1.Neuronal ceroid lipofuscinosis in a Border Collie: a case report
Minsu SEO ; Yoonhoi KOO ; Dongjoon CHOI ; Sanggu KIM ; Taesik YUN ; Yeon CHAE ; Dohee LEE ; Hakhyun KIM ; Mhan-Pyo YANG ; Soochong KIM ; Byeong-Teck KANG
Korean Journal of Veterinary Research 2022;62(4):e27-
A 2-year-old spayed female Border Collie presented with visual deficits and behavioral changes. Neurological examination revealed bilateral menace response deficit with a normal pupil light reflex. Cerebral cortical thinning, cerebral sulci and cerebellar fissure widening, ventriculomegaly, and cerebral atrophy were observed on magnetic resonance imaging (MRI). Histopathology revealed fluorescent lipopigment accumulation in the cerebrum, and the dog was diagnosed with neuronal ceroid lipofuscinosis. This is the first case report describing the changes in clinical signs, MRI findings, and histopathologic changes in neuronal ceroid lipofuscinosis in Korea.
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