Despite of great advances in drug management of heart failure in the past ten years,the condition remains a major public health issue,with high prevalence,poor clinical outcomes.Treatment of established systolic chronic heart failure includes agents that block the renin-angiotensin-aldosterone and sympathetic nervous systems to prevent adverse remodelling,to reduce symptoms and prolong survival.Diuretics,Vasodilator and Digoxin are often used to improve sign,with no influence on prognosis.Pharmacological agents aimed at new targets on clinically relevant endpoints are going under investigating.

Objective To observe the effect of Melodic Intonation Therapy on severe aphasia.Methods Additionally to the stimulus therapy,familiar songs were used in the treatment of listening,retelling and naming in 12 cases.Results The patients showed improvement in listening,retelling and naming.Conclusion Using familiar songs in the treatment can promote the recovery of aphasic patients.

Objective To develop self-management behavior assessment scale for chemotherapy patients with peripherally inserted central catheter (PICC),and test the validity and reliability of it.Methods In reference to Chronic Disease Self Management Study Measure and its scoring standard by patient education and study center of American Stanford University,in combination with PICC patient self-management content,with reference to the literature,expert assessment,the self-management behavior assessment scale was established.The scale included five dimensions,19 quantitative indicators,a total of 78 entries.From February 2010 to November 2011 192 cases of breast cancer chemotherapy patients with PICC participated in the survey.Results Effective questionnaire was 178 copies,scale of content validity index (CVI) was 0.906,the overall Cronbach alpha coefficient was 0.892.Using factor analysis method,4 common factors were extracted whose characteristic root was greater than 1,and could explain 41.180％ of the total variance,each item on the corresponding factor of load was above 0.3.Conclusions The evaluation scale has good validity and reliability,which can provide researchers with a tool to evaluated and intervene with self management behavior of breast cancer chemotherapy patients with PICC.

Objective: To share the anti-infection experience for the patients with complicated intra-abdominal infection after operation.Methods: The whole course of drug administration participated by clinical pharmacist in one patient with complicated intra-abdominal infection after pancreatoduodenectomy were retrospectively analyzed and discussed.Results: Enterococcus was found in the blood culture and ascites.According to the results of drug sensitive tests, clinical pharmacist provided medication suggestions and performed medication mornitoring.According to the blood concentration, clinical pharmacist adjusted the dose of vancomycin, and changed the therapy regimen according to the changes of conditions.As a result, adverse reactions were controlled timely, and satisfactory treatment effects were obtained.Conclusion: The aetiology of complicated intra-abdominal infection is complex with intractable treatment, and the participation of clinical pharmacists in the treatment can improve the efficiency and safety.

Ovarian neoplasms,composed predominantly or exclusively of small round cells with scant cytoplasm,is relatively rare.However,there is a wide range of differentiation,and pathologists often struggle to make a correct diagnosis because of its overlapping histological features.Perhaps the best known neoplasm of this kind is ovarian small cell carcinoma of the hypercalcemic type,which may be confused with a wide range of neoplasm from sex cord-stromal tumor to neoplasm in the family of small round blue cell tumor to various undifferentiated malignancies.Small cell carcinoma of the pulmonary type may also arise from the ovary,and this may be a component of a typical ovarian surface epithelial-stromal tumor.Other small cell neoplasm that may arise within the ovary or involve the ovary includes intra-abdominal desmoplastic small round cell tumor,metastatic small cell carcinoma,peripheral primitive neuroectodermal tumor,and endometrial stromal sarcoma.In this review,the morphologic features of some of these neoplasms are described,as well the value of immunohistochemistry and other ancillary techniques in establishing a diagnosis.

目的：对完全性失语的患者经言语治疗后的结果进行分析。研究方法：对10 例完全性失语患者进行筛查，采用中国康复研究中心失语症检查及头颅CT、MRI确诊为完全性失语，并对患者进行语言治疗。结果：10 例患者中5 例有改善，并且在发病后7－12个月比发病后的前6 个月恢复得快。结论：完全性失语的患者经言语治疗后可在一定范围内得到恢复，但要达到日常生活交流必须借助辅助交流。本文同时就完全性失语的定义、言语特征及预后进行讨论。

Objective To investigate the characteristic and rehabilitation of polyglot aphasia.Methods A case whose native languages are both Chinese and Korean,and can also speak fluent Japanese,suffering aphasia after a traffic accident was reported.Results and Conclusion His communication ability mainly on understanding and expression improved after a few months rehabilitation.The rehabilitation in different languages improved on different level.