1.Effect of Zoledronic Acid on Acro-Osteolysis and Osteoporosis in a Patient with Hajdu-Cheney Syndrome.
Sena HWANG ; Dong Yoeb SHIN ; Seong Hwan MOON ; Eun Jig LEE ; Sung Kil LIM ; Ok Hwa KIM ; Yumie RHEE
Yonsei Medical Journal 2011;52(3):543-546
Hajdu-Cheney syndrome is a rare, autosomal dominant skeletal dysplasia marked by acro-osteolysis of the distal phalanges and severe osteoporosis. Although there are more than 60 reports published to date, proper treatment and subsequent outcome have been scarce. Herein, we report a progress of anti-resorptive therapy with zoledronic acid, in a woman with Hajdu-Cheney syndrome. Results suggest that anti-resorptive therapy may be important in delaying the progress of osteoporosis and preventing fractures, but not necessarily acro-osteolysis itself.
Acro-Osteolysis/complications/*drug therapy
;
Adult
;
Bone Density Conservation Agents/*therapeutic use
;
Diphosphonates/*therapeutic use
;
Female
;
Hajdu-Cheney Syndrome/complications/*drug therapy
;
Humans
;
Imidazoles/*therapeutic use
;
Osteoporosis/complications/*drug therapy