Objective To study the effect of nursing intervention for elderly patients with chronic obstructive pulmonary disease with oxygen treatment.Methods A total of 125 elderly obstructive pulmonary disease(COPD) patients with different nursing methods in our hospital were divided into observation group and control group.After given corresponding nursing care, patients''satisfaction of two groups were evaluated, and relevant influencing factors was analyzed.Results Nursing satisfaction in the observation group was obviously higher than that of the control group;Course of the disease, complications, bad feelings, and mechanical damage were influencing factors of oxygen efficacy for elderly patients with chronic obstructive pulmonary disease.Conclusion Nursing intervention can improve oxygen effect for senile chronic obstructive pulmonary disease patients, and improve quality of life, and correct cognition and compliance of patients.

Objective To study the effect of nursing intervention for elderly patients with chronic obstructive pulmonary disease with oxygen treatment.Methods A total of 125 elderly obstructive pulmonary disease(COPD) patients with different nursing methods in our hospital were divided into observation group and control group.After given corresponding nursing care, patients''satisfaction of two groups were evaluated, and relevant influencing factors was analyzed.Results Nursing satisfaction in the observation group was obviously higher than that of the control group;Course of the disease, complications, bad feelings, and mechanical damage were influencing factors of oxygen efficacy for elderly patients with chronic obstructive pulmonary disease.Conclusion Nursing intervention can improve oxygen effect for senile chronic obstructive pulmonary disease patients, and improve quality of life, and correct cognition and compliance of patients.

Objective To test the effect of an APP in the adherence of inhalation medicines for children with asthma,improve the rate of inhalation medicines compliance,self management ability and the quality of life of children with asthma.Methods The research use self-control study.We use Medication Adherence Report Scale for Asthma (MARS-A) to test the adherence of inhalation medicines for children with asthma in outpatient department.After 2 months using the APP,the children with asthma may be re-tested by the MARS-A to compare the differences in medication adherence,asthma knowledge,use method and pulmonary function,etc.Finally,data analysis using paired t test.Results After using the APP,the inhalation medicines adherence rate is increased from 25.78 ％ to 68.75 ％,the awareness rate of patients and their caregivers are increased from 25 ％ to 65 ％,and the APP usage rate is 42.18％,there was significant difference (P＜0.01).Conclusion The APP can effectively improve the adherence of inhalation drugs,standardized medication management,guarantee treatment effect and improve the quality of life of children with asthma.It could also reducing medical costs and improving work efficiency and service quality,thus deserves promotion.

Objective To establish a fluorescent quantitative one step real time-PCR method for the detection of GIV NoVs.Methods Specific primers and TaqMan probe of GIV NoVs were analysed and synthesized.Then the reaction system and conditions were optimized and the RNA standard was conducted according to the sequence of human GIV NoVs of our nation.The sensitivity,specificity,and repeatability of this method were evaluated,and the traditional RT-PCR method was used to assess the method.Results The sensitivity of this method reached 1.0 × 102 copies/μl,and the detection range was 102 ～ 108copies/μl.No cross reaction with NoVs (GⅠ,GⅡ),enteric adenovirus,rotavirus,astrovirus and others was found,showing high specificity.By repeated experiments,the intra-assay and inter-assay coefficient of variation (CV) about Ct value was less than 1.31％ and 3.68％ respectively,which showed good repeatability.The method has high sensitivity and accurate quantity advantage by comparison with the traditional RT-PCR on detection of positive samples.Conslusions The developed fluorescent quantitative one step real time PCR method for identification of the GIV NoVs will be applied to detecting GIV NoVs in gastroenteritis patients.

Objective:To explore the correlation between time in range (TIR) after short-term treatment and glycated hemoglobin after 3 months (HbA lc-3m) in patients with newly-diagnosed type 2 diabetes mellitus (T2DM). Methods:In this cross-sectional study, a total of 94 patients with newly-diagnosed T2DM who received treatment in the Department of Endocrinology of Inner Mongolia Autonomous Region People′s Hospital were enrolled from January 2018 to September 2022. The patients were followed-up for 3 months and had complete medical record. TIR was divided into three groups according to different target ranges of blood glucose (TIR1: TIR with blood glucose between 3.9 and 10.0 mmol/L, TIR2: TIR with blood glucose between 3.9 and 7.8 mmol/L, TIR3: TIR with fasting, premeal or bedtime blood glucose <6.1 mmol/L and 2 h postprandial blood glucose <8.0 mmol/L). The patients were divided into two groups based on whether their HbA 1c-3m level was less than 6.5%, and the baseline data and variations in TIR for distinct target glucose levels were compared between the two groups. Spearman′s correlation analysis and binary logistic regression analysis were used to analyze the relationship between baseline indicators, TIR after short-term treatment and HbA 1c-3m. Receiver operating characteristic curve (ROC) was drawn to evaluate the predictive ability of different TIR after short-term therapy for HbA 1c-3m. Results:There were statistically significant differences in TIR1 [81.0 (67.5, 94.6)% vs 71.4 (51.7, 85.7)%], TIR2 [57.7 (29.7, 70.8)% vs 40.9 (22.4, 52.3)%] and TIR3 [23.8 (10.2, 39.5)% vs 13.0 (4.8, 25.0)%] between patients with a HbA 1c-3m<6.5% and patients with a HbA 1c-3m≥6.5% (all P<0.05). Spearman correlation analysis showed that among all the patients with newly-diagnosed T2DM, TIR1, TIR2 and TIR3 were all negatively correlated with HbA 1c-3m [6.4 (6.1, 6.9)%] ( r=-0.322, -0.348, -0.303, respectively, all P<0.01). Logistic regression analysis showed that after adjusting for the confounding factors, TIR1 ( OR=1.021, 95% CI: 1.002-1.041; P=0.034), TIR2 ( OR=1.024, 95% CI: 1.006-1.043; P=0.011), TIR3 ( OR=1.037, 95% CI: 1.010-1.065; P=0.008) were all independently related to HbA 1c-3m. When HbA lc-3m<6.5% was taken as the target value, the area under the ROC curve: TIR1 was 0.639 (95% CI: 0.528-0.751), TIR2 was 0.671 (95% CI: 0.560-0.782), TIR3 was 0.659 (95% CI: 0.549-0.770), respectively. When HbA lc-3m<7.0% was taken as the target value, the area under the ROC curve: TIR1 was 0. 730 (95% CI: 0.619-0.841), TIR2 was 0.744 (95% CI: 0.642-0.846), TIR3 was 0.701 (95% CI: 0.588-0.814). There was no significant difference in the area among the three statistics ( P>0.05). Conclusions:For newly-diagnosed T2DM patients, TIR after short-term treatment is negatively correlated with HbA 1c after 3 months and has good predictive value for it.