1.Unusual Giant Arteriovenous Malformation in Jejunum: A Case Report.
Journal of the Korean Association of Pediatric Surgeons 2017;23(2):52-54
Polypoid or tumorous arteriovenous malformation (AVM) of small intestine is rare and can be misdiagnosed as other tumorous conditions. We experienced a rare case of giant jejunal AVM in a 15-year-old boy, who complained of intense abdominal pain. Ultrasonography and contrast-enhanced CT revealed a 13.5-cm-sized multiseptated cystic mass arising in small intestine, which was mimicking submucosal tumor. It was successfully treated by surgical resection. The specimen showed a multilobulated outbulging submucosal mass in jejunum. Histopathologic evalulation confirmed AVM located in the submucosa, muscularis propria and subserosa. This case is the largest AVM of small intestine among which has ever been reported.
Abdominal Pain
;
Adolescent
;
Arteriovenous Malformations*
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Humans
;
Intestine, Small
;
Jejunum*
;
Male
;
Tomography, X-Ray Computed
;
Ultrasonography
2.Fine Needle Aspiration Cytology of Eccrine Spiradenoma: Report of a Case.
Korean Journal of Cytopathology 2005;16(2):98-101
Eccrine spiradenoma is a rare adnexal tumor of the skin and its cytomorphology has seldom been described in literature. To evaluate the cytologic features and diagnostic pitfalls of eccrine spiradenoma, we report a case of 33-year-old male whose clinical presentation was a painful subcutaneous mass at the right preauricular area. Fine needle aspirates revealed tight clusters of multilayered, uniform, cuboidal cells arranged around hyalinized perivascular spaces. Some epithelial cells showed tubules or rosette formations. The background showed scattered, naked nuclei. The histologic findings confirmed the eccrine spiradenoma. The recognition of peculiar cytologic features and clinical correlation could be helpful in the diagnosis of skin adnexal tumors.
Adult
;
Biopsy, Fine-Needle*
;
Diagnosis
;
Epithelial Cells
;
Humans
;
Hyalin
;
Male
;
Needles
;
Rosette Formation
;
Skin
3.Sudden Child Death due to Thrombotic Giant Coronary Artery Aneurysms Complicated by Atypical Kawasaki Disease: An Autopsy Case
DongJa KIM ; Man Hoon HAN ; SangHan LEE
Journal of Pathology and Translational Medicine 2018;52(4):248-251
No abstract available.
Aneurysm
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Autopsy
;
Child
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Coronary Vessels
;
Humans
;
Mucocutaneous Lymph Node Syndrome
4.The Role of Microsatellite Instability at Chromosome 11p15.5 in the Progression of Breast Ductal Carcinoma.
Dong Ja KIM ; Ji Young PARK ; Myung Hoon LEE ; Yoon Kyung SOHN
Journal of Korean Medical Science 2004;19(5):698-703
The study of microsatellite instability (MSI) has provided the evidence to support asequential, progressive pathway for the development of cancer. In this study, we analyzed the role of MSI at chromosome 11p15.5 using microdissection of paraffin-embedded tissue from 68 matched normal and breast tumor samples. Components of intraductal, invasive and metastatic foci in lymph node were assessed for MSI using the polymorphic markers D11S922, tyrosine hydroxylase (TH) and D11S988. We found that MSI at D11S922 was relatively high incidence than other two markers and increased during breast cancer progression. The overall frequency of MSI at D11S922 was 26.7% in pure intraductal carcinoma, 36.4% in invasive carcinoma, and 40.0% in invasive carcinoma with metastases. We observed no significant correlation between MSI at chromosome 11p15.5 and the patient's age, tumor size, histological grade, or lymph node metastasis. We compared the MSI incidence with the expression of prognostic markers, such as p53, c-erb B2, estrogen receptor, and progesterone receptor, and found no significant correlation. We suggest that the MSI of chromosome 11p15.5 is increased during breast cancer progression, but long-term follow-up study would establish whether MSI at chromosome 11p15.5 could be useful as a potential prognostic marker for breast cancer.
Breast Neoplasms/*genetics/metabolism/pathology
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Carcinoma, Ductal, Breast/*genetics/metabolism/pathology
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Carcinoma, Intraductal, Noninfiltrating/*genetics/metabolism/pathology
;
*Chromosomes, Human, Pair 11
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Female
;
Humans
;
Immunohistochemistry
;
Microsatellite Repeats
;
Prognosis
;
Protein p53/metabolism
;
Receptor, erbB-2/metabolism
;
Receptors, Estrogen/metabolism
;
Receptors, Progesterone/metabolism
5.Expression and Mutational Analysis of c-kit in Ovarian Surface Epithelial Tumors.
Dong Ja KIM ; Myung Hoon LEE ; Tae In PARK ; Han Ik BAE
Journal of Korean Medical Science 2006;21(1):81-85
Coexpression of Kit ligand and c-kit has been reported in some gynecologic tumors. To determine whether imatinib mesylate is useful in ovarian epithelial tumors, we performed immunohistochemical and mutational analysis. The cases consisted of 33 cases, which included 13 serous cystadenocarcinomas, 1 borderline serous tumor, 8 mucinous cystadenocarcinomas, 6 borderline mucinous tumors and 5 clear cell carcinomas. Five cases of serous cystadenoma and 5 cases of mucinous cystadenoma were also included. In the immunohistochemical study, 3 cases (3/6, 50%) of borderline mucinous cystic tumor and two cases (2/8, 25%) of mucinous cystadenocarcinoma show positive staining for KIT protein. Only one case (1/13, 7.7%) of serous cystadenocarcinoma had positive staining. On mutational analysis, no mutation was identified at exon 11. However, two cases of borderline mucinous tumors and one case of mucinous cystadenocarcinoma had mutations at exon 17. In these cases, the immunohistochemistry also shows focal positive staining at epithelial component. Although, KIT protein expression showed higher incidence in mucinous tumors than serous tumors, they lack KIT-activating mutations in exon 11. Thus, ovarian surface epithelial tumors are unlikely to respond to imatinib mesylate.
Adult
;
Aged
;
Cystadenocarcinoma, Mucinous/genetics/metabolism/pathology
;
Cystadenoma, Mucinous/genetics/metabolism/pathology
;
Cystadenoma, Serous/genetics/metabolism/pathology
;
DNA Mutational Analysis
;
DNA, Neoplasm/chemistry/genetics
;
Epithelial Cells/chemistry/metabolism/pathology
;
Female
;
Gene Expression Regulation, Neoplastic
;
Humans
;
Immunohistochemistry
;
Middle Aged
;
Mutation
;
Ovarian Neoplasms/genetics/metabolism/*pathology
;
Polymerase Chain Reaction
;
Polymorphism, Single-Stranded Conformational
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Proto-Oncogene Proteins c-kit/biosynthesis/*genetics
6.Fine Needle Aspiration Cytologic Diagnosis of Thymoma Presenting as a Thyroid Nodule: A Report of Two Cases.
Dong Ja KIM ; Ji Young PARK ; Yoon Seup KUM ; Tae In PARK ; Yoon Kyung SOHN
Korean Journal of Cytopathology 2000;11(1):41-46
Thymoma is the most common anterior mediastinal tumor in adults. Rarely, it is presented as the anterior neck mass, commonly located in the anterolateral aspect of the neck or adjacent to the thyroid. We experienced two cases of fine needle aspiration cytology of thymoma, mimicking thyroid mass. The first case was an ectopoic cervical thymoma in a 31-year-old female. The fine needle aspiration cytology was misinterpreted as reactive hyperplasia of lymph node. But the histologic diagnosis was thymoma, predominantly lymphocytic type. The second case was an invasive thymoma in a 66-year-old female, who complained a large anterior neck mass. The fine needle aspiration cytology revealed biphasic population of some clusters of epithelial cells and scattered lymphocytes. The cytologic diagnosis was thymoma and was confirmed as invasive thymoma after the biopsy. Therefore, when the cytologic feature of anterior neck mass shows the both lymphocyte and epithelial component, the differential diagnosis should include the possibility of thymoma.
Adult
;
Aged
;
Biopsy
;
Biopsy, Fine-Needle*
;
Diagnosis*
;
Diagnosis, Differential
;
Epithelial Cells
;
Female
;
Humans
;
Hyperplasia
;
Lymph Nodes
;
Lymphocytes
;
Neck
;
Thymoma*
;
Thyroid Gland*
;
Thyroid Nodule*