Purpose: We analyzed postoperative Frisby-Davis distance (FD2) stereotest scores and changes in the angle of deviation, and the correlation between postoperative FD2 stereotest scores and long-term surgical outcomes, in patients with intermittent exotropia. Methods: This retrospective study included patients aged less than 12 years with intermittent exotropia who underwent at least 28 months of postoperative follow-up. We analyzed the changes in the postoperative angle of deviation and preoperative and postoperative Titmus and FD2 stereotest scores. Surgical success rates at 28 months postoperatively were compared between the good (FD2 at 10 months postoperatively ≤ 10 arcsec) and bad (FD2 at 10 months postoperatively ≥ 15 arcsec) stereotest groups. Surgical success was defined as a horizontal deviation on distance measurement of 5 prism diopter (PD) esodeviation to 10 PD exodeviation at 1 year postoperatively. Results: This study included 101 patients. No significant difference was identified between preoperative and postoperative Titmus test scores. However, the FD2 stereotest scores were significantly improved at 10 months postoperatively (p = 0.001). A significant, positive correlation was observed between FD2 stereotest scores at 10 months postoperatively and the angles of deviation at distance at 10, 16, 22, and 28 months postoperatively (p ≤ 0.001 for all). The surgical success rates at 28 months postoperatively were 73.1% and 43.5% in the good and bad stereotest groups, respectively (p = 0.008). Conclusions Distance stereoacuity within 1 year postoperatively correlated with the postoperative angle of deviation at distance. Good distance stereoacuity (i.e., < 10 arcsec) within 1 year postoperatively correlated with a higher surgical success rate compared to bad distance stereoacuity.

Purpose: The results of the Hahn Chun Suk color test (Hahn test) and the Farnsworth-Munsell D-15 test (D-15 test) were compared in patients with acute optic neuritis. Methods: Patients with acute optic neuritis evaluated using both the Hahn and D-15 tests in the acute phase and 2 months later were evaluated. The results of the acute phase tests were compared. Correlations were sought between color deficiency and all of visual acuity, the visual field index (VFI), and the severity of optic disc edema. Changes in the test results 2 months later were also evaluated and correlated with other visual functions. Results: Twenty-seven eyes of 22 patients were enrolled. The mean patient age was 49.4 years and the logarithm of the minimum angle of resolution visual acuity 0.5. In the acute phase, the perception number was 10.06 in the Hahn test. On the D-15 test, the ‘strong’ grade predominated (40.7%). The concordance rates of severity and type were 55.6 and 54.5% between the two tests. In 9 of 12 eyes exhibiting inconsistent severity, the D-15 test afforded better results than did the Hahn test. A significant positive correlation was evident between the Hahn test results and visual acuity (r = 0.560, p = 0.002). The mean deviation (MD) and the VFI also correlated with the results of the Hahn test (r = -0.432, p = 0.027 for the MD; r = -0.517, p = 0.007 for the VFI). The D-15 test results correlated only with visual acuity (r = 0.476, p = 0.012). After 2 months, the results of both tests correlated significantly only with visual acuity. Conclusions In the acute phase, the concordances of the Hahn and D-15 test results were 55.6% in terms of severity and 54.5% in terms of type. The Hahn test results correlated with the visual acuity and VFI. In contrast, the D-15 test results correlated with visual acuity only.

Purpose: We report a case of ocular toxoplasmosis that caused bilateral optic atrophy secondary to papillitis.Case summary: A 52-year-old male with no history of systemic disease was referred to our clinic because of visual field blurring in the left eye for four weeks. The visual acuity was 20/20 in the right eye and 20/25 in the left eye. A relative afferent pupillary defect and diffuse field loss were noted in the left eye. On fundus examination, left-side blurring of the disc margin and a peripapillary hemorrhage were evident, but there was no sign of inflammation in the right fundus. Systemic evaluation, including brain magnetic resonance imaging, was performed for differential diagnosis of left papillitis. Immunoserologically, he was positive for toxoplasma immunoglobulin (Ig)M and IgG. We diagnosed ocular toxoplasmosis presenting as left papillitis, and systemic antibiotics and a steroid were started. After six weeks, the left disc swelling was reduced but disc pallor was evident and his visual acuity decreased to 20/40. A new inflammatory lesion of the right optic disc developed two weeks after the medication was stopped, so the treatment was applied for a further two months. However, bilateral optic atrophy developed. Conclusions Bilateral papillitis caused by ocular toxoplasmosis may trigger optic atrophy secondary to optic nerve involvement.When a patient presents with disc swelling suggestive of papillitis caused by ocular toxoplasmosis, rapid and aggressive antitoxoplasma treatment is essential to avoid a poor visual outcome.

Purpose: We report a case of idiopathic chiasmal optic neuritis in a pediatric patient.Case summary: A 13-year-old boy with no history of systemic disease was referred to our ophthalmology clinic because of visual disturbance in both eyes of 5 days in duration. The best-corrected visual acuity was 0.08 in the right eye and finger counting at 30 cm in the left eye; mild blurring of the disc margins (both eyes) was evident on fundus examination, as were temporal hemianopsia in the right eye and diffuse field loss in the left eye. Brain magnetic resonance imaging revealed focal nodular enhancement in the optic chiasm. Blood and cerebral fluid analysis yielded no evidence of infection or autoimmune disease. Therefore, we diagnosed isolated idiopathic chiasmal optic neuritis and commenced a systemic steroid. After 5 days, the visual acuity began to improve, and the field defect was almost eliminated (except for a small central scotoma) at 1 month. He has remained stable to the time of writing (4 months after treatment) and his visual acuity has normalized. Conclusions Isolated idiopathic chiasmal optic neuritis developed in a pediatric patient and the visual function improved after steroid treatment. Although there was no evidence of systemic demyelinating disease, regular observation is scheduled given the possibility of late-onset disease.

Purpose: We analyzed the characteristics of patients with refractive accommodative esotropia (RAET) who required glasses for stable alignment after a myopic shift. Methods: We retrospectively analyzed the medical records of patients diagnosed with RAET at the initial visit, and who had developed a myopic shift in both eyes over the 5-year follow-up period. To evaluate clinical factors associated with the persistence of esotropia after myopia, the enrolled patients were divided into two groups; patients with RAET who needed glasses for stable alignment after a myopic shift (unstable group) and patients with RAET whose esotropia resolved after a myopic shift (stable group). Results: A total of 55 patients met the inclusion criteria. The mean follow-up period was 13.8 ± 5.7 years (5-27 years). Spherical equivalent (SE) refractive errors at the initial visit were +3.1 ± 1.6 diopters (D) (+1.00 to +7.25 D) and -1.5 ± 0.9 D (-4.38 to -0.5 D) at the last visit. Of the 55 RAET patients, 24 were included in the unstable group and 31 were included in the stable group. No significant differences in gender, age at diagnosis, SE refractive error, or angle of esotropia with glasses were observed between the two groups. However, significantly more patients failed the Lang I test or had anisometropia over 1.5 D at the last visit, and the duration between the onset of esotropia and prescribing glasses was significantly longer in the unstable group than in the stable group. Conclusions Glasses may be needed for stable alignment even after a myopic shift in RAET patients with long durations of misalignment, poor stereopsis, and anisometropia.

Purpose: We analyzed the characteristics of patients with refractive accommodative esotropia (RAET) who required glasses for stable alignment after a myopic shift. Methods: We retrospectively analyzed the medical records of patients diagnosed with RAET at the initial visit, and who had developed a myopic shift in both eyes over the 5-year follow-up period. To evaluate clinical factors associated with the persistence of esotropia after myopia, the enrolled patients were divided into two groups; patients with RAET who needed glasses for stable alignment after a myopic shift (unstable group) and patients with RAET whose esotropia resolved after a myopic shift (stable group). Results: A total of 55 patients met the inclusion criteria. The mean follow-up period was 13.8 ± 5.7 years (5-27 years). Spherical equivalent (SE) refractive errors at the initial visit were +3.1 ± 1.6 diopters (D) (+1.00 to +7.25 D) and -1.5 ± 0.9 D (-4.38 to -0.5 D) at the last visit. Of the 55 RAET patients, 24 were included in the unstable group and 31 were included in the stable group. No significant differences in gender, age at diagnosis, SE refractive error, or angle of esotropia with glasses were observed between the two groups. However, significantly more patients failed the Lang I test or had anisometropia over 1.5 D at the last visit, and the duration between the onset of esotropia and prescribing glasses was significantly longer in the unstable group than in the stable group. Conclusions Glasses may be needed for stable alignment even after a myopic shift in RAET patients with long durations of misalignment, poor stereopsis, and anisometropia.

Purpose: To explore the subjective eye health status of Korean adolescents by the extent of Internet use in 2009-2010 and smartphone use in 2020. Methods: We secondarily analyzed the results of the Korea Youth Risk Behavior Survey performed by the Korean Disease Control and Prevention Agency that enrolled Korean adolescents aged 12-18 years. Changes in internet use time from 2009 to 2019 and smartphone use in 2020 were examined. Questionnaires exploring subjective eye health were administered in 2009, 2010, and 2020. We performed complex logistic regression analysis. Results: A total of 748,490 subjects were enrolled. Korean adolescents used the Internet for an average of 2.48 hours (h) on weekdays and 4.06 h on weekends in 2019, thus significantly more than the 2009 averages of 1.93 h on weekdays and 2.96 h on weekends (both p < 0.001). In 2009 and 2010, the average internet use time on weekends significantly and positively correlated with subjective eye problems (odds ratio = 1.161, p < 0.001). The average smartphone use time was 4.72 h on weekdays and 6.56 h on weekends in 2020. In that year, the average smartphone use time on weekends (odds ratio = 1.049, p < 0.001) and smartphone overdependence (odds ratio = 8.636, p < 0.001) significantly and positively correlated with the presence of subjective health problems. Conclusions Internet and smartphone use time on weekends affect subjective eye health.

PURPOSE: To evaluate the effect of intravitreal aflibercept according to subfoveal choroidal thickness in patients with polypoidal choroidal vasculopathy (PCV). METHODS: We retrospectively analyzed the medical records of 60 eyes from 60 patients with PCV treated with intravitreal aflibercept. The patients were followed for at least 6 months after the first injection. Using software, subfoveal choroidal thickness was manually measured as the distance from the hyper-reflective line of Bruch's membrane to the chorioscleral interface on optical coherence tomography. The patients were divided into three groups based on subfoveal choroidal thickness. Visual acuity, subfoveal choroidal thickness, central macular thickness and largest pigment epithelial detachment (PED) height, polyp regression rate, and dry macula rate were evaluated to analyze the anatomical and functional outcomes. RESULTS: Baseline mean subfoveal choroidal thickness were 178.50 ± 28.42 µm in the thin group (14 eyes, 23.3%), 287.03 ± 43.58 µm in the medium group (33 eyes, 55.0%), and 379.77 ± 17.09 µm in the thick group (13 eyes, 21.7%). Baseline age, sex, visual acuity, central macular thickness, and the largest PED height did not differ significantly among the three subgroups. Only the thin group showed significant improvement of visual acuity at 6 months (p = 0.005). Subfoveal choroidal thickness, central macular thickness, and largest PED height were significantly decreased after treatment in all subgroups and did not differ among the subgroups. Compared with the other groups, the thin subfoveal choroidal thickness group showed higher polyp regression rate at 3 months and higher dry macula rate at 6 months (p = 0.013 and p = 0.004, respectively). CONCLUSIONS: Intravitreal aflibercept injection was effective for the treatment of PCV, and thin subfoveal choroidal thickness was associated with better anatomical and functional outcomes.
Bruch Membrane ; Choroid* ; Humans ; Medical Records ; Polyps ; Retrospective Studies ; Tomography, Optical Coherence ; Visual Acuity

Purpose: To investigate the changes in peripapillary and macular vessel density in ethambutol-induced optic neuropathy using optical coherence tomography angiography (OCTA). Methods: The medical records of patients diagnosed with ethambutol-induced optic neuropathy were analyzed retrospectively. Patient age, sex, daily dose (mg/day/kg), treatment duration, best-corrected visual acuity (logMAR), color vision (Ishihara color plate tests), and mean deviation of visual field test were evaluated in non-pathological individuals with age and sex controlled as the normal control group. Peripapillary retinal nerve fiber layer (RNFL) thickness, macular ganglion cell/inner plexiform layer (GC/IPL) thickness, radial peripapillary capillary (RPC) density, and macular superficial capillary plexus (SCP) density were also compared between the patient and control groups. Results: The study included 22 patient eyes and 31 control group eyes. Comparing the OCTA results between the groups, there were no significant differences in peripapillary RNFL thickness, but the temporal RPC density was significantly (p = 0.025) lower in the patient group (48.00 ± 8.23%) than in controls (52.39 ± 5.58%). For macular structures, the mean GC/IPL thickness and whole SCP density were lower in the patients (p = 0.001 and p = 0.008, respectively). In the patients, the changes in peripapillary RNFL thickness and RPC density were significantly positively correlated (r = 0.811, p < 0.001), as were the mean macular GC/IPL thickness and whole SCP density (r = 0.445, p = 0.037). Conclusions Patients with ethambutol-induced optic neuropathy had significantly lower temporal RPC and macular SCP densities. Ethambutol toxicity may affect not only axonal degeneration but also peripapillary and macular vascular function.

Purpose: To compare optical coherence tomography angiography (OCTA) findings between severe non-proliferative diabetic retinopathy (NPDR) and unexposed proliferative diabetic retinopathy (PDR), and identify predictive factors. Methods: Patients newly diagnosed with severe NPDR or unexposed PDR between January 2018 and December 2021 were reviewed retrospectively. Unexposed PDR was diagnosed using fluorescein fundus angiography, because new vessels could not be observed in the poster pole or clearly distinguished in the retinal periphery on wide fundus photography. Clinical features at the time of diagnosis, and OCTA measurements (mean vascular density, superficial capillary plexus (SCP) foveal avascular zone (FAZ) area, and mean retinal thickness), were compared between the two groups. Factors that could predict unexposed PDR were investigated using multivariate analysis with a generalized estimating equation. Results: A total of 61 severe NPDR and 23 unexposed PDR eyes were included. The unexposed PDR had significantly larger SCP-FAZ areas (p = 0.031) and lower total and parafoveal mean inner retinal thicknesses (p = 0.014 and p < 0.001, respectively). However, there were no differences in mean vascular density between the groups (p > 0.05). Multivariate analysis showed that SCP-FAZ area and parafoveal mean inner retinal thickness were significant predictors of unexposed PDR (p = 0.027 and p = 0.001, respectively). Conclusions In severe NPDR patients, unexposed PDR may be considered a differential diagnosis when the SCP-FAZ area is large or the parafoveal mean inner retinal thickness is small.