2.NOD-like receptor pyrin domain containing 3 inflammasome and myocardial ischemia-reperfusion injury
Bo DONG ; Shenghua ZHOU ; Siyang YU ; Liang TANG
Journal of Central South University(Medical Sciences) 2017;42(7):848-853
Myocardial ischemia-reperfusion injury (MI/RI) is an inflammatory cascade process involving the interaction of multiple factors.In recent years,more and more evidence suggests that NOD-like receptor pyrin domain containing 3 (NLRP3) inflammasome,an important component of the innate immune system,is closely associated with the inflammatory damage of MI/RI.Furthermore,blockage of NLRP3 inflammasome or the release of its downstream pro-inflammatory cytokines may provide new therapeutic targets for this disorder.
3.Research advances and application of molecular genetics in renal pathology.
Liang CHENG ; Xiao-dong TENG ; Shao-bo ZHANG
Chinese Journal of Pathology 2008;37(8):561-565
Adenoma, Oxyphilic
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classification
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pathology
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Carcinoma, Renal Cell
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classification
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metabolism
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pathology
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Humans
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Kidney
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pathology
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Kidney Neoplasms
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classification
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genetics
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pathology
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therapy
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Molecular Biology
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methods
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trends
4.Correlative Study on Acute Ischemic Cerebrovascular Disease and Chlamydia Pneumoniae in Children
jian, CHANG ; dong, LIANG ; dian-bo, CAO ; ji-rong, LU ; yin-bo, CHEN
Journal of Applied Clinical Pediatrics 2003;0(10):-
0.05).Between subgroups divided by the clinical restoration time,the CP IgM seropositive rate of the tachy restoration group was significantly higher than that in the deferred group(P0.05).Among subgroups divided by the clinical manifestation,the subgroup of paralysis plus disorder of consciousness had significant higher CP IgM seropositive rate than other groups(Pa
5.Laparoscopic high ligation of spermatic vein in the treatment of critical varicocele
Shao-Lin ZHANG ; Bo-Chuan CHEN ; Yong-Hua CHEN ; Wei-Dong LIANG ; Liang BAI ; Yu-Xiang ZHONG ;
Chinese Journal of Primary Medicine and Pharmacy 2006;0(12):-
Objective To probe into the clinical curative effect of laparoscopic high ligation of spermatic vein in the treatment of critical varicocele.Methods The clinical data of the 26 eases of laparoscopic high ligation of apermatic vein in the treatment of critical varicocde were reviewed and analyzed in the last two years in this hospi- tal.Results All the 26 cases had been conducted smoothly with the operation time 25~50min,an average of(28?3)min.After 3~24 months being followed-up,all the symptoms and signs disappeared with no relapse and testicle a- trophy.Eight wives of the patients who had been operated on got pregnant.Conclusion With soon recovery and small wound,it was safe to adopt laparoscopic high ligation of spermatic vein in the treatment of critical varicocele, especially for critical two-sided varicocde.
6.A NEW STRAIN OF SPOROCYTOPHAGA
Dong-Bo LIU ; Ying ZHANG ; Shan CHEN ; Xi-Liang LI ; Li-Ping ZHANG ;
Microbiology 1992;0(02):-
A strain of cellulolytic bacterium was isolated from soil by cellulostic plate. The morphological and physiological properties of this strain were studied. According to Bergey's Manual of Determinative Bacteriology ,the strain was identified as a new strain of the Sporocytophaga.
7.Studies on the Fermentation Conditions and Anti-tumor Effect of Exopolysaccharide from Rhizobium sp.N613
Yong HAN ; Xiao-Bo HUANG ; Yue-Feng DONG ; Hong-Bing CHENG ; Liang-Qi ZHAO ;
Microbiology 1992;0(05):-
The potential of Rhizobium sp. N613 to produce the exopolysaccharide (REPS) was studied in this paper. Using an orthogonal design in a flask-shaker culture system, the fermentation medium and conditions of synthesizing REPS were optimized. Based on these results, the fermentation kinetic parameters were obtained in the batch fermentation with a 10L fermentor. The REPS yield of 11.31g/L was achieved by metabolic regulation during 40 h fed-batch fermentation. Transplanted tumor models of sarcoma 180 in mice were used to evaluate the anti-tumor effect. The result of anti-tumor activities showed that inhibition rate was 53.40%, when dose of REPS was 5mg/kg. These results indicate that REPS has the following properties: the short duration of fermentation, the high yield, the low cost, the effective immunocompetence and thickening. Thus, REPS has the value of development and application.
8.Effect of Progesterone on Expressions of Superoxide Dismutase and Matrix Metalloproteinase-3 in Brain Tissues of Neonatal Rats with Hypoxic-Ischemic Brain Damage
shuang, LI ; chun-yang, XU ; hong-bo, JIANG ; dong-liang, LI
Journal of Applied Clinical Pediatrics 2006;0(14):-
Objective To explore the expressions of superoxide dismutase(SOD)and matrix metalloproteinase-3(MMP-3) in the brain tissues of newborn rat after hypoxic-ischemic(HI) and the effects of progesterone(PROG) on SOD and MMP-3 expression.Methods Seventy-two neonatal SD rats were randomly divided into 4 groups:normal control group(normal group),sham-operated group,HI group and PROG group.The model of neonatal rat with hypoxic-ischemic brain damage(HIBD) was made.The permeability of the blood-brain barrier was observed by using transmission electron microscopy,the level of SOD in the brain was assessed by hydroxylammoniumchloride autoxidation,MMP-3 protein expression in cerebral cortex part of the brain was detected by immunohistochemical.SPSS 12.0 software was used to analyze the data.Results In normal group and sham-operated group,capillary vessel′s morphology of blood brain barrier of neonatal rats were integrity and smooth,and structure were clarity.The permeability of blood-brain barrier in HI group was obviously enhanced and had slight changes in PROG group.Compared with the sham-operated group,the level of SOD in HI group significantly decreased(P
9.Usage of fluorine-proof furnace in areas with coal-burning borne endemic fluorosis in Guizhou province in 2009
Ping, HE ; Dong, AN ; Da-sheng, LI ; Bo-you, ZHANG ; Yin, LIANG
Chinese Journal of Endemiology 2011;30(1):60-63
Objective To investigate the usage of fluorine-proof iron stove in regions with coal-burning borne endemic fluorosis of Guizhou province and to provide scientific basis for the project management. Methods According to "the local prevention programs against coal-burning borne endemic fluorosis-Guizhou iron stove usage survey scheme", in the 18 counties implemented the project of improving the iron stove from 2005 to 2008, 2 townships were selected randomly in each county of each project annually, 2 villages were selected in each township randomly, and 10 households were checked in each village. The project households were investigated using questionnaire of the related health knowledge and awareness as well as the satisfaction of the households.Results ①The improvement rate of iron stove was 100.00%(1286/1286). ②The overall utilization rate of the improved stove was 94.09% (1210/1286), in which winter was 62.21% (800/1286) and annual was 31.88%(410/1286). ③Among the households that did not use the project stove, 46.05%(35/76) households was due to switch to other clean energy, in addition, 19.74%(15/76) was due to sell or send to other households, and 14.47%(11/76) was still used to use the open kitchen without the ventilating pipe, and still 13.16%(10/76) was due to high coal prices, and 6.58%(5/76) was due to that the improved stove can not meet the needs of life and no longer used. ④Amoag 1261 households investigated, households with damaged furnace was 24.58%(310/1261 ), and the parts damaged were mainly chimney (ventilating pipe) and the furnace core, accounting for 51.94%(161/310) and 29.03%(90/310), respectively. Repair rate of the damaged parts was 32.58%(101/310). ⑤The health knowledge rate was about 82.74% (1064/1286), and the satisfaction of the iron furnace was 88.65% (1140/1286).Conclusions The improved stoves for the prevention of endemic fluorosis in the diseased area meet the people's living habits, and meet their basic livelihood needs. Most project households are still using the improved furnace.But we still need to further strengthen the project management and the health education intervention, establish and improve stove maintenance network, and reach the goal of sustainable control of coal-burning borne endemic fluorosis.
10.Change of Interleukin-2 in Nasopharyngeal Secretion of Children with Acute Respiratory Syncytial Virus Bronchitis
jian, CHANG ; dong, LIANG ; ji-rong, LU ; yin-bo, CHEN ; hong-xia, ZHAO
Journal of Applied Clinical Pediatrics 1994;0(04):-
0.05).Conclusion There is no association between IL-2 levels in NS and RSV bronchitis.The IL-2 levels show a heterogenous behavior.