(05):-
Objective To explore the diagnosis and operative treatment of spinal tumor. Methods Clinical symptom, diagnosis and operative treatment of 22 patients with spinal tumor in our institution from August 1987 to August 2002 were analysed retrospectively. Results Combining with patients' clinical symptoms and results of corresponding examination, all cases were diagnosed before operation. After operation, all the patients recovered with different outcome except 3 patients died. There were 18 cases nearly cured. Conclusion The clinical symptoms of the patients with spinal tumor have some specialty. The preoperative diagnosis mainly depends on MRI. The various operative modes should be taken according to tumor localization.
4.DISCRETE RADIOFREQUENCY CATHETER ABLATION FOR PAROXYSMAL ATRIAL FIBRILLATION IN A DOG MODEL
Yanping ZHENG ; Jinzhi FENG ; Dongmin WANG
Medical Journal of Chinese People's Liberation Army 2001;0(11):-
To investigate an approach of treatment for atrial fibrillation with discrete ablation lesion, 12 dogs with experimental atrial fibrillation underwent radiofrequency catheter ablation. Atrial lesion was made at the most vulnerable site. The results showed that in 10 of 12 dogs persistent fibrillation could be ablated. There was no significant change in sinus heart rate, P wave duration, and corrected sinoatrial node recovery time (cSNRT). The results suggested that paroxysmal atrial fibrillation could be eliminated by point ablation of the lesion, and that trigger activity might be involved in the mechanism of atrial fibrillation.
5.Inhibitory effects of lobaplatin on human ovarian cancer and its regulation of apoptosis-related genes in nude mice
Dongmin WEI ; Hongyan YU ; Hui WANG ; Wenli LIU ; Sufang SHI
Journal of Chinese Physician 2015;17(1):81-83
Objective To explore the inhibitory effects of lobaplatin and cisplatin and their regulation of apoptosis-related genes in ovarian cancer cells in nude mice.Methods SKOV3 cells were implanted into nude mice.In monotherapy treatment study,the nude mice bearing human SKOV3 cells were randomly divided into control,lobaplatin,and cisplatin groups,with 7 mice in each group.The mice in each group were received corresponding treatment.The volume of tumor and the weight of nude mice were measured three times per week,respectively.Tumor inhibitory rate was calculated.The protein expressions of bax and bcl-2 were detected by flow cytometry.Results The growth inhibitory rate was 47.2% in lobaplatin group and 42.8% in cisplatin group,without significant difference between two groups (P > 0.05).The expression of bcl-2 was decreased but the bax was increased in lobaplatin and ciaplatin groups compared to the control group.Conclusions Lobaplatin can significantly inhibit the growth of ovarian cancer cells,induce apoptosis by down-regulation of bcl-2 and up-regulation of bax.
6.Selection of antigen retrieval methods in immunohistochemical staining of nuclear receptors
Fujun ZHANG ; Juan REN ; Feimiao WANG ; Shemin Lü ; Dongmin LI
Journal of Xi'an Jiaotong University(Medical Sciences) 2010;31(2):252-254
Objective To explore the effects of different methods of antigen retrieval on the results of immunohistochemical staining of nuclear receptors. Methods Antigens were retrieved by using microwave oven, autoclave, enzyme and autoclave plus enzyme, respectively, in liver sections from DA.1U rats, followed by immunohistochemical staining. Results After antigen retrieval with autoclave, the positive staining intensity of nuclear receptors LXR-α, LXR-β, PPAR-γ and FXR in the liver sections from DA.1U rats was enhanced obviously, and the location of nuclear receptors was better by using this method than the others. Conclusion In the immunohistochemical staining of nuclear receptors, using autoclave to retrieve antigens is the best method.
7.Clinical observation of valsartan in combination with amlodipine in therapy of essential hypertension together with the impact on red cell distribution width
Deyong HU ; Jiashuai WANG ; Dan HE ; Guomiao LI ; Dongmin SHAO
Chinese Journal of Postgraduates of Medicine 2012;(z2):32-35
Objective To observe the therapeutic effectiveness of valsartan in combination with amlodipine in therapy of essential hypertension and the consequent changes in red cell distribution width (RDW).Methods One hundred and ten patients of hypertension were selected,then randomly divided into treatment group (56 cases) and control group (54 cases).Valsartan and amlodipine were given to the treatment group,while the control group taking amlodipine only.Bp and RBC were carried out before and after treatment.Results Antihypertensive effect of the treatment group were statistically significant compared with the control group (P < 0.05).The consequent RBC,Hct and Hb,RDW level of treatment group decreased dramatically compared with the control group (P < 0.01 or < 0.05).Conclusions Valsartan in combination with amlodipine in ther apy of hypertension is a prospective combination which achieves superior blood pressure control,low level of RDW and blood viscosity,as a result reducing the incidence of cardiovascular events.
8.Ultrasound detection of fetal ductus arteriosus
Fengqun DONG ; Yanhong ZHANG ; Dongmin LU ; Xinjian HE ; Yazhou GUO ; Kun WANG
Chinese Journal of Ultrasonography 2011;20(1):49-52
Objective To explor the ultrasonography methodology of the fetal ductus arteriosus.Methods Based on the fetal four-chamber sight, the characteristic ultrasound images were observed by moving probe,such as "V-shape" sign,"three-finger" sign,"Z-shape" sign and"hockey-handle" sign making up of the ductus arteriosus and the nearby structures were observed by moving probe. The inner diameter,the systole flow velocity,the diastole flow velocity and the resistance index of the ductus arteriosus via the "V-shape" sign section were measured. Results Among the 365 normal fetus cases,355 "V-shape" sign cases,237 "three-finger" sign cases,298 "Z-shape" sign cases and 331 "hockey-handle" sign cases were identified. The inner diameter of the fetal ductus arteriosus increases gradually with the growth of the gestational weeks and the flow velocity increases gradually too, while the resistance index had no obvious variation with the growth of the gestational weeks. Conclusions According to the characteristic ultrasound images, such as "V-shape" sign, "three-finger" sign, "Z-shape" sign and "hockey-handle" sign, the fetal ductus arteriosus can be identified promptly.
9.Analysis of prostatic fluid cytology in patients with elevated PSA
Xin CHEN ; Yuefeng LI ; Ping WANG ; Dongmin YUE ; Qing YE ; Zhuo YANG ; Weiqing ZANG ; Guanghao WANG ; Xiaoguang QU ; Fujin GAO
Chinese Journal of Urology 2012;33(2):123-126
ObjectiveTo study the value of the exfoliative cytology of prostatic fluid obtained from patients with elevated PSA in prostate cancer diagnosis.MethodsProstatic fluid was obtained from 130 patients with elevated PSA before prostate biopsy and then the Wright's stain and cytological class were done.Each cytological class and patient's age,PSA,total prostate volume,prostatic fluid volume and the number of leukocyte in the prostatic fluid were recorded.The relationship of leukocyte number and patient's age,PSA and prostate volume was analyzed by Spearman correlation test.ResultsProstate biopsy pathology results showed that there were 77 (59.2%) cancer cases and 53 (40.8%) non-cancer cases.Patient numbers in cytological class 1 to 5 were 28 (21.5%),32 (24.6%),22 (16.9%),36 (27.7%),12(9.2%),respectively.The prostate fluid cytology had a specificity of 100% and high sensitivity of 62.5%(10/16) in patients with PSA≥20 μg/L.PSA value had significant difference between class 1,2,3,4and 5.Significant correlation was found among the prostatic fluid volume,total leukocyte number and prostate volume.Prostate volume,leukycyte density and total leukycyte number was significant higher in noncancer patients than in prostate cancer patients.ConclusionsThe exfoliative cytology of prostatic fluid is a valuable method in detecting prostate cancer,particularly in patients with high PSA levels.It has the advantages of non-invasion and less injury than prostate biopsy.There is a relationship between elevated PSA value and high leukocyte numbers.
10.A study on syphilis and HSV-2 infection and related behaviors among female sex workers who take new types of drugs in Jiaozhou city.
Zheng LI ; Dongmin LI ; Zhenxia JIANG ; Huixin LIU ; Ning WANG
Chinese Journal of Preventive Medicine 2014;48(10):857-861
OBJECTIVETo explore the prevalence of syphilis and HSV-2 among female sex workers (FSWs) who use new types of drugs in Jiaozhou city.
METHODSThrough convenient sampling, an anonymous questionnaire survey was conducted among female sex workers to collect demographic characteristics, new-type drugs abusing characteristics and related sexual behaviors from October to December, 2013. Blood specimens were drawn for serological tests of syphilis antibody and HSV-2 antibody. Urine specimens of the subjects surveyed were collected to test for methamphetamine. Differences in demographic characteristics, new-type drug abusing characteristics, and sexual behaviours between drug-abusing FSWs and non-drug-abusing FSWs were compared by t-test and χ(2)-test.
RESULTSA total of 460 FSWs were recruited in this study, and 105 FSWs admitted their drug abuse history. Among the 341 urine specimens confirmed to be methamphetamine positive, there were 3 FSWs claimed that they never abuse new-type drugs. The rate of new-type drug abuse was 23.5% (108/460). A total of 71.4% (75/105) of the new drug-abusing FSWs started using drugs under 25 years old. The main reasons for drug abuse were clients request (24, 22.9%), making more money (23, 21.9%) and companion temptations (22, 21.0%). Totally, 41.9% of them (44/105) took drugs with 4-5 persons, 32.4% (34/105) had sex with 2-3 men after taking drugs, and 60.2% of new-type drug-abusing FSWs (65/108) used condoms in the latest commercial intercourse, while only 7.4% FSWs (8/108) used condoms every time during their commercial sex activities in the recent month. Compared with FSWs having no drug abuse behavior, drug-abusing FSWs had higher single proportion (73.2% (79/108) vs 63.6% (224/352), χ(2) = 8.64, P < 0.05), lower condom use rate in the recent month (7.4% (8/108) vs 22.7% (80/352), χ(2) = 12.53, P < 0.01) and higher pregnancy rate in the recent 6 months (24.1% (26/108) vs 8.8% (31/352), χ(2) = 17.74, P < 0.01) and most of them come from the middle and high-level entertainmens (78.7% (85/108) vs 65.1% (229/352), χ(2) = 13.09, P < 0.01). Among the new-type drug-abusing FSWs, the prevalence rates of syphilis and HSV-2 were 12.0% (13/108) and 55.6% (60/108) , respectively. A total of 33 FSWs claimed that they were diagnosed with STDs in the recent year (30.6%) . The rates of syphilis(12.0% (13/108) vs 4.0% (14/352), χ(2) = 9.72, P < 0.01), HSV-2(55.6% (60/108) vs 39.2% (138/352), χ(2) = 9.01, P < 0.01) and diagnosed STDs (30.6% (33/108) vs 17.9% (63/352), χ(2) = 8.02, P < 0.01) among the drug-abusing FSWs were significantly higher than those of non-drug-abusing FSWs.
CONCLUSIONThere is a higher proportion of new-type drug abuse among the FSWs in Jiaozhou, with significantly higher prevalence rates of syphilis and HSV-2 infection, compared with non-new types of drug abusing FSWs. Prevalent risk sexual behaviors and ignorance of new-types drugs' harm were seen among them.
China ; epidemiology ; Condoms ; Designer Drugs ; Female ; Herpes Genitalis ; epidemiology ; Herpesvirus 2, Human ; Humans ; Methamphetamine ; Pregnancy ; Prevalence ; Risk Factors ; Risk-Taking ; Sex Work ; Sex Workers ; statistics & numerical data ; Sexual Behavior ; drug effects ; statistics & numerical data ; Sexual Partners ; Substance-Related Disorders ; Syphilis ; epidemiology