Objective To investigate the clinical characteristics of upper respiratory tract infection in hospita-lized children with mental disorders,and to analyze the risk factors for nosocomial infection,so as to provide reference for clinical treatment and prevention and control of nosocomial infection(NI). Methods The NI of 1 587 hospitalized children at the Second Affiliated Hospital of xinxiang Medical University from January to December 2016 was investiga-ted and a retrospective study was conducted on 78 hospitalized children with nosocomial upper respiratory tract infec-tion. In a ratio of 1: 2,the patients with mental disorders during the same time at hospital,without the occurrence of hospital infection,with same gender and same age group,were selected as the control group,then the univariate regres-sion analysis and multivariate conditional Logistic regression analysis were carried out. Results Of the 1 587 cases,86 cases were NI,and the incidence of NI infection was 5. 42%. Among them,the upper respiratory tract infection accoun-ted for 83. 87%(78 cases). Univariate conditional Logistic regression analysis indicated that the type of disease,hospi-talization days,insight,rehabilitation activities,hand hygiene habits,self -support ability,eating habits,management mode,seasonal and environmental conditions were the risk factors for upper respiratory tract infection in hospitalized children with mental disorders(all P<0. 05). Multivariate analysis showed that the odds ratio( OR)of autumn and winter,poor self-support ability,no insight,poor hand hygiene habits,longer hospitalization days( over 14 d),severe mental illness were 19. 627( 5. 391 -23. 518 ),12. 835( 3. 436 -18. 715 ),5. 427( 1. 879 -16. 921 ),3. 752 (1. 743-16. 864),3. 618( 1. 659 -12. 671 ),3. 361( 1. 478 -10. 527 ),respectively,which were significantly associated with the occurrence of upper respiratory infection,and the differences were statistically significant( all P<0. 05). Conclusions The season,self-support ability,insight,hand hygiene habits,days hospitalization,and disease type are the independent risk factors for upper respiratory infection in hospitalized children with mental disorders,posi-tively controlling and eliminating of independent risk factors for upper respiratory tract may reduce its incidence in the inpationt children.