Objective:To construct a new home nursing service model based on information platform grid management, in order to effectively solve the medical care needs of home rehabilitation groups.Methods:In November 2018, Taizhou City, Zhejiang Province established the Municipal Home Care Service Center and Home Rehabilitation Nursing Skills Training Center, and established a gridding home nursing service model, and implemented the sinking of high-quality nursing resources, and made community nurses the main force of home care. In November 2019, a home nursing service information platform was established to create an online and offline integrated home nursing grading management system. The high quality, convenience and safety of home nursing services was ensured through information sharing and graded orders. We recorded the development of gridding home nursing services and patient satisfaction from January to May 2020, and evaluated the implementation effects. χ 2 test was used for statistical analysis. Results:Totals of 28 hospitals above ClassⅡ, 123 primary medical institutions, and 1 171 community nurses in Taizhou have settled on the home nursing information platform. From January to May 2020, nursing staff provided 5 274 cases of home care, including 4 472 cases of home care and 802 cases of online care. The patient satisfaction of home care was 98.73% (4 415/4 472) , and the patient satisfaction of online care was 98.25% (788/802) , there was no significant difference between the satisfaction of two service types (χ 2=1.136, P=0.286) . No complaints, adverse events and nurse safety issues occurred. Conclusions:The gridding home nursing service model based on information platform can give full play to the role of community nurses, broaden the scope of home care services, rationally allocate medical resources, solve medical care problems for home rehabilitation groups, and effectively promote hierarchical diagnosis and treatment.

Objective To explore the effect of pain management model of the nurse-centered multidisciplinary cooperation on quick recovery in lung cancer patients with video-assisted thoracoscopic surgery vats (VATS).Methods A total of 96 lung cancer patients with selective VATS in Department of Cardio-Thoracic Surgery of Taizhou Hospital of Zhejiang Province were selected as control group from July 2014 to December 2014. A total of 91 lung cancer patients with selective VATS were chosen as experimental group between January 2016 to June 2016. Patients received postoperative acute pain management with the pain management mode of nurse-centered multidisciplinary cooperation in experimental group and traditional management model in control group. The differences were observed and compared among patients between two groups in the occurrence of moderate-severe pain,time of first ambulation,occurrence of postoperative complications,average hospital stay and so on. Results The score of NRS,incidence of moderate-severe pain in experimental group (3.25,6.59%) were lower than those (4.65,16.67%) in control group within 24 hours with significant differences (t/χ2=-2.247,4.567;P<0.05). There were statistically significant differences in the time of first ambulation and average hospital stay between experimental group [(19.11±7.49) h,(9.34±3.66) d] and control group [(27.40±11.91) h, (10.98±5.01) d] (t=-4.766,-2.024;P<0.05). There was no statistically significant difference in the occurrence of postoperative complications between two groups (P>0.05).Conclusions The importance of nurses in pain management of multidisciplinary cooperation becomes increasingly. The model can effectively promote quick recovery in postoperative patients and speed up the process of nursing professional development.

Tumor undergo uncontrolled, excessive proliferation leads to hypoxic microenvironment. To fulfill their demand for nutrient, and oxygen, tumor angiogenesis is required. Endothelial progenitor cells (EPCs) have been known to the main source of angiogenesis because of their potential to differentiation into endothelial cells. Therefore, understanding the mechanism of EPC-mediated angiogenesis in hypoxia is critical for development of cancer therapy. Recently, mitochondrial dynamics has emerged as a critical mechanism for cellular function and differentiation under hypoxic conditions. However, the role of mitochondrial dynamics in hypoxia-induced angiogenesis remains to be elucidated. In this study, we demonstrated that hypoxia-induced mitochondrial fission accelerates EPCs bioactivities. We first investigated the effect of hypoxia on EPC-mediated angiogenesis. Cell migration, invasion, and tube formation was significantly increased under hypoxic conditions; expression of EPC surface markers was unchanged. And mitochondrial fission was induced by hypoxia time-dependent manner. We found that hypoxia-induced mitochondrial fission was triggered by dynamin-related protein Drp1, specifically, phosphorylated DRP1 at Ser637, a suppression marker for mitochondrial fission, was impaired in hypoxia time-dependent manner. To confirm the role of DRP1 in EPC-mediated angiogenesis, we analyzed cell bioactivities using Mdivi-1, a selective DRP1 inhibitor, and DRP1 siRNA. DRP1 silencing or Mdivi-1 treatment dramatically reduced cell migration, invasion, and tube formation in EPCs, but the expression of EPC surface markers was unchanged. In conclusion, we uncovered a novel role of mitochondrial fission in hypoxia-induced angiogenesis. Therefore, we suggest that specific modulation of DRP1-mediated mitochondrial dynamics may be a potential therapeutic strategy in EPC-mediated tumor angiogenesis.
Anoxia ; Cell Movement ; Endothelial Cells ; Endothelial Progenitor Cells* ; Mitochondrial Dynamics* ; Oxygen ; RNA, Small Interfering