Objective:To explore the application effect of quality control rehabilitation nursing in patients with dysphagia after acute stroke.Methods:A total of 122 patients with dysphagia after acute stroke who were admitted to Bozhou People's Hospital from April 2018 to March 2021 were selected as the research objects by the convenient sampling method. According to the random number table method, they were divided into the observation group and the control group, with 61 cases in each group. The control group was given routine rehabilitation nursing, while the observation group was given quality control rehabilitation nursing on this basis. Standardized Swallowing Assessment (SSA) and Swallow Quality-of-Life Questionnaire (SWAL-QOL) were used to evaluate the intervention effect.Results:Among the 122 patients, 3 patients died, 2 patients voluntarily gave up treatment and 2 patients were excluded from the study due to other reasons. A total of 115 patients were included, including 58 in the observation group and 57 in the control group. After intervention, the SSA score of the observation group was lower than that of the control group and the SWAL-QOL score was higher than that of the control group, and the differences were statistically significant ( P<0.05) . Conclusions:Quality control rehabilitation nursing can improve the swallowing function and quality of life of patients with dysphagia after acute stroke.

OBJECTIVE: To study the correlation of genome-wide distribution of 6-methyladenine (6mA) of DNA in chorionic tissues from abortuses with monosomy 21. METHODS: Genomic DNA was extracted from chorionic samples from four abortuses with monosomy 21 and four without. After quality and purity test, partial DNA was subjected to chromatin immunoprecipitation with anti-6mA antibody, and then identified by sequencing. The sequencing data was analyzed by using bioinformatic software for the difference in 6mA between the two groups. RESULTS: Analysis of read peaks suggested that the control group have much more 6mA genes (n=4607) compared with the experiment group (n=1059). For chromosome 21, this difference is even more pronounced (8032 vs. 1769). Above results suggested that the level of 6mA modification in monosomy 21 is low. Gene ontology enrichment analysis and KEGG pathway enrichment analysis indicated that the absence of 6mA genes in monosomy 21 is closely related to the growth and development of embryo. CONCLUSION The 6mA modification of human genes may play a similar role to 5-methylcytosine (5mC) modification during the growth and development of embryos.