1.Protective effects of astragalosides on pancreatic tissue in diabeticrats
International Journal of Traditional Chinese Medicine 2016;38(3):242-246
Objective To investigate the protective effects of astragalosides on pancreatic tissue in diabetic rats.Methods The experimental diabetic rat models were made by feeding with high fat and sugar and injecting STZ, and according to blood glucose level, the rat models were randomly devided into five groups: a diabetic model control group, an astragalosides low (30 mg/kg), a medium (60 mg/kg), a high (120 mg/kg) dose treated groups and a metformin hydrochloride 200 mg/kg treated group (n=16), and selected another 16 same-aged rats as a normal control group. 72 h after the models were made, the drugs were given by intragastric administration for 4 weeks, once a day. Before and after the drugs were given 7, 14, 21, 28 days, the level of plasma glucose (FPG) and insulin (FINS) were determined, and the ISI and HOMA-IR were calculated, the level of T-AOC and the content of ROS in serum were detected, the activity of SOD, CAT and the content of MDA in pancreatic tissue were detected, the histopathological changes of pancreatic tissue and pancreatic cells apoptosis were observed, and the apoptosis index were analyzed.Results Four weeks later, compared with the diabetic model control group, the FINS (9.34 ± 1.67 mIU/ml, 10.46 ± 1.51 mIU/mlvs.7.37 ± 1.39 mIU/ml) and the level of ISI (6.82 ± 0.96, 6.52 ± 0.79vs.7.35 ± 0.84) in astragalosides medium and high dose treated groups were significantly increased (P<0.05 orP<0.01), the level of HOMA-IR (43.62 ± 5.26, 29.37 ± 4.51vs.61.70 ± 5.85) were significantly decreased (P<0.05 orP<0.01). The level of FPG (9.32 ± 2.57 mmol/Lvs.17.15 ± 2.54 mmol/L) in astragalosides high dose treated group was significantly decreased (P<0.01), the level of T-AOC (12.20 ± 3.36 U/L vs.9.34 ± 2.59 U/L) in serum was significantly increased (P<0.01). The activity of SOD (11.52 ± 2.31 U/mg, 15.29 ± 2.50 U/mgvs.7.53 ± 1.86 U/mg) in serum of astragalosides medium and high dose treated groups were significantly increased (P<0.05 orP<0.01). The content of MDA (2.83 ± 0.37 nmol/mg, 1.92 ± 0.31 nmol/mgvs. 4.08 ± 0.42 nmol/mg) in pancreatic tissue of astragalosides medium, high dose treated groups were significantly decreased (P<0.05 orP<0.01); the activity of SOD (11.52 ± 2.31 U/mg, 15.29 ± 2.50 U/mgvs.7.53 ± 1.86 U/mg) and CAT (392.28 ± 38.05 U/g, 461.73 ± 42.52 U/gvs. 280.46 ± 29.61 U/g) were significantly increased (P<0.05 orP<0.01).Conclusion Astragalosides had protective effects on pancreatic tissue in diabetic rats.
2.Oral health and the war crisis.
Journal of Korean Academy of Oral Health 2017;41(3):163-164
No abstract available.
Oral Health*
3.A case of delivery in paroxysmal noctumal hemoglobinuria.
Korean Journal of Obstetrics and Gynecology 1991;34(6):865-870
No abstract available.
Hemoglobinuria*
4.The Critical Text from Boramae's Medical Dispute.
Journal of the Korean Medical Association 2004;47(9):814-817
No abstract available.
Dissent and Disputes*
5.The Critical Text from Boramae's Medical Dispute.
Journal of the Korean Medical Association 2004;47(9):814-817
No abstract available.
Dissent and Disputes*
6.Secondary Pneumothorax in the newborn.
Journal of the Korean Pediatric Society 1985;28(2):123-130
No abstract available.
Humans
;
Infant, Newborn*
;
Pneumothorax*
7.Peumomediastinum in the Newborn.
Journal of the Korean Pediatric Society 1985;28(3):217-224
No abstract available.
Humans
;
Infant, Newborn*
8.Some Future-oriented Roles and Phases for the Ethics Committee of KMA.
Journal of the Korean Medical Association 2001;44(9):938-940
No abstract available.
Ethics Committees*
;
Ethics*
9.Risk factors analysis of feeding intolerance in preterm infants
Clinical Medicine of China 2014;30(11):1217-1219
Objective To investigate the risk factors of feeding intolerance in preterm infants and provide reference for the prevention and intervention.Methods Two hundred and Seventy preterm infants were included in the study.The clinical data were collected to analyze the risk factors.Results There were 108 cases showed feeding intolerance.Gestational age,weight,1 minute Apgar,fetal distress,application of aminophylline,stomach bleeding,application of ventilator,prenatal use of GCs,abnormal placenta,perinatal infection were related factors of feeding intolerance in preterm infants.Multivariate Logistic regression analysis showed that application of aminophylline,stomach bleeding,application of ventilator were the independent risk factors of premature infants with feeding intolerance,gestational age was protective factors of feeding intolerance.Conclusion Premature infants with feeding intolerance caused by a variety of factors,and the reasonable measures of prevention and intervention were needed.
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