OBJECTIVE:To make clear the market situation of anti-infectives which occupies an important place in drugs used in hospitals in China.METHODS:To analyse the market scale and developmental tendency of anti-infectives.RESULTS&CONCLUSION:Now,promoting and suppressing factors affecting the market expansion exist side by side in China.The charac?teristic of market is in absolute expansion of scale,and some drugs,such as cephalosporins,hold the major share of market.The increasing speed of market demand is slowing down year by year.

OBJECTIVE:To discuss about the strategy of technology advancement in pharmaceutical industry of Chi?na.METHODS:According to the analysis of comparative advantages of chemical pharmaceutical industry and industry of Chi?nese materia medica,the different competitive status of them was made definite.RESULTS&CONCLUSION:In the inter?national competition,Chinese traditional materia medica has distinctive advantage,while the chemical pharmaceutical industry lags behind,therefore the innovation strategy should be different between them.

OBJECTIVE: To discuss about the acceptability of the structural convergence of regional pharmaceutical indus- try. METHODS: According to the calculation of LQ and LQS2, the regional distributing structure of pharmaceutical industry was judged. RESULTS & CONCLUSION: The results showed that the regional distribution of pharmaceutical industry in China assumed characteristics of regional convergence. Because advanced technology and large scale are very important to pharmaceutical industry, the structural convergence of regional pharmaceutical industry is not acceptable.

Coronary heart disease and depression have a close relationship.Depression is common in patients with coronary artery disease and its presence is a strong independent risk factor for the development and adverse prognosis of coronary heart disease.The present review has summarized current knowledge of depression in patients with coronary artery disease regarding epidemiology,pathophysiologic pathways and treatment.

OBJECTIVE: To discuss about the strategy of small and medium-sized pharmaceutical enterprises' development.METHODS: According to the analysis of different kinds of small and medium-sized pharmaceutical enterprises and the discussion of competition strategy, this paper brings forward the successful development model of small and medium-sized pharmaceutical enterprises.RESULTS & CONCLUSION: Small and medium-sized pharmaceutical enterprise advanced in technology is a successful development model in future. In order to get the development of this kind of enterprise, we should adjust our tactis in aspects of enterprise and goverment.

OBJECTIVE: To provide references for the improvement of drug safety of emergent public health events.METHODS: The characteristics of drug demands in emergent public health events were analyzed to guarantee the characteristics of drug safety so as to explore effective safeguard strategy.RESULTS & CONCLUSIONS: Special system and countermeasure are required to guarantee drug safety of emergent public health events.The strategy includes three aspects,i.e.adequate plan in advance,rapid response and timely consummation after the event.

OBJECTIVE: To discuss about the strategy of small and medium - sized pharmaceutical enterprises' develop-ment .METHODS: According to the analysis of different kinds of small and medium - sized pharmaceutical enterprises and the discussion of competition strategy, this paper brings forward the successful development model of small and medium - sized pharmaceutical enterprises.RESULTS & CONCLUSION: Small and medium - sized pharmaceutical enterprise advanced in technology is a successful development model in future. In order to get the development of this kind of enterprise, we should adjust our tactis in aspects of enterprise and goverment.

Recently numerous studies have demonstrated that Notch signaling pathway plays a critical role in regulating cell proliferation and differentiation in hematopoietic microenvironment,which is associated with MM occurrence and the drug resistance.The latest researches show that there are close relations between hypoxia and Notch signaling pathway in tumor occurrence and progression.Exploring the interactions of microenvironment of hypoxia,HIF-1α and Notch signaling pathway will provide theoretical basis for MM targeted therapy.

Objective To investigate the breeding densities and the seasonal distribution of Tyrophagus putrescentiae, Acarus siro, Lepidoglyphus destructor, and Dermatophagoides farinae in Bengbu City, 4 common storage acaroid mites during Feb.2006-Jan.2007. Methods The samples were collected and isolated by Waterflotation and Tullgren, then counted and identified the four acaroid mites from 20 different habitats. Results 4 species of acaroid mites had high breeding density in ham, wheat, seed and house dust. The number of the mite increased from Apr. or May, and to the peak during July and Aug. and declined from Sep. or Oct.. Seasonal distribution of the individual acaroid mites might be different. Conclusion 4 species of acaroid mites are widely distributed in Bengbu city with distinctive seasonal distribution.

Objective To investigate and report the catalogue and distribution of acaroid mites in region of Jianghuai.Methods The dust samples were collected from storage circumstances, working places and human dwellings from Jianghuai region(11 cities) in Anhui province from April to October, 2006.Acaroid mites were isolated by waterflotation and tullgren, then counted and identified.Results Thirty species of acaroid mites were identified, belonging to 20 genera, 7 families(4 subfamilies), the dominant species were Tyrophagus putrescentiae, Acarus siro, Lepidoglyphus destructor, Glycyphagus domesticus, Dermatophagoides farinae and Dermatophagoides pteronyssinus.Conclusion Acaroid mites breeding in differenai habitats of Jianghui region distributes widely and shows significant diversity.