Objective To explore the influencing factors of job satisfaction, social support and dimission intention of nursing staff. Methods Chose 295 cases of medical staff randomly in 2 provincial hospitals in Dalian. Collected data with self-designed questionnaire and analyze influencing factors. Results The influencing factors of job satisfaction included culture level, marriage status, working age, ideal commitment and emotional exhaustion; The influencing factors of social support included culture level, children, individual sense of achievement, standared commitment, economy commitment, society commitment and emotional estrangement;The influencing factors of dimission intention were ideal commitment, night-watch, emotional exhaustion and sentiment estrangement. Conclusions The influencing factors of job satisfaction, social support and dimission intention were defined, we should comprehensively improve physical and mental health of nursing staff aimed at these factors.