Twenty-nail dystrophy is a distinctive pattern of nail changes, in which all 20 nails are uniformly affected with excessive longitudinal ridging and loss of luster. It occurs at any age ranging from children to adulthood, however, it is most commonly diagnosed in children. It can be idiopathic or caused by other inflammatory dermatoses, but the exact cause and pathogenesis of these changes are so far unknown. Several treatment modalities have been employed for treatment of twenty-nail dystrophy, such as topical steroid, intralesional steroids injection, and topical PUVA, however, without much success. We herein report a case of an adults, patient with twenty-nail dystrophy which was successfully treated with topical 0.025% Tretinoin cream.
Adult ; Child ; Humans ; Skin Diseases ; Steroids ; Tretinoin*

Lupus miliaris disseminatus faciei(LMDF) is a erythematous to yellowish asymptomatic papular eruption affecting the cental of the face, which runs a chronic course and terminating spontaneously with scarring. Histopathologically, epithelioid cell granuloma with caseation necrosis is seen in the dermis. Although the disease is self limited, the etiology and pathogenesis are unknown, so there is no effective treatment for LMDF. We report 3 cases of LMDF patients treated with Dapsone with effective results compared to natural history of this disease.
Cicatrix ; Dapsone* ; Dermis ; Epithelioid Cells ; Granuloma ; Humans ; Natural History ; Necrosis

Reconstruction of partial ear defects presents a unique and notable challenge to the dermatologist. This is due to the complex architecture of the external ear which is difficult to duplicate surgically. Several procedures are available for correction of defects to the external ear. However, the diversity of external ear shapes shows how difficult it is to achieve a certain solution to this problem. We report a case of auricular squamous cell carcinoma in which the skin defect is reconstructed by a staged supra-auricular interpolation pedicle flap.
Carcinoma, Squamous Cell ; Ear* ; Ear, External ; Skin

PURPOSE: To report a case of cilioretinal artery occlusion following the intranasal injection of corticosteroids. METHODS: A 52-year-old man was referred to the ophthalmologic clinic due to a marked loss of vision in his right eye immediately after endoscopic sinus surgery. At that time, his vision was noted to be counting fingers in the right eye. His pupil was mid-dilated, fixed, and did not respond to light on examination. On ophthalmoscopy, macula edema with retinal ischemia, and a cherry-red spot were seen in the posterior pole of the retina. Ocular massage was carried out immediately after ophthalmologic examination. Three days later, visual acuity in the right eye improved to 0.15. Fluorescein angiography revealed filling defects of the cilioretinal artery and peripheral branches of the retinal arteries. In addition, areas of nonperfusion were observed. RESULTS: During the follow-up periods, macula edema resolved and visual acuity in the right eye improved to 1.2 after 3 months. Fluorescein angiogram was repeated and showed that the filling defects had disappeared. CONCLUSIONS: Retinal artery occlusion can occur after an intranasal injection of corticosteroids due to embolization of retinal circulation. This condition can be improved without complications by no other specific therapy.
Adrenal Cortex Hormones ; Arteries* ; Edema ; Fingers ; Fluorescein ; Fluorescein Angiography ; Follow-Up Studies ; Humans ; Ischemia ; Massage ; Middle Aged ; Ophthalmoscopy ; Pupil ; Retina ; Retinal Artery ; Retinal Artery Occlusion ; Retinaldehyde ; Visual Acuity

Extramammary Paget's disease is a rare cutaneous neoplasm mostly observed on the genital and perineal areas. In Korea, there has only been one report of extramammary Paget's disease occurring in the axilla. We herein report a case of extramammary Paget's disease of the axilla, confirmed by biopsy and immunohistochemical studies.
Axilla* ; Biopsy ; Korea ; Paget Disease, Extramammary*

ZD1839 (Iressa(R)) is a new anticancer agent, a selective epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that blocks signal transduction pathway implicated in the proliferation and survival of cancer cells and other host-dependent process promoting cancer growth. But this agent can induce cutaneous side effects including acneiform eruption, dry skin, and hair abnormality, which is related with the interruption of normal epidermal and hair follicular kinetics. We report a case of hair change and acneiform eruption induced by ZD1839 (Iressa(R)).
Acneiform Eruptions* ; Hair* ; Kinetics ; Protein-Tyrosine Kinases ; Receptor, Epidermal Growth Factor ; Signal Transduction ; Skin

Since 1970's, Tamoxifen has been used as an antiestrogen agent for adjuvant hormonal therapy, targeting hormone receptor positive breast cancer. Tamoxifen has adverse side effects such as menopausal hot flush, vaginal discharge, irregular menses, thromboembolism, and uterine endometrial carcinoma. Tamoxifen has structure and side effects similar to amphiphilic cationic agents like chlorpromazine, thorazine, amiodarone, and chloroquine. With long period use in high dose, tamoxifen can cause ocular side effects such as retinal crystalline deposition, macular edema, whorl-like corneal opacities, posterior subcapsular lens opacities, optic neuritis, and affected EOG. Recently several reports showed that ocular side effect could happen even in low dose standard treatment. We experienced a case of keratopathy of corneal opacity without disorder of retina, lens, and optic nerve in low dose tamoxifen therapy for breast cancer.
Amiodarone ; Breast Neoplasms* ; Breast* ; Cataract ; Chloroquine ; Chlorpromazine ; Corneal Opacity* ; Crystallins ; Electrooculography ; Endometrial Neoplasms ; Estrogen Receptor Modulators ; Female ; Humans ; Macular Edema ; Optic Nerve ; Optic Neuritis ; Retina ; Retinaldehyde ; Tamoxifen* ; Thromboembolism ; Vaginal Discharge

No abstract available.
Brain* ; Glucose* ; Metabolism* ; Vomiting*

No abstract available.
Brain* ; Epilepsy, Frontal Lobe* ; Frontal Lobe*

BACKGROUND: Urinary tract infection is one of the most common diseases in primary practice. Although quantitative urine culture is the standard for diagnosis, a rapid screening test is needed for effective management. But numerous studies in the past were controversial. We evaluated the utility of dipstick urine analysis as a screening test for urinary tract infection. METHODS: A retrospective analysis of 311 patients who were admitted between May 1997, and April 1998 were chosen as subjects. Patients had a complete urine analysis, such as microscopic analysis, chemical analysis by dipstick and urine culture was performed as part of an evaluation for urinary tract infection or suspicious febrile illness. We compared dipstick analysis with microscopic examination and urine culture. The results of the dipstick urinalysis were compared with the results of the urine culture, sensitivity, specificity, positive predictive value and negative predictive value. RESULTS: A total of 311 cases were included in the study among which 122 cases were true positive in urine culture. For dipstick urine analysis 92 of 122 cases were leukocyte esterase positive and 39 of 122 were nitrite positive. On microscopic examination 44 of 122 cases were leukocyte positive and 40 of 122 were microorganism positive. CONCLUSION: The sensitivity of the dipstick urinalysis seems higher than the microscopic examination in urinary tract infection. We conclude that the dipstick urinalysis is a useful screening test for urinary tract infection for those above 2 years old.
Child, Preschool ; Diagnosis ; Humans ; Leukocytes ; Mass Screening* ; Retrospective Studies ; Sensitivity and Specificity ; Urinalysis* ; Urinary Tract Infections* ; Urinary Tract*