Two cases of malignant melanomas of the choroid were reported. The first case was 43 years old male. The tumor was found to be a mixed type with heavy pigmentation. The second case was 3 years old girl. The tumor cells infiltrated the sclera and the optic nerve with complete destruction of the choroid and extension to the extra-ocular portion was noted without encapsulation. The tumor was composed of spindle A type cells with scanty pigmentation. This second case was interesting due to the reported rare incidence of malignant melanoma in childhood. The statistics in Japan point to the relativelyfrequent occurrence in childhood suggesting the racial differences in the frequency of malignant melanomas in childhood.
Adult ; Child, Preschool ; Choroid* ; Female ; Humans ; Incidence ; Japan ; Male ; Melanoma* ; Optic Nerve ; Pigmentation ; Sclera

Gold fishes were used to determine exophthalmos-inhibitory effect of anti-EPS serum. Anti-EPS Serum was obtained by repeated injection of serum from a patient of malignant exophthalmos to a guinea pig. The exophthalmos-inhibitory effect on fish was determined by measuring the intercorneal distance of fishes by the use of a micrometer before and after the injection of sera, and the percentage in that distance were calculated. The responsiveness of fishes was partly controlled by the injections of normal guinea pig serum and the serum from a patient of endocrine exophthalmos. The injections of the serum from the patient provoked exophthalmos. The injections of the serum from the patient, followed by the injections of normal serum of guinea pig provoked no exophthalmos. The injections of the patient's serum followed by injections of antiserum of guinea pig resulted in marked enophthalmos. These results suggest that the normal guinea pig serum and the antiserum from the guinea pig contains exophthalmos-inhibitory factor, and that this effect was greater in the serum treated by patient's serum.
Animals ; Enophthalmos ; Exophthalmos* ; Fishes ; Guinea Pigs ; Humans

Last year, we had experienced 2 cases of frontal mucocele from which exophthalmos was induced. In both cases, all were male and exophthalmos was unilateral at right eye. They revealed visual disturbances and ocular deviations to the temporal and inferior direction, a]so with the diplopia in one case. The duration of the exophthalmos was 5 months in one case, and 10 years long in another case. They were treated by means of external sinusotomy through the anterior orbitotomy with good results. In one case visual disturbance was also recovered to the normal.
Diplopia ; Exophthalmos* ; Humans ; Male ; Mucocele*