1.Bone SPECT and CT fusion imaging in pediatric neuroblastoma
Wei, DONG ; Mei, LI ; Hao-jie, DAI ; Hui-dong, CHEN
Chinese Journal of Nuclear Medicine 2011;31(6):386-389
ObjectiveTo evaluate the diagnostic performance of bone SPECT and CT fusion imaging in bone metastases from pediatric neuroblastoma.MethodsTwenty-four pediatric patients with neuroblastoma were included in this retrospective study.All patients underwent planar imaging and SPECT integrated with CT.Lesion visibility,diagnostic certainty and diagnostic performance were evaluated with KolmogorovSmirnov test andx2 test.ResultsLesion visibility of SPECT alone,SPECT integrated with CT were significantly better than that of planar imaging ( both H =69.000,P < 0.05 ).SPECT and CT fusion imaging,SPECT alone both detected five more bone lesions than planar bone imaging (77 vs 72).The diagnostic accuracy of SPECT imaging (62.34%,48/77 )was significantly higher than that of planar imaging (45.45%,35/77; x2 =4.416,P < 0.05 ).The sensitivity,specificity and accuracy of SPECT and CT fusion imaging for diagnosing malignant bone lesions were significantly higher than those of planar imaging:82.35% (42/51) vs 53.19% ( 25/47),88.46% ( 23/26 ) vs 40.00% ( 10/25 ),84.42% ( 65/77 ) vs 45.45% (35/77 ; x2 =12.571,14.016,25.667,all P < 0.01 ).The diagnostic specificity and accuracy of SPECT and CT fusion imaging were significantly higher than those of SPECT alone ( 53.85%,14/26 ;62.34%,48/77) (x2 =7.589,9.606,both P <0.01 ).However,there was no significant difference of sensitivity between the two methods (x2 =2.942,P > 0.05 ).Diagnostic certainty by SPECT and CT fusion imaging was significantly higher than that by SPECT alone ( H =28.000,P < 0.05 ) and by planar imaging (H =21.000,P < 0.05).ConclusionSPECT and CT fusion imaging can detect more bone lesions in patients with pediatric neuroblastoma.It is helpful for diagnosing bone metastases from pediatric neuroblastoma.
3.A case report of Kearns-Sayre syndrome.
Wei-hua ZHANG ; Qian TONG ; Dong-mei CHEN
Chinese Journal of Cardiology 2011;39(4):369-369
4.Exploration of prognostic factors in extranodal nasal-type NK/T cell lymphoma.
Dong-mei HAN ; Xie-qun CHEN ; Qing-xian BAI
Chinese Journal of Oncology 2006;28(2):137-137
Adult
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Aged
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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Female
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Ferritins
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blood
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Hemoglobins
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metabolism
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Humans
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Killer Cells, Natural
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L-Lactate Dehydrogenase
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blood
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Lymphoma, T-Cell
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blood
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drug therapy
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pathology
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Male
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Middle Aged
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Neoplasm Staging
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Nose Neoplasms
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blood
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drug therapy
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pathology
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Prognosis
7.Treatment of orbital wall fracture in the anophthalmic patient.
Zhi-yuan CHEN ; Jing-ming LIU ; Dong-mei LI
Chinese Journal of Stomatology 2008;43(11):693-694
Adult
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Eye Injuries
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surgery
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Female
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Humans
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Orbital Fractures
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surgery
8.ISOLATION AND IDENTIFICATION OF STEROIDAL SAPONINS FROM DIOSCOREA PANTHAICA PRAIN ET BURKILL
Mei DONG ; Lijun WU ; Quan CHEN ; Benxiang WANG
Acta Pharmaceutica Sinica 2001;36(1):42-45
AIM To investigate the chemical constituents of the rhizomes of Dioscorea panthaica Prain et Burkill and look for new active compounds. METHODS The compounds were isolated with silica gel and HPLC, and their structures were elucidated on the basis of chemical evidences and spectral analysis (IR, ESI-MS, 1HNMR, 13CNMR, DEPT, 1H-1H COSY, HMQC, HMBC, NOESY). RESULTS Three steroidal saponins were isolated from the rhizomes of Dioscorea panthaica. They were elucidated as 26-O-β-D-glucopyranosyl-3β,26-diol-23(S)-methoxy-25(R)-Δ5,20(22)-diene-furosta-3-O-[α-L-rhamnopyranosyl-(1→2)-O-α-L-rhamnopyranosyl-(1→4)]-β-D-glucopyranoside (I), pseudoprotodioscin (II), 26-O-β-D-glucopyranosyl-3β,26-diol-25(R)-Δ5,20(22)-diene-furosta-3-O-α-L-rhamnopyranosyl-(1→2)-O-β-D-glucopyranoside (III). CONCLUSION Compound I is a new steroidal saponin and was named as dioscoreside C. Compound II and III were obtained from this genus for the first time.
9.The Neuropsychological Analysis of Agraphia After Basal Ganglia Infarction
Mei JIN ; Xiaojia LIU ; Dong CHEN ; Wengang YIN
International Journal of Cerebrovascular Diseases 2008;16(3):169-172
Objective:To investigate the neuropsychological characteristics of Chinese agraphia caused by basal ganglia(BG)infarction.Methods:The writing abilities of 40 patients with BG infarction were detected by Chinese agraphia battery(CAB),and all the writing scores and agraphia quotient were calculated.The head CT/MRI images in agraphia and non-agraphia groups were standardized,the infarction were revealed and the superposition of two-dimensional arrays were performed,so that the central tendency of infarction was visually displayed.Results: Among the 40 patients,21 had left BG infraction,and 17 had agraphia;19 had right BG infraction,and 4 had agraphia.The two-dimensional superimposing neuroimages showed that BG infarctions caused agraphia was mostly in the left BG,including the left putamen,the head and body of the caudate nucleus,but there were fewer infarctions in the right putamen and the body of the candate nucleus.BG infarction caused agraphia was mostly aphasic agraphia,which was characterized by the orthographic disorders,paragraphia,and grammar mistakes.Conclusions: BG infarction may result in aphasic agraphia,which suggested that BG is involed in writing and processing,and it is the subcortical center of this advanced neurofunction in writing.
10.Osteoporosis-related knowledge, attitudes,and behaviors of residents from a community in Shnnohai
Zhonghua LIU ; Yiqun ZHANG ; Jianhua SHENG ; Xusheng CHEN ; Mei DONG
Chinese Journal of Health Management 2008;2(4):203-206
Objective To understand and raise the level of osteopomsis-relied knowledge, attitudes and behaviors for prevention and treatment of osteoperosis(OP)in residents of a community. Methods A survey was performed with a questionnaires method targeting at the elderly residents in Changfeng community.The survey was conducted with a specifically designed questionnaire,followed by a second survey.during which health edueafion was stressed.Data were analyzed with SPSS 11.0 software. Results In 3524 residents.3367 responded positively.The ratio of male to female was 1:2.10.The average age of the respondents was 61.34 years.They demonstrated a low level of OP KAP.76.72% of them heard the term of OP,60.11% had a correct judgment of their own bone heahh,42.26% knew the cause of OP.and 37.75% understood the diagnostic method of OP.The level of OP KAP varied in different groups of targeted residents.Of all the questions.the understanding of the diagnosis ranked the lowest.2281 people participated in the second survey,which showed improvement in their OP KAP.The difference was statistically significant.1439 people auended the consultation.99.86% of them considered the activities necessary,96.92% expressed their satisfaction,and 98.54% planed tO take measures to improve their bone health.Conclusion The poor understanding of bone heaith status and the knowledge about prevention and treatment of OP is why it is widely spread in the modem society,which however Call be improved by education.