1.The Effect of Acanthopanax Koreanum Extract on the Induction of Collagen Induced Arthritis for DBA / 1J Mice.
The Journal of the Korean Rheumatism Association 1998;5(1):45-55
OBJECTIVE: No medication currently available for the treatment of rheumatoid arthritis is universally effective, and all can produce adverse effects. It is well known that the Acanthopanax koreanum extract has an anti-inflammatory action without any adverse effects reported. We conducted this study whether the Acanthopanax koreanum extract has a preventive and/or regressive effect of collagen induced arthritis in DBA/1J mice. METHODS: Three groups of BDA/1J mice were immunized by intradermal injection of 5ma/ka bovine type lI collagen with complete Freund s adjuvant. Group received 20ma/ka of Acanthopanax koreanum extract orally twice weekly and group K received 1ma/ka dexamethasone intraperitoneally twice weekly. Group ll and lll were divided into two subgroups respectively(Group Il-A, E-B, lll-A and Ill-B). Subgroup A is prevention group(Drugs were started to be given 3 weeks after immunization) and subgroup B is suppression group(Drugs were started to be given 6 weeks after immunization when CIA had been developed already). Group I received no treatment. The prevalence of arthritis were assessed twice weekly. Serum anti-collagen antibody and splenic mononuclear cell stimulation indices (SI) to collagen were measured. Serum tumor necrosis factor-a and interleukin-10 levels were also measured by ELISA. RESULT: Collagen induced arthritis(CIA) started to develop 4 weeks after collagen injections. In Acanthopanax koreanum extract treated group, CIA induction seemed not to be inhibited, but questionably partial supressive effect of arthritis were observed at 10 weeks after collagen injection. In dexamethasone treated group, both of prevention and suppression of CIA could be observed. Levels of anti-collagen antibodies were reduced in dexamethasone treated group, but not in the Acanthopanax koreanum extract treated group. No significant differences of splenic mononuclear cell SI among the groups was observed. There were no significant differences in the levels of serum tumor necrosis factor-a and interleukin-10 among the groups. CONCLUSIONS: These findings showed that the Acanthopanax koreanum extract does not have a definite effect on induction or supression of CIA.
Eleutherococcus*
;
Animals
;
Antibodies
;
Arthritis*
;
Arthritis, Rheumatoid
;
Collagen*
;
Dexamethasone
;
Enzyme-Linked Immunosorbent Assay
;
Immunization
;
Injections, Intradermal
;
Interleukin-10
;
Mice*
;
Necrosis
;
Prevalence
3.Respiratory Difficulty.
Journal of the Korean Medical Association 1998;41(8):861-866
No abstract available.
5.A study on peripheral T cell subsets in patients with thyroid tumors.
Korean Journal of Nuclear Medicine 1991;25(1):110-116
No abstract available.
Humans
;
T-Lymphocyte Subsets*
;
Thyroid Gland*
6.A study on peripheral T cell subsets in patients with thyroid tumors.
Korean Journal of Nuclear Medicine 1991;25(1):110-116
No abstract available.
Humans
;
T-Lymphocyte Subsets*
;
Thyroid Gland*
8.Changes of Interleukin-6 Level in Serum and CSF in Aseptic Meningitis.
Journal of the Korean Pediatric Society 1995;38(5):625-632
No abstract available.
Interleukin-6*
;
Meningitis, Aseptic*
9.A study on the osseointegrated prosthesis using three dimensional finite element method.
The Journal of Korean Academy of Prosthodontics 1991;29(1):167-212
No abstract available.
Prostheses and Implants*
10.Production and characterization of monoclonal antibodies to perchloric acid soluble antigen of M. tuberculosis(TB-II).
Journal of the Korean Pediatric Society 1993;36(8):1116-1123
Mycobacteria cause diseases which occur the world over and which carry a considerable burden in morbidity, mortality and social problems. A battery of monoclonal antibodies specific for mycobacterial antigens would provide a useful tool for rapid diagnosis of mycobacterial diseases. Fourteen monoclonal antibodies to perchloric acid soluble antigen of M. tuberculosis were produced. Immunoglobulin isotypes of monoclonal antibodies were ten of immunoglobulin G2a, two of IgG3, and two of IgM. By means of Western blotting, monoclonal antibody detected the antigen of 54kD in TB-P. In the immunofluorescence assay, the monoclonal antibody showed a positive reaction with intact M. tuberculosis bacilli, M. tuberculosis in the pulmonary tissue of tuberculous patient and M. bovis BCG.
Antibodies, Monoclonal*
;
Blotting, Western
;
Diagnosis
;
Fluorescent Antibody Technique
;
Humans
;
Immunoglobulin G
;
Immunoglobulin Isotypes
;
Immunoglobulin M
;
Immunoglobulins
;
Mortality
;
Mycobacterium bovis
;
Social Problems
;
Tuberculosis